| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GREAT POINT PARTNERS LLC | 0 | 940,831 | +940,831 | 0.00 | 1.05 | +1.05 | buy |
| STEMPOINT CAPITAL LP | 0 | 845,069 | +845,069 | 0.00 | 1.45 | +1.45 | buy |
| LMR Partners LLP | 0 | 665,529 | +665,529 | 0.00 | 0.08 | +0.08 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,900,000 | 4,400,000 | +500,000 | 0.06 | 0.05 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 413,779 | 900,499 | +486,720 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 135,000 | 608,085 | +473,085 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 353,886 | +353,886 | 0.00 | 0.08 | +0.08 | buy |
| VANGUARD GROUP INC | 1,808,152 | 2,133,613 | +325,461 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 163,492 | +163,492 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 157,963 | +157,963 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 137,490 | +137,490 | 0.00 | 0.14 | +0.14 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 120,454 | +120,454 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 116,658 | +116,658 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 191,171 | 307,487 | +116,316 | 0.00 | 0.00 | +0.00 | buy |
| Troluce Capital Advisors LLC | 0 | 92,832 | +92,832 | 0.00 | 0.11 | +0.11 | buy |
| Aberdeen Group plc | 200,000 | 292,144 | +92,144 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 90,941 | +90,941 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,104 | 112,941 | +90,837 | 0.00 | 0.00 | +0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 0 | 76,024 | +76,024 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 52,478 | 107,665 | +55,187 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 46,867 | +46,867 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 47,000 | 80,000 | +33,000 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 22,940 | +22,940 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 0 | 21,899 | +21,899 | 0.00 | 0.06 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 0 | 20,638 | +20,638 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 76,960 | 97,512 | +20,552 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 20,093 | +20,093 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 19,290 | +19,290 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 223,894 | 241,672 | +17,778 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 31,885 | 47,481 | +15,596 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 15,383 | +15,383 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 13,886 | +13,886 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 13,603 | +13,603 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 30,179 | 43,782 | +13,603 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 13,164 | +13,164 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 12,301 | +12,301 | 0.00 | 0.00 | 0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 12,245 | +12,245 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 11,882 | +11,882 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 488,415 | 499,874 | +11,459 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 0 | 10,199 | +10,199 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 4,224 | +4,224 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 3,937 | +3,937 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,762 | +3,762 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 2,782 | +2,782 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 1,329 | +1,329 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 10,291 | 10,792 | +501 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 2,989,474 | 2,989,474 | 0 | 0.65 | 0.49 | -0.16 | hold |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.28 | 0.21 | -0.07 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 20,700 | 20,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ATLAS CAPITAL ADVISORS INC. | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deer Management Co. LLC | 1,245,504 | 1,245,504 | 0 | 1.79 | 1.50 | -0.29 | hold |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.24 | 0.18 | -0.06 | hold |
| EcoR1 Capital, LLC | 5,000,000 | 5,000,000 | 0 | 1.01 | 0.89 | -0.11 | hold |
| Waldron Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 1,077,080 | 1,077,080 | 0 | 0.34 | 0.32 | -0.02 | hold |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Simplify Asset Management Inc. | 1,046,916 | 1,046,916 | 0 | 0.80 | 0.54 | -0.26 | hold |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.02 | 0.01 | -0.01 | hold |
| DC Funds, LP | 630,000 | 630,000 | 0 | 48.34 | 61.20 | +12.86 | hold |
| Lynx1 Capital Management LP | 5,224,600 | 5,224,600 | 0 | 10.68 | 11.05 | +0.36 | hold |
| Pale Fire Capital SE | 21,573 | 21,573 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Propel Bio Management, LLC | 2,087,139 | 2,087,139 | 0 | 9.65 | 7.92 | -1.73 | hold |
| FEDERATED HERMES, INC. | 56 | 0 | -56 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 1,618 | 0 | -1,618 | 0.00 | 0.00 | -0.00 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 212,200 | 209,830 | -2,370 | 0.03 | 0.02 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 2,551 | 176 | -2,375 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management (UK) Ltd | 15,825 | 12,103 | -3,722 | 0.06 | 0.03 | -0.04 | sell |
| STIFEL FINANCIAL CORP | 101,400 | 95,400 | -6,000 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 10,061 | 0 | -10,061 | 0.00 | 0.00 | -0.00 | sell |
| CTC Alternative Strategies, Ltd. | 11,000 | 0 | -11,000 | 0.05 | 0.00 | -0.05 | sell |
| Jefferies Financial Group Inc. | 12,200 | 0 | -12,200 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 14,200 | 0 | -14,200 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 17,500 | 0 | -17,500 | 0.37 | 0.00 | -0.37 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 19,736 | 0 | -19,736 | 0.04 | 0.00 | -0.04 | sell |
| Y-Intercept (Hong Kong) Ltd | 24,446 | 0 | -24,446 | 0.01 | 0.00 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 63,300 | 38,300 | -25,000 | 0.01 | 0.01 | -0.01 | sell |
| Brevan Howard Capital Management LP | 34,578 | 0 | -34,578 | 0.02 | 0.00 | -0.02 | sell |
| HRT FINANCIAL LP | 34,789 | 0 | -34,789 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 35,661 | 0 | -35,661 | 0.00 | 0.00 | -0.00 | sell |
| Marathon Trading Investment Management LLC | 51,000 | 13,600 | -37,400 | 0.16 | 0.02 | -0.14 | sell |
| TWO SIGMA INVESTMENTS, LP | 37,747 | 0 | -37,747 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 41,942 | 0 | -41,942 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 44,308 | 0 | -44,308 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 153,133 | 99,036 | -54,097 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 77,339 | 18,651 | -58,688 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 143,536 | 78,385 | -65,151 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 67,013 | 0 | -67,013 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 116,921 | 8,446 | -108,475 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 260,148 | 35,268 | -224,880 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 297,902 | 0 | -297,902 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 362,484 | 60,400 | -302,084 | 0.08 | 0.01 | -0.07 | sell |
| MILLENNIUM MANAGEMENT LLC | 392,115 | 27,889 | -364,226 | 0.00 | 0.00 | -0.00 | sell |