| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 5,357,347 | 7,857,347 | +2,500,000 | 2.65 | 3.29 | +0.64 | buy |
| BVF INC/IL | 4,889,474 | 5,226,074 | +336,600 | 0.28 | 0.27 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.04 | 0.04 | -0.00 | hold |
| BlackRock, Inc. | 4,878,833 | 2,566,524 | -2,312,309 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,356,746 | 2,149,376 | -207,370 | 0.00 | 0.00 | -0.00 | sell |
| Propel Bio Management, LLC | 2,087,139 | 2,087,139 | 0 | 3.35 | 3.67 | +0.33 | hold |
| Deer Management Co. LLC | 1,245,504 | 1,245,504 | 0 | 0.16 | 0.14 | -0.02 | hold |
| Alphabet Inc. | 1,077,080 | 1,077,080 | 0 | 0.09 | 0.07 | -0.02 | hold |
| Simplify Asset Management Inc. | 1,046,916 | 1,046,916 | 0 | 0.07 | 0.09 | +0.02 | hold |
| Aberdeen Group plc | 891,448 | 891,448 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MORGAN STANLEY | 0 | 853,346 | +853,346 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 169,706 | 792,056 | +622,350 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 231,175 | 630,138 | +398,963 | 0.00 | 0.00 | +0.00 | buy |
| DC Funds, LP | 630,000 | 630,000 | 0 | 42.07 | 42.43 | +0.37 | hold |
| TANG CAPITAL MANAGEMENT LLC | 600,000 | 600,000 | 0 | 0.05 | 0.04 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,015,090 | 566,371 | -448,719 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 170,349 | 430,070 | +259,721 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 400,401 | +400,401 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 90,201 | 365,034 | +274,833 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 265,101 | 287,743 | +22,642 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 218,987 | +218,987 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 49,000 | 214,400 | +165,400 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 213,396 | +213,396 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 817,248 | 200,513 | -616,735 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 20,840 | 172,512 | +151,672 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 113,300 | 153,700 | +40,400 | 0.00 | 0.01 | +0.00 | buy |
| Troluce Capital Advisors LLC | 83,758 | 150,000 | +66,242 | 0.11 | 0.11 | +0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 143,051 | 143,051 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 270,099 | 129,856 | -140,243 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 116,452 | 115,941 | -511 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 330,024 | 98,548 | -231,476 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 77,100 | 95,875 | +18,775 | 0.00 | 0.00 | +0.00 | buy |
| Militia Capital Partners, LP | 0 | 94,300 | +94,300 | 0.00 | 0.06 | +0.06 | buy |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 76,660 | +76,660 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 68,286 | +68,286 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 55,369 | +55,369 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 53,678 | +53,678 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 37,888 | +37,888 | 0.00 | 0.00 | +0.00 | buy |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.03 | 0.02 | -0.00 | hold |
| HSBC HOLDINGS PLC | 35,042 | 30,501 | -4,541 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 29,070 | +29,070 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 28,030 | +28,030 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 16,242 | 24,363 | +8,121 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 51,841 | 23,697 | -28,144 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 0 | 22,500 | +22,500 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 22,497 | +22,497 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 22,438 | +22,438 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 112,941 | 22,171 | -90,770 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 61,850 | 21,178 | -40,672 | 0.00 | 0.00 | -0.00 | sell |
| Neuberger Berman Group LLC | 0 | 21,167 | +21,167 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 19,892 | +19,892 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 18,000 | +18,000 | 0.00 | 0.01 | +0.01 | buy |
| Mariner, LLC | 14,580 | 17,054 | +2,474 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,878 | +13,878 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,709 | 12,571 | +1,862 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 28,146 | 11,772 | -16,374 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 11,023 | 11,388 | +365 | 0.00 | 0.00 | +0.00 | buy |
| R Squared Ltd | 0 | 11,181 | +11,181 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 21,878 | 10,878 | -11,000 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,847 | 10,507 | +660 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 10,132 | +10,132 | 0.00 | 0.00 | +0.00 | buy |
| Waldron Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 2,182 | 2,181 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,556 | 2,021 | +465 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,218 | 1,218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 352 | 734 | +382 | 0.00 | 0.00 | +0.00 | buy |
| Rialto Wealth Management, LLC | 0 | 381 | +381 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Wealth Partners, Ltd. | 0 | 311 | +311 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 211 | 211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 21 | 70 | +49 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 33 | 42 | +9 | 0.00 | 0.00 | +0.00 | buy |
| ATLAS CAPITAL ADVISORS INC. | 18 | 18 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,762 | 0 | -3,762 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,782 | 0 | -2,782 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 555 | 0 | -555 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 33,683 | 0 | -33,683 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 50,019 | 0 | -50,019 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 10,995 | 0 | -10,995 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,500,000 | 0 | -3,500,000 | 0.01 | 0.00 | -0.01 | sell |
| SG Americas Securities, LLC | 13,581 | 0 | -13,581 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 259 | 0 | -259 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 10,626 | 0 | -10,626 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 41,817 | 0 | -41,817 | 0.01 | 0.00 | -0.01 | sell |
| Bank of New York Mellon Corp | 88,142 | 0 | -88,142 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 582 | 0 | -582 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 662,833 | 0 | -662,833 | 0.05 | 0.00 | -0.05 | sell |
| IFP Advisors, Inc | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,238 | 0 | -23,238 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 69,962 | 0 | -69,962 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 19,031 | 0 | -19,031 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 166 | 0 | -166 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 47,734 | 0 | -47,734 | 0.01 | 0.00 | -0.01 | sell |
| Checkpoint Capital L.P. | 2,017,650 | 0 | -2,017,650 | 1.53 | 0.00 | -1.53 | sell |
| Point72 (DIFC) Ltd | 492 | 0 | -492 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 7,720 | 0 | -7,720 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 3,937 | 0 | -3,937 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,479 | 0 | -15,479 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,169 | 0 | -6,169 | 0.00 | 0.00 | -0.00 | sell |