| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 8,019,148 | 8,019,148 | 0 | 1.28 | 0.91 | -0.37 | hold |
| BVF INC/IL | 5,564,290 | 5,564,290 | 0 | 0.18 | 0.14 | -0.04 | hold |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.02 | 0.01 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,209,009 | 1,949,604 | +740,595 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,364,783 | 1,326,799 | -37,984 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 201,987 | 1,305,840 | +1,103,853 | 0.00 | 0.00 | +0.00 | buy |
| Deer Management Co. LLC | 1,245,504 | 1,245,504 | 0 | 0.20 | 0.15 | -0.05 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,460,285 | 1,163,611 | -296,674 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 808,356 | 1,049,806 | +241,450 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 318,411 | 1,009,107 | +690,696 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,840,952 | 994,654 | -846,298 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 772,241 | +772,241 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 237,346 | 687,364 | +450,018 | 0.00 | 0.00 | +0.00 | buy |
| DC Funds, LP | 630,000 | 630,000 | 0 | 42.40 | 49.27 | +6.87 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 616,952 | 584,811 | -32,141 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 319,587 | 548,402 | +228,815 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 378,960 | 548,087 | +169,127 | 0.02 | 0.03 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 241,493 | +241,493 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 207,313 | 207,313 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIZUHO SECURITIES USA LLC | 0 | 205,600 | +205,600 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 164,601 | +164,601 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 60,720 | 149,467 | +88,747 | 0.00 | 0.00 | +0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 143,051 | 143,051 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 97,448 | 138,778 | +41,330 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 95,875 | 95,875 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 111,900 | 76,900 | -35,000 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 52,635 | 69,487 | +16,852 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 69,400 | 68,200 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 65,335 | 65,335 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kestra Advisory Services, LLC | 62,525 | 62,525 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 27,700 | 36,600 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 25,864 | +25,864 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 24,574 | 24,574 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 17,080 | 19,170 | +2,090 | 0.00 | 0.00 | -0.00 | buy |
| R Squared Ltd | 0 | 18,360 | +18,360 | 0.00 | 0.01 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 21,359 | 17,959 | -3,400 | 0.00 | 0.00 | -0.00 | sell |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 4,295 | 3,982 | -313 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,063 | 2,549 | -2,514 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 713 | 713 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 392 | 392 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Strategic Wealth Partners, Ltd. | 311 | 311 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caitong International Asset Management Co., Ltd | 2 | 1 | -1 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 29,800 | 0 | -29,800 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 18,140 | 0 | -18,140 | 0.00 | 0.00 | -0.00 | sell |
| NINE MASTS CAPITAL Ltd | 41,740 | 0 | -41,740 | 0.01 | 0.00 | -0.01 | sell |
| Aberdeen Group plc | 918,020 | 0 | -918,020 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 28,797 | 0 | -28,797 | 0.00 | 0.00 | -0.00 | sell |