| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 5,224,600 | 5,224,600 | 0 | 11.05 | 9.22 | -1.83 | hold |
| EcoR1 Capital, LLC | 5,000,000 | 5,000,000 | 0 | 0.89 | 0.85 | -0.04 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,400,000 | 4,400,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| BVF INC/IL | 2,989,474 | 2,989,474 | 0 | 0.49 | 0.44 | -0.05 | hold |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.21 | 0.14 | -0.06 | hold |
| VANGUARD GROUP INC | 2,133,613 | 2,346,894 | +213,281 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 2,087,139 | 2,087,139 | 0 | 7.92 | 6.03 | -1.89 | hold |
| Deer Management Co. LLC | 1,245,504 | 1,245,504 | 0 | 1.50 | 0.98 | -0.51 | hold |
| Alphabet Inc. | 1,077,080 | 1,077,080 | 0 | 0.32 | 0.29 | -0.03 | hold |
| Simplify Asset Management Inc. | 1,046,916 | 1,046,916 | 0 | 0.54 | 0.36 | -0.18 | hold |
| GREAT POINT PARTNERS LLC | 940,831 | 1,016,375 | +75,544 | 1.05 | 1.53 | +0.47 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 900,499 | 973,466 | +72,967 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 845,069 | 860,951 | +15,882 | 1.45 | 1.29 | -0.17 | buy |
| Checkpoint Capital L.P. | 0 | 825,341 | +825,341 | 0.00 | 2.04 | +2.04 | buy |
| STATE STREET CORP | 608,085 | 756,499 | +148,414 | 0.00 | 0.00 | -0.00 | buy |
| DC Funds, LP | 630,000 | 630,000 | 0 | 61.20 | 60.91 | -0.29 | hold |
| Aberdeen Group plc | 292,144 | 371,655 | +79,511 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 97,512 | 324,276 | +226,764 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 241,672 | 299,319 | +57,647 | 0.00 | 0.00 | -0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 209,830 | 205,730 | -4,100 | 0.02 | 0.02 | -0.00 | sell |
| MARSHALL WACE, LLP | 307,487 | 165,160 | -142,327 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 35,268 | 158,624 | +123,356 | 0.00 | 0.00 | +0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 76,024 | 143,051 | +67,027 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,882 | 134,297 | +122,415 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 90,941 | 126,345 | +35,404 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 112,941 | 112,941 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 163,492 | 108,584 | -54,908 | 0.01 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 103,440 | +103,440 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 95,400 | 99,133 | +3,733 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 43,782 | 97,211 | +53,429 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 99,036 | 93,876 | -5,160 | 0.00 | 0.00 | +0.00 | sell |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 116,658 | 88,314 | -28,344 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 107,665 | 84,699 | -22,966 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 80,000 | 74,000 | -6,000 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 665,529 | 71,800 | -593,729 | 0.08 | 0.01 | -0.08 | sell |
| BARCLAYS PLC | 13,164 | 58,067 | +44,903 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 55,845 | +55,845 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 78,385 | 54,564 | -23,821 | 0.00 | 0.00 | -0.00 | sell |
| Troluce Capital Advisors LLC | 92,832 | 52,914 | -39,918 | 0.11 | 0.05 | -0.07 | sell |
| MILLENNIUM MANAGEMENT LLC | 27,889 | 48,672 | +20,783 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 46,867 | 47,203 | +336 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 21,573 | 43,723 | +22,150 | 0.01 | 0.03 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 38,300 | 38,300 | 0 | 0.01 | 0.00 | -0.00 | hold |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.18 | 0.12 | -0.05 | hold |
| Cubist Systematic Strategies, LLC | 0 | 32,137 | +32,137 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 31,805 | +31,805 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,446 | 27,793 | +19,347 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,199 | 23,363 | +13,164 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 22,438 | +22,438 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 21,267 | +21,267 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 20,700 | 20,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 20,638 | 20,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 21,899 | 20,620 | -1,279 | 0.06 | 0.06 | -0.00 | sell |
| Corebridge Financial, Inc. | 20,658 | 20,531 | -127 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 499,874 | 18,016 | -481,858 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 15,745 | +15,745 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 15,563 | +15,563 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,383 | 14,798 | -585 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,603 | 13,911 | +308 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,886 | 13,846 | -40 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 12,913 | +12,913 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,301 | 12,301 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OSAIC HOLDINGS, INC. | 12,245 | 12,245 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 22,940 | 10,788 | -12,152 | 0.02 | 0.02 | -0.01 | sell |
| Waldron Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 4,224 | 8,049 | +3,825 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,093 | 6,169 | -13,924 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 0 | 4,477 | +4,477 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,937 | 3,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,762 | 3,762 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalyst Funds Management Pty Ltd | 0 | 3,200 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,782 | 2,782 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,329 | 1,329 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 0 | 1,047 | +1,047 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 425 | +425 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 142 | +142 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 121 | +121 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 176 | 70 | -106 | 0.00 | 0.00 | 0.00 | sell |
| ATLAS CAPITAL ADVISORS INC. | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 0 | 7 | +7 | 0.00 | 0.00 | 0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 2 | +2 | 0.00 | 0.00 | 0.00 | buy |
| Laurion Capital Management LP | 60,400 | 0 | -60,400 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 157,963 | 0 | -157,963 | 0.00 | 0.00 | -0.00 | sell |
| Marathon Trading Investment Management LLC | 13,600 | 0 | -13,600 | 0.02 | 0.00 | -0.02 | sell |
| Alpine Global Management, LLC | 137,490 | 0 | -137,490 | 0.14 | 0.00 | -0.14 | sell |
| Man Group plc | 18,651 | 0 | -18,651 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 19,290 | 0 | -19,290 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 10,792 | 0 | -10,792 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management (UK) Ltd | 12,103 | 0 | -12,103 | 0.03 | 0.00 | -0.03 | sell |
| Paradigm Biocapital Advisors LP | 353,886 | 0 | -353,886 | 0.08 | 0.00 | -0.08 | sell |
| AMERICAN CENTURY COMPANIES INC | 47,481 | 0 | -47,481 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 120,454 | 0 | -120,454 | 0.00 | 0.00 | -0.00 | sell |