| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Checkpoint Capital L.P. | 825,341 | 1,755,987 | +930,646 | 2.04 | 2.72 | +0.68 | buy |
| Aberdeen Group plc | 371,655 | 883,704 | +512,049 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 4,632,876 | 4,961,700 | +328,824 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 134,297 | 280,028 | +145,731 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 142,617 | +142,617 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 5,224,600 | 5,357,347 | +132,747 | 9.22 | 6.11 | -3.11 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 117,847 | +117,847 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 299,319 | 412,858 | +113,539 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 38,300 | 105,900 | +67,600 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 65,139 | +65,139 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 205,730 | 260,870 | +55,140 | 0.02 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 97,211 | 150,114 | +52,903 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 756,499 | 800,948 | +44,449 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 2,346,894 | 2,382,533 | +35,639 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 31,805 | 66,756 | +34,951 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 32,137 | 63,095 | +30,958 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 21,363 | +21,363 | 0.00 | 0.02 | +0.02 | buy |
| Heck Capital Advisors, LLC | 0 | 20,120 | +20,120 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 19,461 | +19,461 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 19,216 | +19,216 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 20,700 | 36,200 | +15,500 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 13,140 | +13,140 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 27,793 | 40,243 | +12,450 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 99,133 | 109,700 | +10,567 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 10,415 | +10,415 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 10,410 | +10,410 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 58,067 | 67,508 | +9,441 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 108,584 | 115,866 | +7,282 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 126,345 | 132,895 | +6,550 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,846 | 19,540 | +5,694 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 15,563 | 20,415 | +4,852 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,301 | 15,479 | +3,178 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 18,016 | 20,628 | +2,612 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 158,624 | 160,673 | +2,049 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,636 | +1,636 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 425 | 1,450 | +1,025 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,267 | 22,214 | +947 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 20,638 | 21,078 | +440 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 68 | 480 | +412 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 105 | +105 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 7 | 16 | +9 | 0.00 | 0.00 | 0.00 | buy |
| IFP Advisors, Inc | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,762 | 3,762 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 2,989,474 | 2,989,474 | 0 | 0.44 | 0.31 | -0.13 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,782 | 2,782 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 70 | 70 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.14 | 0.09 | -0.05 | hold |
| Bank of New York Mellon Corp | 88,314 | 88,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ATLAS CAPITAL ADVISORS INC. | 18 | 18 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BROWN BROTHERS HARRIMAN & CO | 143,051 | 143,051 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deer Management Co. LLC | 1,245,504 | 1,245,504 | 0 | 0.98 | 0.30 | -0.69 | hold |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.12 | 0.07 | -0.05 | hold |
| LMR Partners LLP | 71,800 | 71,800 | 0 | 0.01 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 5,000,000 | 5,000,000 | 0 | 0.85 | 0.61 | -0.25 | hold |
| Waldron Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 1,077,080 | 1,077,080 | 0 | 0.29 | 0.19 | -0.10 | hold |
| OSAIC HOLDINGS, INC. | 12,245 | 12,245 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Briaud Financial Planning, Inc | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Simplify Asset Management Inc. | 1,046,916 | 1,046,916 | 0 | 0.36 | 0.22 | -0.14 | hold |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.01 | 0.00 | -0.00 | hold |
| DC Funds, LP | 630,000 | 630,000 | 0 | 60.91 | 53.75 | -7.16 | hold |
| Troluce Capital Advisors LLC | 52,914 | 52,914 | 0 | 0.05 | 0.02 | -0.03 | hold |
| Pale Fire Capital SE | 43,723 | 43,723 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Propel Bio Management, LLC | 2,087,139 | 2,087,139 | 0 | 6.03 | 6.30 | +0.27 | hold |
| Legal & General Group Plc | 3,937 | 3,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,169 | 6,169 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 112,941 | 112,941 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,329 | 1,329 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 2 | 0 | -2 | 0.00 | 0.00 | 0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 121 | 60 | -61 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,798 | 14,715 | -83 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 142 | 0 | -142 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 47,203 | 46,807 | -396 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 1,047 | 0 | -1,047 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,911 | 12,786 | -1,125 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 20,531 | 19,090 | -1,441 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 8,049 | 6,160 | -1,889 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 324,276 | 322,096 | -2,180 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 4,477 | 2,265 | -2,212 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 3,200 | 0 | -3,200 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 973,466 | 963,257 | -10,209 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 10,788 | 0 | -10,788 | 0.02 | 0.00 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 12,913 | 0 | -12,913 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 15,745 | 0 | -15,745 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 20,620 | 0 | -20,620 | 0.06 | 0.00 | -0.06 | sell |
| XTX Topco Ltd | 22,438 | 0 | -22,438 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 23,363 | 0 | -23,363 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 54,564 | 14,508 | -40,056 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 48,672 | 0 | -48,672 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 55,845 | 0 | -55,845 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 74,000 | 10,600 | -63,400 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 103,440 | 18,951 | -84,489 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 84,699 | 0 | -84,699 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 93,876 | 0 | -93,876 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 165,160 | 43,969 | -121,191 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 860,951 | 0 | -860,951 | 1.29 | 0.00 | -1.29 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,400,000 | 3,500,000 | -900,000 | 0.04 | 0.02 | -0.02 | sell |
| GREAT POINT PARTNERS LLC | 1,016,375 | 0 | -1,016,375 | 1.53 | 0.00 | -1.53 | sell |