| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 7,857,347 | 8,019,148 | +161,801 | 2.91 | 1.62 | -1.29 | buy |
| BVF INC/IL | 5,226,074 | 5,226,074 | 0 | 0.39 | 0.18 | -0.21 | hold |
| BAKER BROS. ADVISORS LP | 2,784,792 | 2,784,792 | 0 | 0.04 | 0.02 | -0.02 | hold |
| VANGUARD GROUP INC | 2,317,916 | 2,475,733 | +157,817 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 2,382,764 | 1,848,695 | -534,069 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 1,354,820 | 1,785,241 | +430,421 | 0.00 | 0.00 | -0.00 | buy |
| Deer Management Co. LLC | 1,245,504 | 1,245,504 | 0 | 0.20 | 0.12 | -0.08 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 829,919 | 1,141,069 | +311,150 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 419,404 | 651,179 | +231,775 | 0.00 | 0.00 | -0.00 | buy |
| DC Funds, LP | 630,000 | 630,000 | 0 | 36.87 | 43.36 | +6.49 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 567,657 | 562,153 | -5,504 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 466,086 | 403,618 | -62,468 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 388,284 | +388,284 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 288,800 | 353,900 | +65,100 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 46,630 | 339,240 | +292,610 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 226,164 | +226,164 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 17,626 | 219,001 | +201,375 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 197,313 | 207,313 | +10,000 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 188,152 | +188,152 | 0.00 | 0.00 | +0.00 | buy |
| BROWN BROTHERS HARRIMAN & CO | 143,051 | 143,051 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 140,400 | 115,400 | -25,000 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 98,548 | 98,198 | -350 | 0.00 | 0.00 | -0.00 | sell |
| LETKO, BROSSEAU & ASSOCIATES INC | 95,875 | 95,875 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Wealth, LLC | 91,463 | 91,463 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 87,316 | 74,467 | -12,849 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 97,400 | 72,400 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 69,427 | +69,427 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 600,000 | 46,131 | -553,869 | 0.04 | 0.00 | -0.04 | sell |
| DC Investments Management, LLC | 35,563 | 35,563 | 0 | 0.03 | 0.02 | -0.01 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 29,538 | +29,538 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 26,581 | +26,581 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 29,870 | 26,360 | -3,510 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 25,256 | +25,256 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 24,574 | 24,574 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 11,500 | 24,400 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 19,077 | 23,196 | +4,119 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 18,400 | 18,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| R Squared Ltd | 18,827 | 16,033 | -2,794 | 0.01 | 0.01 | -0.01 | sell |
| TWO SIGMA SECURITIES, LLC | 0 | 15,942 | +15,942 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 20,992 | 14,677 | -6,315 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 14,512 | +14,512 | 0.00 | 0.00 | +0.00 | buy |
| Waldron Private Wealth LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aries Wealth Management | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIZUHO SECURITIES USA LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 11,115 | 6,766 | -4,349 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 2,181 | 4,989 | +2,808 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 212 | 392 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Wealth Partners, Ltd. | 311 | 311 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 28,030 | 0 | -28,030 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 16,031 | 0 | -16,031 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 390,747 | 0 | -390,747 | 0.00 | 0.00 | -0.00 | sell |
| ATLAS CAPITAL ADVISORS INC. | 18 | 0 | -18 | 0.00 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 47,879 | 0 | -47,879 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 60,480 | 0 | -60,480 | 0.01 | 0.00 | -0.01 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,029 | 0 | -2,029 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 56,666 | 0 | -56,666 | 0.00 | 0.00 | -0.00 | sell |
| Alphabet Inc. | 1,077,080 | 0 | -1,077,080 | 0.08 | 0.00 | -0.08 | sell |
| EverSource Wealth Advisors, LLC | 65 | 0 | -65 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 27,675 | 0 | -27,675 | 0.00 | 0.00 | -0.00 | sell |
| Militia Capital Partners, LP | 102,100 | 0 | -102,100 | 0.09 | 0.00 | -0.09 | sell |
| Simplify Asset Management Inc. | 904,972 | 0 | -904,972 | 0.03 | 0.00 | -0.03 | sell |
| Catalyst Funds Management Pty Ltd | 30,763 | 0 | -30,763 | 0.01 | 0.00 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 9,197 | 0 | -9,197 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 237,750 | 0 | -237,750 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 9 | 0 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Propel Bio Management, LLC | 1,932,304 | 0 | -1,932,304 | 3.52 | 0.00 | -3.52 | sell |
| Rialto Wealth Management, LLC | 381 | 0 | -381 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,020 | 0 | -1,020 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 9,993 | 0 | -9,993 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 1,088 | 0 | -1,088 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 130,980 | 0 | -130,980 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 847,537 | 0 | -847,537 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 593 | 0 | -593 | 0.00 | 0.00 | -0.00 | sell |