| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,744,415 | +1,744,415 | 0.00 | 0.23 | +0.23 | buy |
| Novo Holdings A/S | 0 | 1,739,175 | +1,739,175 | 0.00 | 1.27 | +1.27 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,343,201 | +1,343,201 | 0.00 | 0.08 | +0.08 | buy |
| PFM Health Sciences, LP | 0 | 1,267,002 | +1,267,002 | 0.00 | 0.66 | +0.66 | buy |
| HHLR ADVISORS, LTD. | 0 | 777,768 | +777,768 | 0.00 | 0.18 | +0.18 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 747,548 | +747,548 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 723,901 | +723,901 | 0.00 | 0.01 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 583,041 | +583,041 | 0.00 | 0.10 | +0.10 | buy |
| Sozo Ventures GP II, L.P. | 0 | 581,577 | +581,577 | 0.00 | 2.09 | +2.09 | buy |
| Deep Track Capital, LP | 0 | 466,232 | +466,232 | 0.00 | 0.14 | +0.14 | buy |
| PURA VIDA INVESTMENTS, LLC | 0 | 461,283 | +461,283 | 0.00 | 3.31 | +3.31 | buy |
| Point72 Asset Management, L.P. | 0 | 371,100 | +371,100 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 350,859 | +350,859 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 0 | 300,000 | +300,000 | 0.00 | 0.08 | +0.08 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 279,025 | +279,025 | 0.00 | 0.12 | +0.12 | buy |
| ExodusPoint Capital Management, LP | 0 | 227,556 | +227,556 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 183,027 | +183,027 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 179,547 | +179,547 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 125,000 | +125,000 | 0.00 | 0.15 | +0.15 | buy |
| NORGES BANK | 0 | 107,892 | +107,892 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 86,763 | +86,763 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 66,666 | +66,666 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 52,058 | +52,058 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 31,477 | +31,477 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 30,148 | +30,148 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 26,488 | +26,488 | 0.00 | 0.00 | +0.00 | buy |
| Bramshill Investments, LLC | 0 | 25,500 | +25,500 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 24,894 | +24,894 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 22,009 | +22,009 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 20,159 | +20,159 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 0 | 16,668 | +16,668 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 16,667 | +16,667 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 13,747 | +13,747 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 13,053 | +13,053 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Advisors LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 4,500 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 952 | +952 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 456 | +456 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 355 | +355 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |