| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORGES BANK | 107,892 | 360,202 | +252,310 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 86,763 | 164,235 | +77,472 | 0.00 | 0.00 | -0.00 | buy |
| Novo Holdings A/S | 1,739,175 | 1,800,000 | +60,825 | 1.27 | 0.40 | -0.87 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 44,156 | +44,156 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 179,547 | 216,166 | +36,619 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 0 | 30,474 | +30,474 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 26,600 | +26,600 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 20,159 | 37,694 | +17,535 | 0.00 | 0.00 | -0.00 | buy |
| Resolute Advisors LLC | 10,000 | 26,500 | +16,500 | 0.02 | 0.03 | +0.01 | buy |
| XTX Topco Ltd | 0 | 16,244 | +16,244 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,148 | 45,111 | +14,963 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 6,423 | +6,423 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 723,901 | 729,852 | +5,951 | 0.01 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 5,543 | +5,543 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 5,440 | +5,440 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 456 | 4,375 | +3,919 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 2,295 | +2,295 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 2,166 | +2,166 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 24,894 | 26,312 | +1,418 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 618 | +618 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 13,053 | 13,596 | +543 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 457 | +457 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 218 | +218 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 300,000 | 300,000 | 0 | 0.08 | 0.03 | -0.05 | hold |
| PRINCIPAL SECURITIES, INC. | 54 | 54 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFM Health Sciences, LP | 1,267,002 | 1,267,002 | 0 | 0.66 | 0.28 | -0.38 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 583,041 | 583,041 | 0 | 0.10 | 0.04 | -0.06 | hold |
| Larson Financial Group LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HHLR ADVISORS, LTD. | 777,768 | 777,768 | 0 | 0.18 | 0.08 | -0.10 | hold |
| Deep Track Capital, LP | 466,232 | 466,232 | 0 | 0.14 | 0.06 | -0.08 | hold |
| Sozo Ventures GP II, L.P. | 581,577 | 581,577 | 0 | 2.09 | 0.97 | -1.11 | hold |
| US BANCORP \DE\ | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 1,343,201 | 1,343,201 | 0 | 0.08 | 0.03 | -0.05 | hold |
| MACQUARIE GROUP LTD | 355 | 0 | -355 | 0.00 | 0.00 | -0.00 | sell |
| ASSETMARK, INC | 952 | 0 | -952 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 10,000 | 491 | -9,509 | 0.00 | 0.00 | -0.00 | sell |
| Bramshill Investments, LLC | 25,500 | 15,500 | -10,000 | 0.03 | 0.01 | -0.02 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 13,747 | 0 | -13,747 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 183,027 | 168,639 | -14,388 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 16,668 | 1,390 | -15,278 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 16,667 | 1,053 | -15,614 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 26,488 | 10,202 | -16,286 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 20,000 | 0 | -20,000 | 0.01 | 0.00 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 22,009 | 0 | -22,009 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 31,477 | 0 | -31,477 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 279,025 | 245,692 | -33,333 | 0.12 | 0.05 | -0.08 | sell |
| ExodusPoint Capital Management, LP | 227,556 | 192,763 | -34,793 | 0.03 | 0.01 | -0.02 | sell |
| Hudson Bay Capital Management LP | 66,666 | 17,000 | -49,666 | 0.01 | 0.00 | -0.01 | sell |
| LMR Partners LLP | 52,058 | 0 | -52,058 | 0.01 | 0.00 | -0.01 | sell |
| Ghisallo Capital Management LLC | 125,000 | 0 | -125,000 | 0.15 | 0.00 | -0.15 | sell |
| PURA VIDA INVESTMENTS, LLC | 461,283 | 270,618 | -190,665 | 3.31 | 1.26 | -2.06 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,744,415 | 1,477,749 | -266,666 | 0.23 | 0.08 | -0.15 | sell |
| Point72 Asset Management, L.P. | 371,100 | 99,002 | -272,098 | 0.01 | 0.00 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 350,859 | 0 | -350,859 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 747,548 | 313,162 | -434,386 | 0.01 | 0.00 | -0.01 | sell |