| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Novo Holdings A/S | 1,800,000 | 1,800,000 | 0 | 0.40 | 0.19 | -0.20 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,477,749 | 1,305,239 | -172,510 | 0.08 | 0.03 | -0.05 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 1,343,201 | 1,057,201 | -286,000 | 0.03 | 0.01 | -0.02 | sell |
| PFM Health Sciences, LP | 1,267,002 | 1,034,002 | -233,000 | 0.28 | 0.13 | -0.15 | sell |
| CITADEL ADVISORS LLC | 729,852 | 804,462 | +74,610 | 0.00 | 0.00 | -0.00 | buy |
| HHLR ADVISORS, LTD. | 777,768 | 777,768 | 0 | 0.08 | 0.04 | -0.04 | hold |
| Sozo Ventures GP II, L.P. | 581,577 | 581,577 | 0 | 0.97 | 0.65 | -0.33 | hold |
| MILLENNIUM MANAGEMENT LLC | 313,162 | 417,878 | +104,716 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 216,166 | 373,903 | +157,737 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 360,202 | 360,202 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 164,235 | 338,031 | +173,796 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 466,232 | 307,500 | -158,732 | 0.06 | 0.02 | -0.04 | sell |
| ExodusPoint Capital Management, LP | 192,763 | 280,287 | +87,524 | 0.01 | 0.01 | -0.00 | buy |
| PURA VIDA INVESTMENTS, LLC | 270,618 | 270,618 | 0 | 1.26 | 0.97 | -0.29 | hold |
| Kestra Advisory Services, LLC | 0 | 230,305 | +230,305 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 182,100 | +182,100 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 168,639 | 168,639 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 44,156 | 136,624 | +92,468 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 92,200 | +92,200 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 37,694 | 85,606 | +47,912 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 13,596 | 78,398 | +64,802 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,312 | 61,606 | +35,294 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 37,675 | +37,675 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 0 | 31,693 | +31,693 | 0.00 | 0.05 | +0.05 | buy |
| STATE STREET CORP | 30,474 | 30,744 | +270 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 30,300 | +30,300 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Advisors LLC | 26,500 | 26,500 | 0 | 0.03 | 0.01 | -0.02 | hold |
| BROWN ADVISORY INC | 0 | 25,006 | +25,006 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 21,800 | +21,800 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 0 | 20,648 | +20,648 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 19,629 | +19,629 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 15,263 | +15,263 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,111 | 14,779 | -30,332 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 14,074 | +14,074 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,600 | 13,900 | -12,700 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 5,543 | 12,799 | +7,256 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 12,441 | +12,441 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 10,202 | 11,526 | +1,324 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 2,166 | 8,698 | +6,532 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 7,415 | +7,415 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 6,423 | 5,372 | -1,051 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,375 | 5,247 | +872 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,390 | 4,568 | +3,178 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 4,519 | +4,519 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 5,440 | 3,695 | -1,745 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 3,463 | +3,463 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 3,395 | 3,374 | -21 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 3,237 | +3,237 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 54 | 687 | +633 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 618 | 618 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 491 | 491 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 457 | 457 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 218 | 218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 (DIFC) Ltd | 2,295 | 97 | -2,198 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 0 | 88 | +88 | 0.00 | 0.00 | 0.00 | buy |
| Larson Financial Group LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 300,000 | 0 | -300,000 | 0.03 | 0.00 | -0.03 | sell |
| Hudson Bay Capital Management LP | 17,000 | 0 | -17,000 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 583,041 | 0 | -583,041 | 0.04 | 0.00 | -0.04 | sell |
| Cerity Partners LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 99,002 | 0 | -99,002 | 0.00 | 0.00 | -0.00 | sell |
| Bramshill Investments, LLC | 15,500 | 0 | -15,500 | 0.01 | 0.00 | -0.01 | sell |
| Qube Research & Technologies Ltd | 1,053 | 0 | -1,053 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 16,244 | 0 | -16,244 | 0.01 | 0.00 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 245,692 | 0 | -245,692 | 0.05 | 0.00 | -0.05 | sell |