| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 1,688,054 | +1,688,054 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 890,000 | +890,000 | 0.00 | 0.68 | +0.68 | buy |
| Eagle Health Investments LP | 0 | 700,000 | +700,000 | 0.00 | 0.86 | +0.86 | buy |
| Verition Fund Management LLC | 0 | 571,466 | +571,466 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 873,438 | 1,107,347 | +233,909 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 175,798 | +175,798 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 172,794 | +172,794 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 157,226 | +157,226 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 79,213 | 201,236 | +122,023 | 0.01 | 0.04 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 444,359 | 565,417 | +121,058 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 2,384 | 117,013 | +114,629 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 78,671 | 172,883 | +94,212 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 79,639 | +79,639 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 71,556 | +71,556 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 71,184 | +71,184 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 177,300 | 247,600 | +70,300 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 194,308 | 259,680 | +65,372 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 62,923 | 111,625 | +48,702 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 40,649 | +40,649 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 146,736 | 185,059 | +38,323 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 37,628 | +37,628 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 37,321 | +37,321 | 0.00 | 0.00 | +0.00 | buy |
| DENALI ADVISORS LLC | 0 | 26,600 | +26,600 | 0.00 | 0.05 | +0.05 | buy |
| MARSHALL WACE, LLP | 0 | 26,284 | +26,284 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 25,240 | +25,240 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 24,978 | +24,978 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 24,594 | +24,594 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 23,264 | +23,264 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 23,048 | +23,048 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 18,910 | +18,910 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,154 | +14,154 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 10,537 | +10,537 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1,878 | +1,878 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 940 | +940 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,086 | 85,086 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 4,284,172 | 4,284,172 | 0 | 8.13 | 11.32 | +3.20 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,144,881 | 6,144,881 | 0 | 0.37 | 0.51 | +0.14 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | 626,810 | 0 | 0.45 | 0.66 | +0.21 | hold |
| MPM BioImpact LLC | 2,388,011 | 2,388,011 | 0 | 2.16 | 2.49 | +0.33 | hold |
| CERTUITY, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| DC Funds, LP | 589,102 | 589,102 | 0 | 27.34 | 36.89 | +9.55 | hold |
| Financial Perspectives, Inc | 6,750 | 6,750 | 0 | 0.01 | 0.02 | +0.01 | hold |
| EDGEWOOD MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 49,648 | 48,502 | -1,146 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 5,698 | 202 | -5,496 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 83,468 | 71,168 | -12,300 | 0.00 | 0.00 | +0.00 | sell |
| HBK Sorce Advisory LLC | 26,454 | 13,227 | -13,227 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 15,400 | 0 | -15,400 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 20,383 | 0 | -20,383 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 21,522 | 0 | -21,522 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 22,472 | 0 | -22,472 | 0.01 | 0.00 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 107,506 | 84,200 | -23,306 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,034,255 | 3,000,594 | -33,661 | 0.02 | 0.04 | +0.01 | sell |
| Alyeska Investment Group, L.P. | 435,705 | 235,705 | -200,000 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 2,096,081 | 1,881,113 | -214,968 | 0.00 | 0.00 | +0.00 | sell |
| Rubric Capital Management LP | 1,935,357 | 1,621,034 | -314,323 | 0.28 | 0.31 | +0.03 | sell |
| PFM Health Sciences, LP | 3,468,177 | 3,006,734 | -461,443 | 0.80 | 0.97 | +0.17 | sell |