| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 596,289 | 784,617 | +188,328 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,420,969 | 1,509,436 | +88,467 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 81,669 | +81,669 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| MPM ASSET MANAGEMENT LLC | 4,284,172 | 4,309,860 | +25,688 | 5.10 | 6.03 | +0.94 | buy |
| BANK OF AMERICA CORP /DE/ | 2,078,875 | 2,103,142 | +24,267 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 71,860 | 95,712 | +23,852 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 2,388,011 | 2,408,810 | +20,799 | 0.50 | 0.40 | -0.10 | buy |
| STATE STREET CORP | 426,772 | 444,272 | +17,500 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 702,558 | 717,524 | +14,966 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 244,390 | 258,458 | +14,068 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 11,828 | +11,828 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 10,837 | +10,837 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 242,264 | 250,676 | +8,412 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,866 | 22,239 | +7,373 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 56,900 | 63,900 | +7,000 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 6,785 | +6,785 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 414 | 6,130 | +5,716 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,856 | 9,142 | +3,286 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,831 | 4,461 | +2,630 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 28,916 | 31,231 | +2,315 | 0.00 | 0.00 | -0.00 | buy |
| Rossby Financial, LCC | 0 | 860 | +860 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,871 | 18,651 | +780 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 1,634 | 1,890 | +256 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 15,156 | 15,355 | +199 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 33 | 35 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,987 | 2,987 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,209 | 2,209 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,144,881 | 6,144,881 | 0 | 0.12 | 0.10 | -0.02 | hold |
| Alyeska Investment Group, L.P. | 235,705 | 235,705 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | 626,810 | 0 | 0.17 | 0.15 | -0.02 | hold |
| Regal Investment Advisors LLC | 27,204 | 27,204 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rubric Capital Management LP | 1,333,893 | 1,333,893 | 0 | 0.04 | 0.02 | -0.01 | hold |
| Larson Financial Group LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CERTUITY, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TFC Financial Management, Inc. | 2,500 | 2,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DC Funds, LP | 589,102 | 589,102 | 0 | 24.47 | 27.71 | +3.24 | hold |
| Financial Perspectives, Inc | 6,750 | 6,750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 21,322 | 21,322 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 2,642 | 2,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,100 | 5,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EDGEWOOD MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,055 | 1,055 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 101,626 | 101,626 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 771 | 414 | -357 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 14,589 | 14,232 | -357 | 0.00 | 0.00 | -0.00 | sell |
| HBK Sorce Advisory LLC | 15,357 | 13,541 | -1,816 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 23,729 | 21,907 | -1,822 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,832 | 3,365 | -3,467 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 71,300 | 62,407 | -8,893 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 12,740 | 0 | -12,740 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 13,779 | 0 | -13,779 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 59,748 | 45,361 | -14,387 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 17,776 | 0 | -17,776 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 24,905 | 0 | -24,905 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 1,700,432 | 1,671,855 | -28,577 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 141,830 | 111,985 | -29,845 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 93,440 | 58,132 | -35,308 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 96,850 | 59,347 | -37,503 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 42,511 | 0 | -42,511 | 0.00 | 0.00 | -0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 50,000 | 0 | -50,000 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 139,100 | 77,000 | -62,100 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 62,928 | 0 | -62,928 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 109,586 | 39,586 | -70,000 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 194,746 | 84,607 | -110,139 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 241,056 | 0 | -241,056 | 0.03 | 0.00 | -0.03 | sell |
| PFM Health Sciences, LP | 2,905,465 | 2,506,520 | -398,945 | 0.33 | 0.19 | -0.14 | sell |