| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 565,417 | 1,110,298 | +544,881 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 259,680 | 645,297 | +385,617 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 71,168 | 423,911 | +352,743 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 319,477 | +319,477 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,881,113 | 2,147,425 | +266,312 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 3,006,734 | 3,241,074 | +234,340 | 0.97 | 0.43 | -0.54 | buy |
| BIT Capital GmbH | 0 | 233,370 | +233,370 | 0.00 | 0.05 | +0.05 | buy |
| VANGUARD GROUP INC | 1,107,347 | 1,323,781 | +216,434 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 37,628 | 197,377 | +159,749 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 26,284 | 134,184 | +107,900 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 98,440 | +98,440 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 37,321 | 125,484 | +88,163 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 84,200 | 171,000 | +86,800 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 78,842 | +78,842 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 67,644 | +67,644 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 63,954 | +63,954 | 0.00 | 0.00 | +0.00 | buy |
| Murchinson Ltd. | 0 | 62,500 | +62,500 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 111,625 | 160,577 | +48,952 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,086 | 125,086 | +40,000 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 39,900 | +39,900 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 172,883 | 212,296 | +39,413 | 0.00 | 0.00 | -0.00 | buy |
| Alpine Global Management, LLC | 0 | 37,551 | +37,551 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 37,500 | +37,500 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 185,059 | 219,366 | +34,307 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 32,547 | +32,547 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,878 | 23,820 | +21,942 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 21,099 | +21,099 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 14,046 | +14,046 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 14,028 | +14,028 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 10,537 | 23,767 | +13,230 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 24,978 | 37,634 | +12,656 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 48,502 | 58,598 | +10,096 | 0.00 | 0.00 | -0.00 | buy |
| Paloma Partners Management Co | 0 | 10,043 | +10,043 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,987 | +2,987 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,642 | +2,642 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 2,209 | +2,209 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 1,055 | +1,055 | 0.00 | 0.00 | +0.00 | buy |
| MPM ASSET MANAGEMENT LLC | 4,284,172 | 4,284,172 | 0 | 11.32 | 5.74 | -5.58 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,144,881 | 6,144,881 | 0 | 0.51 | 0.20 | -0.31 | hold |
| HBK Sorce Advisory LLC | 13,227 | 13,227 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 235,705 | 235,705 | 0 | 0.01 | 0.00 | -0.01 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | 626,810 | 0 | 0.66 | 0.25 | -0.41 | hold |
| MPM BioImpact LLC | 2,388,011 | 2,388,011 | 0 | 2.49 | 0.91 | -1.58 | hold |
| CERTUITY, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Eagle Health Investments LP | 700,000 | 700,000 | 0 | 0.86 | 0.31 | -0.56 | hold |
| DC Funds, LP | 589,102 | 589,102 | 0 | 36.89 | 23.87 | -13.02 | hold |
| Financial Perspectives, Inc | 6,750 | 6,750 | 0 | 0.02 | 0.01 | -0.01 | hold |
| EDGEWOOD MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 202 | 136 | -66 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 940 | 0 | -940 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 247,600 | 239,300 | -8,300 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 10,800 | 0 | -10,800 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 40,649 | 28,371 | -12,278 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 23,048 | 10,459 | -12,589 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 14,154 | 0 | -14,154 | 0.01 | 0.00 | -0.01 | sell |
| Brevan Howard Capital Management LP | 18,910 | 0 | -18,910 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 23,264 | 0 | -23,264 | 0.04 | 0.00 | -0.04 | sell |
| Squarepoint Ops LLC | 24,594 | 0 | -24,594 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 25,240 | 0 | -25,240 | 0.00 | 0.00 | -0.00 | sell |
| DENALI ADVISORS LLC | 26,600 | 0 | -26,600 | 0.05 | 0.00 | -0.05 | sell |
| Man Group plc | 79,639 | 44,481 | -35,158 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 71,556 | 6,791 | -64,765 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 71,184 | 0 | -71,184 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 117,013 | 8,315 | -108,698 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 172,794 | 52,089 | -120,705 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 157,226 | 0 | -157,226 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 175,798 | 0 | -175,798 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 201,236 | 0 | -201,236 | 0.04 | 0.00 | -0.04 | sell |
| Rubric Capital Management LP | 1,621,034 | 1,333,893 | -287,141 | 0.31 | 0.09 | -0.22 | sell |
| Verition Fund Management LLC | 571,466 | 233,828 | -337,638 | 0.04 | 0.00 | -0.03 | sell |
| Monashee Investment Management LLC | 890,000 | 0 | -890,000 | 0.68 | 0.00 | -0.68 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,000,594 | 2,000,594 | -1,000,000 | 0.04 | 0.01 | -0.03 | sell |
| JANUS HENDERSON GROUP PLC | 1,688,054 | 167,987 | -1,520,067 | 0.01 | 0.00 | -0.01 | sell |