| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 1,110,298 | 1,323,773 | +213,475 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 58,598 | 227,750 | +169,152 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 3,241,074 | 3,398,747 | +157,673 | 0.43 | 0.41 | -0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 160,577 | 257,844 | +97,267 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,323,781 | 1,415,530 | +91,749 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 52,089 | 115,141 | +63,052 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 212,296 | 265,359 | +53,063 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 423,911 | 476,439 | +52,528 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 645,297 | 685,989 | +40,692 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 23,820 | 54,810 | +30,990 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 21,322 | +21,322 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 21,209 | +21,209 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 18,454 | +18,454 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 17,111 | +17,111 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 239,300 | 256,300 | +17,000 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 6,791 | 23,011 | +16,220 | 0.00 | 0.00 | +0.00 | buy |
| Regal Investment Advisors LLC | 0 | 14,459 | +14,459 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,517 | +13,517 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 11,777 | +11,777 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 98,440 | 108,968 | +10,528 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 233,370 | 241,056 | +7,686 | 0.05 | 0.05 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,147,425 | 2,153,717 | +6,292 | 0.00 | 0.00 | -0.00 | buy |
| CERTUITY, LLC | 10,000 | 15,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 37,634 | 41,413 | +3,779 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 136 | 3,439 | +3,303 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 1,514 | +1,514 | 0.00 | 0.00 | +0.00 | buy |
| HBK Sorce Advisory LLC | 13,227 | 13,679 | +452 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 192 | +192 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,987 | 2,987 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,209 | 2,209 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,594 | 2,000,594 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 4,284,172 | 4,284,172 | 0 | 5.74 | 6.25 | +0.51 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,144,881 | 6,144,881 | 0 | 0.20 | 0.15 | -0.05 | hold |
| Alyeska Investment Group, L.P. | 235,705 | 235,705 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | 626,810 | 0 | 0.25 | 0.22 | -0.03 | hold |
| MPM BioImpact LLC | 2,388,011 | 2,388,011 | 0 | 0.91 | 0.76 | -0.15 | hold |
| Rubric Capital Management LP | 1,333,893 | 1,333,893 | 0 | 0.09 | 0.05 | -0.04 | hold |
| TFC Financial Management, Inc. | 1,500 | 1,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Eagle Health Investments LP | 700,000 | 700,000 | 0 | 0.31 | 0.29 | -0.02 | hold |
| DC Funds, LP | 589,102 | 589,102 | 0 | 23.87 | 24.25 | +0.38 | hold |
| Financial Perspectives, Inc | 6,750 | 6,750 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 2,642 | 2,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EDGEWOOD MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 78,842 | 78,842 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,055 | 1,055 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corebridge Financial, Inc. | 16,401 | 16,300 | -101 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 14,028 | 13,636 | -392 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 32,547 | 28,396 | -4,151 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 8,315 | 0 | -8,315 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 67,644 | 57,928 | -9,716 | 0.00 | 0.00 | -0.00 | sell |
| Paloma Partners Management Co | 10,043 | 0 | -10,043 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 10,459 | 0 | -10,459 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 14,046 | 381 | -13,665 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 23,767 | 5,256 | -18,511 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 171,000 | 152,200 | -18,800 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 21,099 | 0 | -21,099 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 28,371 | 0 | -28,371 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,900 | 5,100 | -34,800 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 125,086 | 88,086 | -37,000 | 0.01 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 37,500 | 0 | -37,500 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 37,551 | 0 | -37,551 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 219,366 | 180,608 | -38,758 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 44,481 | 0 | -44,481 | 0.00 | 0.00 | -0.00 | sell |
| Murchinson Ltd. | 62,500 | 0 | -62,500 | 0.03 | 0.00 | -0.03 | sell |
| CITADEL ADVISORS LLC | 63,954 | 0 | -63,954 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 125,484 | 0 | -125,484 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 134,184 | 0 | -134,184 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 167,987 | 0 | -167,987 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 197,377 | 0 | -197,377 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 319,477 | 109,816 | -209,661 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 233,828 | 0 | -233,828 | 0.00 | 0.00 | -0.00 | sell |