| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 0 | 154,534 | +154,534 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 316,300 | 456,000 | +139,700 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,298,251 | 1,408,047 | +109,796 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 46,711 | +46,711 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 14,436 | +14,436 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,230 | +12,230 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 10,200 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 6,999 | 15,636 | +8,637 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 321 | 8,661 | +8,340 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 327,955 | 330,787 | +2,832 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,671 | +2,671 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 157 | +157 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 13,236 | 13,275 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 40 | 41 | +1 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 4,387 | 4,387 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 102,000 | 102,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 4,309,860 | 4,309,860 | 0 | 10.84 | 19.08 | +8.24 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,681,307 | 6,681,307 | 0 | 0.12 | 0.16 | +0.04 | hold |
| HBK Sorce Advisory LLC | 13,227 | 13,227 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Plante Moran Financial Advisors, LLC | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFM Health Sciences, LP | 401,110 | 401,110 | 0 | 0.04 | 0.07 | +0.03 | hold |
| Alyeska Investment Group, L.P. | 235,705 | 235,705 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | 626,810 | 0 | 0.18 | 0.29 | +0.11 | hold |
| Regal Investment Advisors LLC | 27,204 | 27,204 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MPM BioImpact LLC | 2,408,810 | 2,408,810 | 0 | 0.45 | 0.78 | +0.32 | hold |
| Larson Financial Group LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CERTUITY, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TFC Financial Management, Inc. | 2,500 | 2,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DC Funds, LP | 589,102 | 589,102 | 0 | 29.83 | 37.32 | +7.49 | hold |
| Financial Perspectives, Inc | 6,750 | 6,750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rossby Financial, LCC | 860 | 860 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 11,284 | 11,284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 65,836 | 65,836 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EDGEWOOD MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 119,168 | 119,168 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,375 | 1,375 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 167 | 35 | -132 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 403 | 0 | -403 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 42,480 | 39,859 | -2,621 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,613 | 793 | -2,820 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 40,000 | 36,000 | -4,000 | 0.00 | 0.00 | +0.00 | sell |
| HIGHLINE WEALTH PARTNERS LLC | 10,000 | 5,000 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 8,448 | 1,569 | -6,879 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 20,126 | 13,016 | -7,110 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 14,377 | 6,004 | -8,373 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 11,345 | 0 | -11,345 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 44,261 | 29,250 | -15,011 | 0.00 | 0.00 | +0.00 | sell |
| Savant Capital, LLC | 21,275 | 0 | -21,275 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 56,600 | 34,600 | -22,000 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 22,409 | 0 | -22,409 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 45,422 | 20,139 | -25,283 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 25,791 | 0 | -25,791 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 26,983 | 0 | -26,983 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 61,277 | 34,285 | -26,992 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 92,168 | 17,807 | -74,361 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 84,421 | 0 | -84,421 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 103,785 | 0 | -103,785 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 374,939 | 268,577 | -106,362 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 227,442 | 60,341 | -167,101 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 361,983 | 101,323 | -260,660 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 2,129,024 | 1,830,292 | -298,732 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 696,695 | 317,053 | -379,642 | 0.00 | 0.00 | -0.00 | sell |