| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,597 | 3,034,255 | +2,033,658 | 0.00 | 0.02 | +0.02 | buy |
| PFM Health Sciences, LP | 2,558,282 | 3,468,177 | +909,895 | 0.26 | 0.80 | +0.54 | buy |
| BANK OF AMERICA CORP /DE/ | 1,531,924 | 2,096,081 | +564,157 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 547,651 | 873,438 | +325,787 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 177,300 | +177,300 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 146,736 | +146,736 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 45,200 | 107,506 | +62,306 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 397,808 | 435,705 | +37,897 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 50,768 | 83,468 | +32,700 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 26,067 | 49,648 | +23,581 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 22,472 | +22,472 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 21,522 | +21,522 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 20,383 | +20,383 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 174,250 | 194,308 | +20,058 | 0.00 | 0.00 | +0.00 | buy |
| CERTUITY, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 58,128 | 62,923 | +4,795 | 0.00 | 0.00 | +0.00 | buy |
| Financial Perspectives, Inc | 3,750 | 6,750 | +3,000 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 2 | 2,384 | +2,382 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,400 | 15,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 4,284,172 | 4,284,172 | 0 | 4.91 | 8.13 | +3.22 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,144,881 | 6,144,881 | 0 | 0.26 | 0.37 | +0.11 | hold |
| HBK Sorce Advisory LLC | 26,454 | 26,454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 626,810 | 626,810 | 0 | 0.32 | 0.45 | +0.13 | hold |
| MPM BioImpact LLC | 2,388,011 | 2,388,011 | 0 | 1.36 | 2.16 | +0.79 | hold |
| Rubric Capital Management LP | 1,935,357 | 1,935,357 | 0 | 0.17 | 0.28 | +0.10 | hold |
| DC Funds, LP | 589,102 | 589,102 | 0 | 25.95 | 27.34 | +1.39 | hold |
| EDGEWOOD MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 78,671 | 78,671 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GHP Investment Advisors, Inc. | 80 | 0 | -80 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 5,955 | 5,698 | -257 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,350 | 0 | -2,350 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,511 | 85,086 | -10,425 | 0.00 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 466,622 | 444,359 | -22,263 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 174,724 | 0 | -174,724 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 522,900 | 79,213 | -443,687 | 0.03 | 0.01 | -0.02 | sell |