| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 0 | 4,500,000 | +4,500,000 | 0.00 | 0.50 | +0.50 | buy |
| Lynx1 Capital Management LP | 379,159 | 4,845,871 | +4,466,712 | 0.15 | 1.68 | +1.53 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 604,678 | 961,271 | +356,593 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 264,266 | +264,266 | 0.00 | 0.06 | +0.06 | buy |
| FIDUCIARY TRUST CO | 115,000 | 215,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 788,175 | 865,739 | +77,564 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,018,882 | 2,071,538 | +52,656 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 332,203 | 384,278 | +52,075 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 417,734 | 469,306 | +51,572 | 0.22 | 0.32 | +0.10 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 506,600 | 556,142 | +49,542 | 0.01 | 0.02 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 21,990 | +21,990 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 28,429 | 42,963 | +14,534 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 11,290 | +11,290 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 76,885 | 84,267 | +7,382 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 783 | +783 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 26,896 | 26,954 | +58 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 10,124,576 | 10,124,576 | 0 | 0.20 | 0.25 | +0.05 | hold |
| RHUMBLINE ADVISERS | 783 | 783 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 142,807 | 142,807 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 201,153 | 201,153 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marquette Asset Management, LLC | 85,500 | 85,500 | 0 | 0.02 | 0.02 | +0.00 | hold |
| CWM, LLC | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Versant Venture Management, LLC | 4,959,769 | 4,959,769 | 0 | 1.29 | 6.49 | +5.20 | hold |
| New Leaf Venture Partners, L.L.C. | 2,497,922 | 2,497,922 | 0 | 2.03 | 2.95 | +0.92 | hold |
| Qube Research & Technologies Ltd | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cresset Asset Management, LLC | 23,725 | 23,725 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DLK Investment Management, LLC | 64,000 | 64,000 | 0 | 0.03 | 0.04 | +0.01 | hold |
| BARCLAYS PLC | 13,153 | 13,153 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 47 | 47 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 123,873 | 123,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighTower Advisors, LLC | 22,264 | 21,763 | -501 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 4,798 | 3,969 | -829 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 210,500 | 209,600 | -900 | 0.00 | 0.00 | +0.00 | sell |
| Steward Partners Investment Advisory, LLC | 1,010 | 0 | -1,010 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 2,089 | 0 | -2,089 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 5,010 | 10 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 13,647 | 0 | -13,647 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,223,351 | 1,205,524 | -17,827 | 0.00 | 0.00 | +0.00 | sell |
| Scientech Research LLC | 18,853 | 0 | -18,853 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA SECURITIES, LLC | 40,327 | 0 | -40,327 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 62,021 | 21,070 | -40,951 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 67,704 | 25,425 | -42,279 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 311,713 | 221,552 | -90,161 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 581,257 | 141,435 | -439,822 | 0.09 | 0.03 | -0.07 | sell |
| Erste Asset Management GmbH | 2,960,800 | 2,455,800 | -505,000 | 0.04 | 0.05 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,400,000 | 1,500,000 | -900,000 | 0.22 | 0.21 | -0.01 | sell |