| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SIMPLEX TRADING, LLC | 575 | 82,346 | +81,771 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 62,476 | 111,981 | +49,505 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 45,402 | +45,402 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,381,476 | 1,410,276 | +28,800 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 531,565 | 546,101 | +14,536 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 11,934 | +11,934 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 2,369 | 5,278 | +2,909 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 15,523 | 18,346 | +2,823 | 0.00 | 0.00 | -0.00 | buy |
| Banque Transatlantique SA | 0 | 305 | +305 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 64,099 | 64,141 | +42 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 2,071,538 | 2,071,538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MAI Capital Management | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 142,807 | 142,807 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 186 | 186 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | 1,500,000 | 0 | 0.06 | 0.03 | -0.03 | hold |
| New Leaf Venture Partners, L.L.C. | 2,497,922 | 2,497,922 | 0 | 1.89 | 1.96 | +0.07 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Lynx1 Capital Management LP | 9,256,953 | 9,256,953 | 0 | 1.97 | 1.17 | -0.80 | hold |
| Vestal Point Capital, LP | 6,100,000 | 6,100,000 | 0 | 0.21 | 0.15 | -0.05 | hold |
| Farther Finance Advisors, LLC | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DLK Investment Management, LLC | 53,000 | 53,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LRI Investments, LLC | 225 | 225 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 2,455,800 | 2,455,800 | 0 | 0.02 | 0.01 | -0.01 | hold |
| FIDUCIARY TRUST CO | 215,000 | 215,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 60 | 60 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 47 | 47 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 156,773 | 156,773 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 5 | 0 | -5 | 0.00 | 0.00 | 0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 49,364 | 46,955 | -2,409 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 722,296 | 718,450 | -3,846 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 13,153 | 4,224 | -8,929 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 942,900 | 933,764 | -9,136 | 0.00 | 0.00 | -0.00 | sell |
| Atria Wealth Solutions, Inc. | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 10,286 | 0 | -10,286 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 148,607 | 136,224 | -12,383 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 13,850 | 0 | -13,850 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 27,068 | 11,596 | -15,472 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 21,054 | 0 | -21,054 | 0.00 | 0.00 | -0.00 | sell |
| Ground Swell Capital, LLC | 25,424 | 0 | -25,424 | 0.03 | 0.00 | -0.03 | sell |
| Tower Research Capital LLC (TRC) | 54,479 | 6,316 | -48,163 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 556,142 | 506,142 | -50,000 | 0.01 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 225,261 | 146,717 | -78,544 | 0.03 | 0.02 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 7,404,869 | 7,034,626 | -370,243 | 0.09 | 0.06 | -0.03 | sell |