| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 4,500,000 | 6,052,000 | +1,552,000 | 0.50 | 0.36 | -0.14 | buy |
| Lynx1 Capital Management LP | 4,845,871 | 5,057,629 | +211,758 | 1.68 | 1.45 | -0.23 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 384,278 | 431,110 | +46,832 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 13,203 | +13,203 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 469,306 | 471,812 | +2,506 | 0.32 | 0.20 | -0.12 | buy |
| Global Retirement Partners, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 26,954 | 27,233 | +279 | 0.00 | 0.00 | -0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,071,538 | 2,071,538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 10,124,576 | 10,124,576 | 0 | 0.25 | 0.16 | -0.09 | hold |
| FEDERATED HERMES, INC. | 783 | 783 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 556,142 | 556,142 | 0 | 0.02 | 0.01 | -0.01 | hold |
| RHUMBLINE ADVISERS | 783 | 783 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 142,807 | 142,807 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | 1,500,000 | 0 | 0.21 | 0.12 | -0.09 | hold |
| Marquette Asset Management, LLC | 85,500 | 85,500 | 0 | 0.02 | 0.01 | -0.01 | hold |
| CWM, LLC | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 2,497,922 | 2,497,922 | 0 | 2.95 | 2.41 | -0.54 | hold |
| Qube Research & Technologies Ltd | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cresset Asset Management, LLC | 23,725 | 23,725 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 264,266 | 264,266 | 0 | 0.06 | 0.03 | -0.02 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DLK Investment Management, LLC | 64,000 | 64,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| LRI Investments, LLC | 225 | 225 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 2,455,800 | 2,455,800 | 0 | 0.05 | 0.03 | -0.02 | hold |
| BARCLAYS PLC | 13,153 | 13,153 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIDUCIARY TRUST CO | 215,000 | 215,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 961,271 | 961,271 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 47 | 47 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 123,873 | 123,873 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 21,070 | 21,054 | -16 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 21,763 | 21,512 | -251 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 3,969 | 0 | -3,969 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 11,290 | 0 | -11,290 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 84,267 | 64,512 | -19,755 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 21,990 | 0 | -21,990 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 25,425 | 0 | -25,425 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 42,963 | 17,039 | -25,924 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 221,552 | 158,261 | -63,291 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,205,524 | 1,125,574 | -79,950 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 201,153 | 103,854 | -97,299 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 865,739 | 750,926 | -114,813 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 141,435 | 0 | -141,435 | 0.03 | 0.00 | -0.03 | sell |
| TWO SIGMA ADVISERS, LP | 209,600 | 0 | -209,600 | 0.00 | 0.00 | -0.00 | sell |
| Versant Venture Management, LLC | 4,959,769 | 4,026,417 | -933,352 | 6.49 | 4.14 | -2.36 | sell |