| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RITHOLTZ WEALTH MANAGEMENT | 0 | 25,392 | +25,392 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,316 | 29,279 | +22,963 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 45,402 | 60,889 | +15,487 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,724 | +11,724 | 0.00 | 0.00 | +0.00 | buy |
| DLK Investment Management, LLC | 53,000 | 61,000 | +8,000 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,410,276 | 1,416,399 | +6,123 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 2,896 | +2,896 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 82,346 | 82,983 | +637 | 0.00 | 0.00 | -0.00 | buy |
| LRI Investments, LLC | 0 | 225 | +225 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 46,955 | 47,156 | +201 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 111,981 | 112,056 | +75 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 186 | 225 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Mid-American Wealth Advisory Group, Inc. | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 142,807 | 142,807 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | 1,500,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Mariner, LLC | 11,934 | 11,934 | 0 | 0.00 | 0.00 | -0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 2,497,922 | 2,497,922 | 0 | 1.96 | 37.74 | +35.78 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Lynx1 Capital Management LP | 9,256,953 | 9,256,953 | 0 | 1.17 | 1.07 | -0.10 | hold |
| Vestal Point Capital, LP | 6,100,000 | 6,100,000 | 0 | 0.15 | 0.13 | -0.03 | hold |
| Erste Asset Management GmbH | 2,455,800 | 2,455,800 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BARCLAYS PLC | 4,224 | 4,224 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIDUCIARY TRUST CO | 215,000 | 215,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 933,764 | 933,764 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 47 | 47 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 156,773 | 156,773 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| HARBOUR INVESTMENTS, INC. | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| LRI Investments, LLC | 225 | 0 | -225 | 0.00 | 0.00 | -0.00 | sell |
| Banque Transatlantique SA | 305 | 0 | -305 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 4,000 | 0 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 5,278 | 0 | -5,278 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 546,101 | 538,578 | -7,523 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 11,596 | 0 | -11,596 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 18,346 | 0 | -18,346 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,071,538 | 2,040,564 | -30,974 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 64,141 | 0 | -64,141 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 506,142 | 416,042 | -90,100 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 718,450 | 594,869 | -123,581 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 136,224 | 10,733 | -125,491 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 146,717 | 0 | -146,717 | 0.02 | 0.00 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 7,034,626 | 6,055,300 | -979,326 | 0.06 | 0.06 | +0.00 | sell |