| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 5,057,629 | 8,426,955 | +3,369,326 | 1.45 | 2.09 | +0.64 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,125,574 | 1,392,846 | +267,272 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 158,261 | 402,525 | +244,264 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 92,256 | +92,256 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 431,110 | 509,516 | +78,406 | 0.00 | 0.00 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 53,915 | +53,915 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 6,052,000 | 6,100,000 | +48,000 | 0.36 | 0.34 | -0.02 | buy |
| Engineers Gate Manager LP | 0 | 34,770 | +34,770 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 27,927 | +27,927 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 21,635 | +21,635 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 17,039 | 29,590 | +12,551 | 0.00 | 0.00 | +0.00 | buy |
| Nordwand Advisors, LLC | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 21,054 | 22,852 | +1,798 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 64 | +64 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,071,538 | 2,071,538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 783 | 783 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 556,142 | 556,142 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RBF Capital, LLC | 142,807 | 142,807 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | 1,500,000 | 0 | 0.12 | 0.08 | -0.05 | hold |
| CWM, LLC | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 2,497,922 | 2,497,922 | 0 | 2.41 | 1.80 | -0.62 | hold |
| Cresset Asset Management, LLC | 23,725 | 23,725 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DLK Investment Management, LLC | 64,000 | 64,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| LRI Investments, LLC | 225 | 225 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 2,455,800 | 2,455,800 | 0 | 0.03 | 0.02 | -0.01 | hold |
| BARCLAYS PLC | 13,153 | 13,153 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIDUCIARY TRUST CO | 215,000 | 215,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 60 | 60 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 961,271 | 961,271 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 47 | 47 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 123,873 | 123,873 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 27,233 | 27,072 | -161 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 783 | 0 | -783 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 21,512 | 16,380 | -5,132 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 103,854 | 98,041 | -5,813 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,203 | 5,030 | -8,173 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 64,512 | 40,281 | -24,231 | 0.00 | 0.00 | -0.00 | sell |
| Marquette Asset Management, LLC | 85,500 | 0 | -85,500 | 0.01 | 0.00 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 264,266 | 0 | -264,266 | 0.03 | 0.00 | -0.03 | sell |
| ORBIMED ADVISORS LLC | 10,124,576 | 9,822,876 | -301,700 | 0.16 | 0.13 | -0.03 | sell |
| Acuitas Investments, LLC | 471,812 | 0 | -471,812 | 0.20 | 0.00 | -0.20 | sell |
| MILLENNIUM MANAGEMENT LLC | 750,926 | 163,859 | -587,067 | 0.00 | 0.00 | -0.00 | sell |
| Versant Venture Management, LLC | 4,026,417 | 0 | -4,026,417 | 4.14 | 0.00 | -4.14 | sell |