| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 0 | 623,704 | +623,704 | 0.00 | 1.02 | +1.02 | buy |
| Vestal Point Capital, LP | 0 | 305,000 | +305,000 | 0.00 | 0.11 | +0.11 | buy |
| Erste Asset Management GmbH | 0 | 122,790 | +122,790 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 0 | 117,030 | +117,030 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 100,789 | +100,789 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 75,000 | +75,000 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 0 | 59,046 | +59,046 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 0 | 29,749 | +29,749 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 27,283 | +27,283 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 25,568 | +25,568 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 23,500 | +23,500 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 20,803 | +20,803 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 0 | 10,750 | +10,750 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 289 | +289 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 212 | +212 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| TSFG, LLC | 0 | 5 | +5 | 0.00 | 0.00 | 0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Mid-American Wealth Advisory Group, Inc. | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 47 | 0 | -47 | 0.00 | 0.00 | -0.00 | sell |
| TSFG, LLC | 100 | 0 | -100 | 0.00 | 0.00 | 0.00 | sell |
| LRI Investments, LLC | 225 | 12 | -213 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 225 | 0 | -225 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 2,896 | 142 | -2,754 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 4,224 | 0 | -4,224 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 10,733 | 0 | -10,733 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 11,724 | 0 | -11,724 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 11,934 | 0 | -11,934 | 0.00 | 0.00 | -0.00 | sell |
| RITHOLTZ WEALTH MANAGEMENT | 25,392 | 0 | -25,392 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 29,279 | 0 | -29,279 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 47,156 | 0 | -47,156 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 60,889 | 0 | -60,889 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 61,000 | 0 | -61,000 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 82,983 | 0 | -82,983 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 112,056 | 0 | -112,056 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 142,807 | 0 | -142,807 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 156,773 | 0 | -156,773 | 0.00 | 0.00 | -0.00 | sell |
| FIDUCIARY TRUST CO | 215,000 | 0 | -215,000 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 416,042 | 0 | -416,042 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 538,578 | 0 | -538,578 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 594,869 | 0 | -594,869 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 933,764 | 0 | -933,764 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,416,399 | 0 | -1,416,399 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,500,000 | 0 | -1,500,000 | 0.03 | 0.00 | -0.03 | sell |
| VANGUARD GROUP INC | 2,040,564 | 0 | -2,040,564 | 0.00 | 0.00 | -0.00 | sell |
| New Leaf Venture Partners, L.L.C. | 2,497,922 | 87,426 | -2,410,496 | 37.74 | 1.63 | -36.11 | sell |
| Erste Asset Management GmbH | 2,455,800 | 0 | -2,455,800 | 0.01 | 0.00 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 6,055,300 | 0 | -6,055,300 | 0.06 | 0.00 | -0.06 | sell |
| Vestal Point Capital, LP | 6,100,000 | 0 | -6,100,000 | 0.13 | 0.00 | -0.13 | sell |
| Lynx1 Capital Management LP | 9,256,953 | 0 | -9,256,953 | 1.07 | 0.00 | -1.07 | sell |