| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 400,000 | 2,400,000 | +2,000,000 | 0.04 | 0.22 | +0.19 | buy |
| MILLENNIUM MANAGEMENT LLC | 116,416 | 788,175 | +671,759 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 2,360,800 | 2,960,800 | +600,000 | 0.03 | 0.04 | +0.02 | buy |
| Pale Fire Capital SE | 98,662 | 581,257 | +482,595 | 0.01 | 0.09 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 994,399 | 1,223,351 | +228,952 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 103,499 | 311,713 | +208,214 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 190,124 | 379,159 | +189,035 | 0.08 | 0.15 | +0.07 | buy |
| Virtu Financial LLC | 0 | 67,704 | +67,704 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 40,327 | +40,327 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 53,113 | 76,885 | +23,772 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 21,424 | 28,429 | +7,005 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 0 | 4,798 | +4,798 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,089 | +2,089 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 20,435 | 22,264 | +1,829 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,017,883 | 2,018,882 | +999 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 10,124,576 | 10,124,576 | 0 | 0.14 | 0.20 | +0.06 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 506,600 | 506,600 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RHUMBLINE ADVISERS | 783 | 783 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 142,807 | 142,807 | 0 | 0.01 | 0.01 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 332,203 | 332,203 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 13,647 | 13,647 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Versant Venture Management, LLC | 4,959,769 | 4,959,769 | 0 | 1.73 | 1.29 | -0.45 | hold |
| New Leaf Venture Partners, L.L.C. | 2,497,922 | 2,497,922 | 0 | 2.12 | 2.03 | -0.08 | hold |
| Steward Partners Investment Advisory, LLC | 1,010 | 1,010 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cresset Asset Management, LLC | 23,725 | 23,725 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 13,153 | 13,153 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 62,021 | 62,021 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIDUCIARY TRUST CO | 115,000 | 115,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 604,678 | 604,678 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 47 | 47 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 123,873 | 123,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Acuitas Investments, LLC | 418,161 | 417,734 | -427 | 0.16 | 0.22 | +0.06 | sell |
| US BANCORP \DE\ | 500 | 0 | -500 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 511 | 0 | -511 | 0.00 | 0.00 | -0.00 | sell |
| Marquette Asset Management, LLC | 86,050 | 85,500 | -550 | 0.01 | 0.02 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 27,449 | 26,896 | -553 | 0.00 | 0.00 | +0.00 | sell |
| Federation des caisses Desjardins du Quebec | 8,010 | 5,010 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 10,026 | 0 | -10,026 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,725 | 0 | -13,725 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 228,254 | 201,153 | -27,101 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 240,200 | 210,500 | -29,700 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 74,046 | 0 | -74,046 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,758,219 | 0 | -1,758,219 | 0.08 | 0.00 | -0.08 | sell |
| BML Capital Management, LLC | 2,058,767 | 0 | -2,058,767 | 1.25 | 0.00 | -1.25 | sell |