| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 2,042,000 | +2,042,000 | 0.00 | 1.01 | +1.01 | buy |
| D. E. Shaw & Co., Inc. | 2,496,222 | 3,949,609 | +1,453,387 | 0.05 | 0.06 | +0.02 | buy |
| BlackRock, Inc. | 9,200,411 | 10,545,466 | +1,345,055 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 15,606 | 1,160,014 | +1,144,408 | 0.00 | 0.02 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,050,934 | +1,050,934 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 5,666,940 | 6,606,945 | +940,005 | 0.58 | 0.49 | -0.09 | buy |
| BANK OF AMERICA CORP /DE/ | 2,221,289 | 2,987,431 | +766,142 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 49,333 | 564,072 | +514,739 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,463,228 | 1,925,031 | +461,803 | 0.02 | 0.02 | +0.00 | buy |
| Aberdeen Group plc | 645,066 | 1,098,411 | +453,345 | 0.02 | 0.04 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 234,307 | 663,877 | +429,570 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 392,300 | +392,300 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 344,796 | +344,796 | 0.00 | 0.26 | +0.26 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 503,856 | 811,752 | +307,896 | 0.01 | 0.02 | +0.01 | buy |
| GW&K Investment Management, LLC | 988,387 | 1,288,018 | +299,631 | 0.21 | 0.26 | +0.06 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 243,119 | +243,119 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 0 | 242,069 | +242,069 | 0.00 | 0.55 | +0.55 | buy |
| MORGAN STANLEY | 4,218,931 | 4,451,014 | +232,083 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 50,460 | 260,033 | +209,573 | 0.01 | 0.03 | +0.03 | buy |
| Perpetual Ltd | 909,546 | 1,109,657 | +200,111 | 0.33 | 0.42 | +0.09 | buy |
| AMERIPRISE FINANCIAL INC | 101,674 | 295,997 | +194,323 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 49,567 | 235,471 | +185,904 | 0.02 | 0.06 | +0.04 | buy |
| BAMCO INC /NY/ | 1,072,189 | 1,253,120 | +180,931 | 0.08 | 0.05 | -0.03 | buy |
| Holocene Advisors, LP | 0 | 163,732 | +163,732 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 131,914 | +131,914 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 100,902 | 230,905 | +130,003 | 0.01 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 139,843 | 264,907 | +125,064 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 34,610 | 153,242 | +118,632 | 0.00 | 0.01 | +0.01 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,327,000 | 12,437,000 | +110,000 | 7.88 | 6.85 | -1.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,179 | 219,815 | +107,636 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 48,337 | 151,394 | +103,057 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 366,000 | 466,000 | +100,000 | 0.01 | 0.02 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 86,027 | +86,027 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 976,512 | 1,058,575 | +82,063 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 320,972 | 399,367 | +78,395 | 1.57 | 1.92 | +0.35 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 75,572 | +75,572 | 0.00 | 0.04 | +0.04 | buy |
| Jain Global LLC | 0 | 73,141 | +73,141 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 1,603,013 | 1,668,367 | +65,354 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 138,112 | 200,275 | +62,163 | 0.00 | 0.01 | +0.00 | buy |
| CenterBook Partners LP | 0 | 60,943 | +60,943 | 0.00 | 0.08 | +0.08 | buy |
| Magnetar Financial LLC | 0 | 56,082 | +56,082 | 0.00 | 0.01 | +0.01 | buy |
| Aquatic Capital Management LLC | 34,607 | 86,130 | +51,523 | 0.02 | 0.08 | +0.05 | buy |
| FEDERATED HERMES, INC. | 1,077,267 | 1,124,629 | +47,362 | 0.04 | 0.04 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,012,555 | 1,050,934 | +38,379 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 38,178 | +38,178 | 0.00 | 0.17 | +0.17 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 36,200 | +36,200 | 0.00 | 0.00 | +0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 35,148 | +35,148 | 0.00 | 0.01 | +0.01 | buy |
| WESBANCO BANK INC | 48,500 | 81,100 | +32,600 | 0.03 | 0.05 | +0.02 | buy |
| Man Group plc | 64,219 | 94,272 | +30,053 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 566,730 | 595,005 | +28,275 | 1.19 | 1.24 | +0.05 | buy |
| FMR LLC | 278,736 | 305,969 | +27,233 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 305,532 | 330,094 | +24,562 | 0.00 | 0.00 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 175,870 | 199,683 | +23,813 | 0.09 | 0.11 | +0.02 | buy |
| Tidal Investments LLC | 0 | 23,118 | +23,118 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 0 | 19,032 | +19,032 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 28,965 | 47,625 | +18,660 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 29,092 | 47,698 | +18,606 | 0.19 | 0.29 | +0.10 | buy |
| SG Americas Securities, LLC | 39,826 | 58,259 | +18,433 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 118,223 | 136,393 | +18,170 | 0.00 | 0.00 | -0.00 | buy |
| Advisors Asset Management, Inc. | 79,116 | 95,934 | +16,818 | 0.03 | 0.04 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 16,436 | +16,436 | 0.00 | 0.00 | +0.00 | buy |
| Yorktown Management & Research Co Inc | 0 | 16,000 | +16,000 | 0.00 | 0.26 | +0.26 | buy |
| Legal & General Group Plc | 84,877 | 100,808 | +15,931 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 15,290 | +15,290 | 0.00 | 0.04 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 168,826 | 183,662 | +14,836 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 12,805 | +12,805 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 12,763 | +12,763 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 12,639 | +12,639 | 0.00 | 0.03 | +0.03 | buy |
| Bridgefront Capital, LLC | 0 | 11,825 | +11,825 | 0.00 | 0.08 | +0.08 | buy |
| Diametric Capital, LP | 0 | 10,531 | +10,531 | 0.00 | 0.03 | +0.03 | buy |
| Graham Capital Management, L.P. | 0 | 10,022 | +10,022 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 161,131 | 170,542 | +9,411 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 8,996 | +8,996 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 8,657 | +8,657 | 0.00 | 0.07 | +0.07 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 8,485 | +8,485 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON ASSOCIATES LLP | 0 | 8,374 | +8,374 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 7,813 | +7,813 | 0.00 | 0.00 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 1,365,941 | 1,372,941 | +7,000 | 0.95 | 0.74 | -0.21 | buy |
| DnB Asset Management AS | 25,401 | 32,393 | +6,992 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 4,543 | 11,084 | +6,541 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88,484 | 94,638 | +6,154 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 5,953 | +5,953 | 0.00 | 0.00 | +0.00 | buy |
| NAVELLIER & ASSOCIATES INC | 13,753 | 19,696 | +5,943 | 0.03 | 0.04 | +0.01 | buy |
| Swiss National Bank | 218,200 | 224,000 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 60,975 | 66,629 | +5,654 | 0.01 | 0.01 | +0.00 | buy |
| Arax Advisory Partners | 573 | 5,432 | +4,859 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 21,400 | 26,100 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 29,244 | 33,752 | +4,508 | 0.01 | 0.01 | +0.00 | buy |
| Entropy Technologies, LP | 17,964 | 22,285 | +4,321 | 0.02 | 0.02 | +0.00 | buy |
| FIDUCIARY TRUST CO | 10,620 | 14,712 | +4,092 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 21,947 | 26,019 | +4,072 | 0.05 | 0.03 | -0.02 | buy |
| Creative Planning | 29,651 | 33,565 | +3,914 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 12,631 | 16,425 | +3,794 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 3,329,224 | 3,333,015 | +3,791 | 0.01 | 0.01 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 17,597 | 21,105 | +3,508 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 3,190 | +3,190 | 0.00 | 0.00 | +0.00 | buy |
| Bayforest Capital Ltd | 0 | 3,004 | +3,004 | 0.00 | 0.07 | +0.07 | buy |
| JONES FINANCIAL COMPANIES LLLP | 14,033 | 17,022 | +2,989 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 18,890 | 21,801 | +2,911 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 42,684 | 45,545 | +2,861 | 0.02 | 0.02 | -0.00 | buy |