| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 1,525,045 | 8,784,038 | +7,258,993 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 4,234,951 | +4,234,951 | 0.00 | 0.52 | +0.52 | buy |
| JENNISON ASSOCIATES LLC | 9,066,082 | 12,176,315 | +3,110,233 | 0.02 | 0.08 | +0.06 | buy |
| Cormorant Asset Management, LP | 0 | 2,125,000 | +2,125,000 | 0.00 | 0.93 | +0.93 | buy |
| CITADEL ADVISORS LLC | 0 | 1,914,270 | +1,914,270 | 0.00 | 0.02 | +0.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,780,000 | +1,780,000 | 0.00 | 0.10 | +0.10 | buy |
| BRAIDWELL LP | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.42 | +0.42 | buy |
| J. Goldman & Co LP | 167,733 | 1,435,318 | +1,267,585 | 0.03 | 0.64 | +0.61 | buy |
| Ensign Peak Advisors, Inc | 2,029,957 | 2,980,347 | +950,390 | 0.01 | 0.05 | +0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 943,467 | +943,467 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 71,465 | 1,000,206 | +928,741 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 6,644,530 | 7,510,000 | +865,470 | 0.80 | 2.20 | +1.40 | buy |
| Invesco Ltd. | 25,136 | 872,344 | +847,208 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 822,461 | +822,461 | 0.00 | 0.03 | +0.03 | buy |
| Two Seas Capital LP | 0 | 809,332 | +809,332 | 0.00 | 1.57 | +1.57 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 780,780 | +780,780 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 91,018 | 850,529 | +759,511 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 750,000 | +750,000 | 0.00 | 0.13 | +0.13 | buy |
| CITIGROUP INC | 12,713 | 716,440 | +703,727 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 589,642 | +589,642 | 0.00 | 1.59 | +1.59 | buy |
| Polar Capital Holdings Plc | 6,297,688 | 6,885,922 | +588,234 | 0.13 | 0.36 | +0.23 | buy |
| EcoR1 Capital, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.13 | +0.13 | buy |
| UBS Group AG | 0 | 490,677 | +490,677 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,394,410 | 1,872,605 | +478,195 | 0.00 | 0.01 | +0.01 | buy |
| Tri Locum Partners LP | 0 | 449,694 | +449,694 | 0.00 | 1.55 | +1.55 | buy |
| Monashee Investment Management LLC | 0 | 380,000 | +380,000 | 0.00 | 0.45 | +0.45 | buy |
| Trexquant Investment LP | 0 | 362,869 | +362,869 | 0.00 | 0.07 | +0.07 | buy |
| HSBC HOLDINGS PLC | 143,935 | 506,286 | +362,351 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 0 | 345,239 | +345,239 | 0.00 | 0.17 | +0.17 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 330,900 | +330,900 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 0 | 320,226 | +320,226 | 0.00 | 0.30 | +0.30 | buy |
| VANGUARD GROUP INC | 4,896,513 | 5,166,417 | +269,904 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,743,589 | 1,971,433 | +227,844 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 225,000 | +225,000 | 0.00 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 225,000 | +225,000 | 0.00 | 0.20 | +0.20 | buy |
| ExodusPoint Capital Management, LP | 0 | 222,222 | +222,222 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 0 | 216,866 | +216,866 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 204,779 | +204,779 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 571,318 | 750,724 | +179,406 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 171,796 | +171,796 | 0.00 | 0.05 | +0.05 | buy |
| FISHMAN JAY A LTD/MI | 53,000 | 224,300 | +171,300 | 0.02 | 0.25 | +0.23 | buy |
| Cinctive Capital Management LP | 0 | 139,211 | +139,211 | 0.00 | 0.07 | +0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 911,803 | 1,040,946 | +129,143 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 126,283 | +126,283 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 120,493 | +120,493 | 0.00 | 0.06 | +0.06 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,910,009 | 2,028,008 | +117,999 | 1.56 | 12.92 | +11.35 | buy |
| NORGES BANK | 81,012 | 174,820 | +93,808 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,640,325 | 1,721,253 | +80,928 | 0.05 | 0.15 | +0.10 | buy |
| Capula Management Ltd | 0 | 79,968 | +79,968 | 0.00 | 0.03 | +0.03 | buy |
| Clearline Capital LP | 0 | 79,683 | +79,683 | 0.00 | 0.08 | +0.08 | buy |
| Caption Management, LLC | 0 | 79,500 | +79,500 | 0.00 | 0.09 | +0.09 | buy |
| GOLDMAN SACHS GROUP INC | 733,002 | 806,524 | +73,522 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 67,598 | +67,598 | 0.00 | 0.02 | +0.02 | buy |
| Focus Partners Wealth | 0 | 63,100 | +63,100 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 57,378 | +57,378 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 149,423 | 205,870 | +56,447 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 160,601 | 213,536 | +52,935 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 46,654 | +46,654 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 46,547 | +46,547 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 38,866 | +38,866 | 0.00 | 0.02 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 33,714 | +33,714 | 0.00 | 0.01 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 21,250 | +21,250 | 0.00 | 0.04 | +0.04 | buy |
| Frazier Life Sciences Management, L.P. | 8,764,232 | 8,785,284 | +21,052 | 1.51 | 3.67 | +2.16 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Koshinski Asset Management, Inc. | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 106,931 | 125,333 | +18,402 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 730,744 | 748,945 | +18,201 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 17,805 | +17,805 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,922 | 31,695 | +16,773 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 3,000 | 17,000 | +14,000 | 0.00 | 0.07 | +0.06 | buy |
| Quantbot Technologies LP | 0 | 12,200 | +12,200 | 0.00 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 0 | 11,100 | +11,100 | 0.00 | 0.02 | +0.02 | buy |
| GROUP ONE TRADING LLC | 51,686 | 60,347 | +8,661 | 0.01 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 10,920 | 18,614 | +7,694 | 0.01 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,260 | 74,700 | +7,440 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 21,268 | 28,626 | +7,358 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 35,224 | 42,524 | +7,300 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 11,398 | 18,135 | +6,737 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 6,452 | +6,452 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 42,842 | 48,997 | +6,155 | 0.01 | 0.03 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 21,614 | 27,758 | +6,144 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 3,875 | +3,875 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 3,519 | +3,519 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,071 | 7,871 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 1,876 | +1,876 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 19,120 | 20,990 | +1,870 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,419 | 12,175 | +1,756 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,072 | 47,753 | +1,681 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 18,420 | 19,125 | +705 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 466 | 1,048 | +582 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 10 | 279 | +269 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 90 | 339 | +249 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 9,523 | 9,764 | +241 | 0.00 | 0.00 | +0.00 | buy |
| MATHER GROUP, LLC. | 0 | 190 | +190 | 0.00 | 0.00 | +0.00 | buy |
| Park Place Capital Corp | 0 | 183 | +183 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 17,630 | 17,770 | +140 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 11,025 | 11,120 | +95 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |