| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 9,066,082 | 12,176,315 | +3,110,233 | 0.02 | 0.08 | +0.06 | buy |
| Frazier Life Sciences Management, L.P. | 8,764,232 | 8,785,284 | +21,052 | 1.51 | 3.67 | +2.16 | buy |
| STATE STREET CORP | 1,525,045 | 8,784,038 | +7,258,993 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 8,473,101 | 7,877,297 | -595,804 | 1.25 | 3.29 | +2.04 | sell |
| Rubric Capital Management LP | 6,644,530 | 7,510,000 | +865,470 | 0.80 | 2.20 | +1.40 | buy |
| Polar Capital Holdings Plc | 6,297,688 | 6,885,922 | +588,234 | 0.13 | 0.36 | +0.23 | buy |
| VANGUARD GROUP INC | 4,896,513 | 5,166,417 | +269,904 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 4,655,544 | 4,642,460 | -13,084 | 0.01 | 0.01 | +0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 0 | 4,234,951 | +4,234,951 | 0.00 | 0.52 | +0.52 | buy |
| MORGAN STANLEY | 6,083,072 | 4,006,335 | -2,076,737 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 2,029,957 | 2,980,347 | +950,390 | 0.01 | 0.05 | +0.04 | buy |
| STEMPOINT CAPITAL LP | 2,594,536 | 2,205,899 | -388,637 | 2.26 | 5.84 | +3.58 | sell |
| Cormorant Asset Management, LP | 0 | 2,125,000 | +2,125,000 | 0.00 | 0.93 | +0.93 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,910,009 | 2,028,008 | +117,999 | 1.56 | 12.92 | +11.35 | buy |
| Bain Capital Life Sciences Investors, LLC | 3,000,000 | 2,011,687 | -988,313 | 0.93 | 1.60 | +0.67 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,743,589 | 1,971,433 | +227,844 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 1,914,270 | +1,914,270 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 1,394,410 | 1,872,605 | +478,195 | 0.00 | 0.01 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,780,000 | +1,780,000 | 0.00 | 0.10 | +0.10 | buy |
| GW&K Investment Management, LLC | 1,640,325 | 1,721,253 | +80,928 | 0.05 | 0.15 | +0.10 | buy |
| J. Goldman & Co LP | 167,733 | 1,435,318 | +1,267,585 | 0.03 | 0.64 | +0.61 | buy |
| BRAIDWELL LP | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.42 | +0.42 | buy |
| AMERICAN CENTURY COMPANIES INC | 911,803 | 1,040,946 | +129,143 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 71,465 | 1,000,206 | +928,741 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 943,467 | +943,467 | 0.00 | 0.03 | +0.03 | buy |
| Tejara Capital Ltd | 1,112,217 | 940,487 | -171,730 | 1.50 | 3.45 | +1.95 | sell |
| Invesco Ltd. | 25,136 | 872,344 | +847,208 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 91,018 | 850,529 | +759,511 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 822,461 | +822,461 | 0.00 | 0.03 | +0.03 | buy |
| Two Seas Capital LP | 0 | 809,332 | +809,332 | 0.00 | 1.57 | +1.57 | buy |
| GOLDMAN SACHS GROUP INC | 733,002 | 806,524 | +73,522 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 780,780 | +780,780 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 571,318 | 750,724 | +179,406 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 750,000 | +750,000 | 0.00 | 0.13 | +0.13 | buy |
| NORTHERN TRUST CORP | 730,744 | 748,945 | +18,201 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 818,055 | 723,325 | -94,730 | 0.00 | 0.01 | +0.01 | sell |
| CITIGROUP INC | 12,713 | 716,440 | +703,727 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 635,969 | 635,969 | 0 | 0.53 | 2.19 | +1.67 | hold |
| Ikarian Capital, LLC | 0 | 589,642 | +589,642 | 0.00 | 1.59 | +1.59 | buy |
| HSBC HOLDINGS PLC | 143,935 | 506,286 | +362,351 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.13 | +0.13 | buy |
| UBS Group AG | 0 | 490,677 | +490,677 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 978,805 | 484,081 | -494,724 | 0.01 | 0.01 | +0.00 | sell |
| Tri Locum Partners LP | 0 | 449,694 | +449,694 | 0.00 | 1.55 | +1.55 | buy |
| Monashee Investment Management LLC | 0 | 380,000 | +380,000 | 0.00 | 0.45 | +0.45 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,558,880 | 379,051 | -2,179,829 | 0.01 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 362,869 | +362,869 | 0.00 | 0.07 | +0.07 | buy |
| FEDERATED HERMES, INC. | 521,469 | 350,114 | -171,355 | 0.00 | 0.01 | +0.00 | sell |
| AMI ASSET MANAGEMENT CORP | 0 | 345,239 | +345,239 | 0.00 | 0.17 | +0.17 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 330,900 | +330,900 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 0 | 320,226 | +320,226 | 0.00 | 0.30 | +0.30 | buy |
| Bank of New York Mellon Corp | 317,927 | 310,124 | -7,803 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 225,000 | +225,000 | 0.00 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 225,000 | +225,000 | 0.00 | 0.20 | +0.20 | buy |
| FISHMAN JAY A LTD/MI | 53,000 | 224,300 | +171,300 | 0.02 | 0.25 | +0.23 | buy |
| ExodusPoint Capital Management, LP | 0 | 222,222 | +222,222 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 0 | 216,866 | +216,866 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 160,601 | 213,536 | +52,935 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 149,423 | 205,870 | +56,447 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 204,779 | +204,779 | 0.00 | 0.02 | +0.02 | buy |
| NORGES BANK | 81,012 | 174,820 | +93,808 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 171,796 | +171,796 | 0.00 | 0.05 | +0.05 | buy |
| Pennant Investors, LP | 170,900 | 170,900 | 0 | 0.17 | 0.47 | +0.30 | hold |
| LPL Financial LLC | 189,643 | 158,205 | -31,438 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 148,874 | 148,874 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 194,461 | 148,433 | -46,028 | 0.00 | 0.01 | +0.00 | sell |
| FMR LLC | 1,222,404 | 141,098 | -1,081,306 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 140,000 | 140,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cinctive Capital Management LP | 0 | 139,211 | +139,211 | 0.00 | 0.07 | +0.07 | buy |
| PROFUND ADVISORS LLC | 0 | 126,283 | +126,283 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 106,931 | 125,333 | +18,402 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 120,493 | +120,493 | 0.00 | 0.06 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 328,877 | 100,221 | -228,656 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 108,660 | 98,505 | -10,155 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 1,079,580 | 93,940 | -985,640 | 0.00 | 0.00 | -0.00 | sell |
| Capula Management Ltd | 0 | 79,968 | +79,968 | 0.00 | 0.03 | +0.03 | buy |
| Clearline Capital LP | 0 | 79,683 | +79,683 | 0.00 | 0.08 | +0.08 | buy |
| Caption Management, LLC | 0 | 79,500 | +79,500 | 0.00 | 0.09 | +0.09 | buy |
| MYDA Advisors LLC | 220,000 | 75,000 | -145,000 | 0.30 | 0.26 | -0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 67,260 | 74,700 | +7,440 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 67,598 | +67,598 | 0.00 | 0.02 | +0.02 | buy |
| Focus Partners Wealth | 0 | 63,100 | +63,100 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 51,686 | 60,347 | +8,661 | 0.01 | 0.02 | +0.02 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 57,378 | +57,378 | 0.00 | 0.01 | +0.01 | buy |
| Parallax Volatility Advisers, L.P. | 275,264 | 53,525 | -221,739 | 0.02 | 0.02 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 42,842 | 48,997 | +6,155 | 0.01 | 0.03 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,072 | 47,753 | +1,681 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 46,654 | +46,654 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 46,547 | +46,547 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 43,801 | 43,801 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KEYBANK NATIONAL ASSOCIATION/OH | 35,224 | 42,524 | +7,300 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 39,311 | 38,976 | -335 | 0.00 | 0.00 | +0.00 | sell |
| E Fund Management Co., Ltd. | 0 | 38,866 | +38,866 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 74,854 | 36,548 | -38,306 | 0.02 | 0.03 | +0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 33,714 | +33,714 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 14,922 | 31,695 | +16,773 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 289,088 | 31,099 | -257,989 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,507 | 30,786 | -2,721 | 0.00 | 0.00 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 21,268 | 28,626 | +7,358 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 21,614 | 27,758 | +6,144 | 0.00 | 0.00 | +0.00 | buy |