| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,964,000 | 12,327,000 | +363,000 | 8.66 | 7.88 | -0.79 | buy |
| Frazier Life Sciences Management, L.P. | 9,874,511 | 9,874,511 | 0 | 7.70 | 5.99 | -1.72 | hold |
| BlackRock, Inc. | 9,099,579 | 9,200,411 | +100,832 | 0.00 | 0.00 | -0.00 | buy |
| Rubric Capital Management LP | 8,271,577 | 8,271,577 | 0 | 2.87 | 2.39 | -0.49 | hold |
| STATE STREET CORP | 5,488,301 | 6,296,197 | +807,896 | 0.01 | 0.01 | -0.00 | buy |
| Polar Capital Holdings Plc | 5,556,169 | 5,666,940 | +110,771 | 0.74 | 0.58 | -0.15 | buy |
| JENNISON ASSOCIATES LLC | 6,758,006 | 4,980,770 | -1,777,236 | 0.12 | 0.08 | -0.04 | sell |
| GILDER GAGNON HOWE & CO LLC | 4,453,856 | 4,304,010 | -149,846 | 1.37 | 1.22 | -0.15 | sell |
| MORGAN STANLEY | 4,340,239 | 4,218,931 | -121,308 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 3,243,432 | 3,329,224 | +85,792 | 0.02 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,753,307 | 3,045,306 | +291,999 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,683,087 | 2,496,222 | -186,865 | 0.06 | 0.05 | -0.01 | sell |
| MARSHALL WACE, LLP | 454,233 | 2,431,778 | +1,977,545 | 0.01 | 0.06 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 1,900,084 | 2,297,943 | +397,859 | 0.01 | 0.01 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,562,445 | 2,226,029 | -336,416 | 0.51 | 0.39 | -0.12 | sell |
| BANK OF AMERICA CORP /DE/ | 1,673,454 | 2,221,289 | +547,835 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,830,061 | 1,854,566 | +24,505 | 0.02 | 0.02 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,576,413 | 1,603,013 | +26,600 | 0.01 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,467,176 | 1,463,228 | -3,948 | 0.02 | 0.02 | -0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 808,400 | 1,365,941 | +557,541 | 0.86 | 0.95 | +0.09 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,366,624 | 1,355,892 | -10,732 | 15.34 | 11.42 | -3.93 | sell |
| Ensign Peak Advisors, Inc | 1,902,390 | 1,244,387 | -658,003 | 0.10 | 0.05 | -0.04 | sell |
| Squarepoint Ops LLC | 455,876 | 1,103,490 | +647,614 | 0.03 | 0.06 | +0.03 | buy |
| Candriam S.C.A. | 803,138 | 1,086,651 | +283,513 | 0.12 | 0.13 | +0.02 | buy |
| FEDERATED HERMES, INC. | 891,767 | 1,077,267 | +185,500 | 0.04 | 0.04 | -0.00 | buy |
| BAMCO INC /NY/ | 504,700 | 1,072,189 | +567,489 | 0.04 | 0.08 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,014,826 | 1,012,555 | -2,271 | 0.00 | 0.00 | -0.00 | sell |
| GW&K Investment Management, LLC | 1,008,580 | 988,387 | -20,193 | 0.25 | 0.21 | -0.05 | sell |
| NORTHERN TRUST CORP | 955,235 | 976,512 | +21,277 | 0.00 | 0.00 | -0.00 | buy |
| Perpetual Ltd | 910,630 | 909,546 | -1,084 | 0.38 | 0.33 | -0.05 | sell |
| Nuveen, LLC | 1,382,160 | 902,134 | -480,026 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 699,803 | 812,146 | +112,343 | 0.01 | 0.01 | -0.00 | buy |
| MPM BioImpact LLC | 531,200 | 733,966 | +202,766 | 1.77 | 1.34 | -0.43 | buy |
| Qube Research & Technologies Ltd | 661,415 | 724,067 | +62,652 | 0.03 | 0.02 | -0.00 | buy |
| Aberdeen Group plc | 586,397 | 645,066 | +58,669 | 0.03 | 0.02 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 900,000 | 636,200 | -263,800 | 0.04 | 0.02 | -0.02 | sell |
| Nearwater Capital Markets, Ltd | 615,000 | 607,300 | -7,700 | 0.31 | 0.34 | +0.03 | sell |
| Point72 Asset Management, L.P. | 425,152 | 590,877 | +165,725 | 0.02 | 0.02 | +0.00 | buy |
| Eversept Partners, LP | 434,634 | 576,580 | +141,946 | 0.71 | 0.90 | +0.19 | buy |
| FISHMAN JAY A LTD/MI | 564,650 | 566,730 | +2,080 | 1.35 | 1.19 | -0.16 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 914,020 | 540,511 | -373,509 | 0.09 | 0.05 | -0.04 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 125,979 | 503,856 | +377,877 | 0.00 | 0.01 | +0.01 | buy |
| M&G Plc | 0 | 469,082 | +469,082 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 499,418 | 468,253 | -31,165 | 0.01 | 0.01 | -0.00 | sell |
| Cormorant Asset Management, LP | 500,000 | 450,000 | -50,000 | 0.82 | 0.53 | -0.29 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,166,348 | 448,207 | -718,141 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 273,999 | 440,999 | +167,000 | 0.01 | 0.02 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 224,740 | 413,792 | +189,052 | 1.12 | 1.87 | +0.75 | buy |
| Patient Square Capital LP | 210,000 | 400,645 | +190,645 | 1.31 | 1.67 | +0.37 | buy |
| DEUTSCHE BANK AG\ | 930,202 | 389,847 | -540,355 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 366,000 | +366,000 | 0.00 | 0.01 | +0.01 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 418,035 | 357,490 | -60,545 | 0.27 | 0.24 | -0.03 | sell |
| FIRST TRUST ADVISORS LP | 404,654 | 351,217 | -53,437 | 0.01 | 0.01 | -0.00 | sell |
| Penn Capital Management Company, LLC | 0 | 333,130 | +333,130 | 0.00 | 0.61 | +0.61 | buy |
| Privium Fund Management B.V. | 305,972 | 320,972 | +15,000 | 1.64 | 1.57 | -0.06 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 306,272 | +306,272 | 0.00 | 0.27 | +0.27 | buy |
| Bank of New York Mellon Corp | 304,428 | 305,532 | +1,104 | 0.00 | 0.00 | -0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 309,430 | 293,460 | -15,970 | 0.26 | 0.23 | -0.04 | sell |
| JANE STREET GROUP, LLC | 221,426 | 283,623 | +62,197 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 205,424 | 278,736 | +73,312 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 42,913 | 256,628 | +213,715 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 234,915 | 256,545 | +21,630 | 0.01 | 0.01 | -0.00 | buy |
| MYDA Advisors LLC | 265,000 | 240,000 | -25,000 | 2.17 | 1.33 | -0.83 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 231,734 | 237,171 | +5,437 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 400,862 | 234,307 | -166,555 | 0.02 | 0.00 | -0.01 | sell |
| Swiss National Bank | 212,800 | 218,200 | +5,400 | 0.00 | 0.00 | -0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 326,538 | 217,255 | -109,283 | 0.08 | 0.03 | -0.05 | sell |
| SEI INVESTMENTS CO | 104,286 | 206,141 | +101,855 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 284,243 | 197,810 | -86,433 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 195,033 | 195,033 | 0 | 0.02 | 0.02 | -0.00 | hold |
| NORDEA INVESTMENT MANAGEMENT AB | 201,638 | 192,920 | -8,718 | 0.01 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 234,071 | 190,014 | -44,057 | 0.01 | 0.01 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 179,420 | 188,220 | +8,800 | 0.14 | 0.12 | -0.02 | buy |
| Rafferty Asset Management, LLC | 172,066 | 183,024 | +10,958 | 0.02 | 0.02 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 113,385 | 175,870 | +62,485 | 0.07 | 0.09 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 168,826 | +168,826 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 0 | 166,191 | +166,191 | 0.00 | 1.29 | +1.29 | buy |
| RHUMBLINE ADVISERS | 161,402 | 161,131 | -271 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 155,075 | 155,075 | 0 | 0.29 | 0.22 | -0.08 | hold |
| LAZARD ASSET MANAGEMENT LLC | 93,354 | 154,566 | +61,212 | 0.00 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 64,503 | 154,422 | +89,919 | 0.01 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 144,949 | 149,867 | +4,918 | 0.00 | 0.00 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 141,271 | 143,934 | +2,663 | 0.63 | 0.54 | -0.09 | buy |
| Invesco Ltd. | 307,382 | 139,843 | -167,539 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 87,687 | 138,112 | +50,425 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 102,439 | 128,317 | +25,878 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 176,600 | 123,683 | -52,917 | 0.11 | 0.06 | -0.05 | sell |
| LPL Financial LLC | 111,874 | 119,381 | +7,507 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 116,360 | 118,223 | +1,863 | 0.00 | 0.00 | +0.00 | buy |
| 1492 Capital Management LLC | 0 | 118,156 | +118,156 | 0.00 | 1.06 | +1.06 | buy |
| JPMORGAN CHASE & CO | 106,488 | 112,954 | +6,466 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,867 | 112,179 | +103,312 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 57,136 | 104,356 | +47,220 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 98,826 | 101,674 | +2,848 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 99,247 | 100,902 | +1,655 | 0.01 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88,480 | 88,484 | +4 | 0.00 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 49,025 | 88,261 | +39,236 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 104,013 | 84,877 | -19,136 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 64,171 | 81,743 | +17,572 | 0.06 | 0.07 | +0.01 | buy |
| Advisors Asset Management, Inc. | 76,598 | 79,116 | +2,518 | 0.04 | 0.03 | -0.01 | buy |