| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MARSHALL WACE, LLP | 454,233 | 2,431,778 | +1,977,545 | 0.01 | 0.06 | +0.05 | buy |
| STATE STREET CORP | 5,488,301 | 6,296,197 | +807,896 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 455,876 | 1,103,490 | +647,614 | 0.03 | 0.06 | +0.03 | buy |
| BAMCO INC /NY/ | 504,700 | 1,072,189 | +567,489 | 0.04 | 0.08 | +0.04 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 808,400 | 1,365,941 | +557,541 | 0.86 | 0.95 | +0.09 | buy |
| BANK OF AMERICA CORP /DE/ | 1,673,454 | 2,221,289 | +547,835 | 0.00 | 0.00 | +0.00 | buy |
| M&G Plc | 0 | 469,082 | +469,082 | 0.00 | 0.06 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 1,900,084 | 2,297,943 | +397,859 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 125,979 | 503,856 | +377,877 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 366,000 | +366,000 | 0.00 | 0.01 | +0.01 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,964,000 | 12,327,000 | +363,000 | 8.66 | 7.88 | -0.79 | buy |
| Penn Capital Management Company, LLC | 0 | 333,130 | +333,130 | 0.00 | 0.61 | +0.61 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 306,272 | +306,272 | 0.00 | 0.27 | +0.27 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,753,307 | 3,045,306 | +291,999 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 803,138 | 1,086,651 | +283,513 | 0.12 | 0.13 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 42,913 | 256,628 | +213,715 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 531,200 | 733,966 | +202,766 | 1.77 | 1.34 | -0.43 | buy |
| Patient Square Capital LP | 210,000 | 400,645 | +190,645 | 1.31 | 1.67 | +0.37 | buy |
| STEMPOINT CAPITAL LP | 224,740 | 413,792 | +189,052 | 1.12 | 1.87 | +0.75 | buy |
| FEDERATED HERMES, INC. | 891,767 | 1,077,267 | +185,500 | 0.04 | 0.04 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 168,826 | +168,826 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 273,999 | 440,999 | +167,000 | 0.01 | 0.02 | +0.00 | buy |
| Tejara Capital Ltd | 0 | 166,191 | +166,191 | 0.00 | 1.29 | +1.29 | buy |
| Point72 Asset Management, L.P. | 425,152 | 590,877 | +165,725 | 0.02 | 0.02 | +0.00 | buy |
| Eversept Partners, LP | 434,634 | 576,580 | +141,946 | 0.71 | 0.90 | +0.19 | buy |
| 1492 Capital Management LLC | 0 | 118,156 | +118,156 | 0.00 | 1.06 | +1.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 699,803 | 812,146 | +112,343 | 0.01 | 0.01 | -0.00 | buy |
| Polar Capital Holdings Plc | 5,556,169 | 5,666,940 | +110,771 | 0.74 | 0.58 | -0.15 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,867 | 112,179 | +103,312 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 104,286 | 206,141 | +101,855 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 9,099,579 | 9,200,411 | +100,832 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 64,503 | 154,422 | +89,919 | 0.01 | 0.01 | +0.01 | buy |
| UBS Group AG | 3,243,432 | 3,329,224 | +85,792 | 0.02 | 0.01 | -0.00 | buy |
| FMR LLC | 205,424 | 278,736 | +73,312 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 661,415 | 724,067 | +62,652 | 0.03 | 0.02 | -0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 113,385 | 175,870 | +62,485 | 0.07 | 0.09 | +0.02 | buy |
| JANE STREET GROUP, LLC | 221,426 | 283,623 | +62,197 | 0.01 | 0.01 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 93,354 | 154,566 | +61,212 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 586,397 | 645,066 | +58,669 | 0.03 | 0.02 | -0.00 | buy |
| Man Group plc | 8,959 | 64,219 | +55,260 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 87,687 | 138,112 | +50,425 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 57,136 | 104,356 | +47,220 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 49,025 | 88,261 | +39,236 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 12,125 | 46,087 | +33,962 | 0.03 | 0.07 | +0.04 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 31,544 | +31,544 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 1,576,413 | 1,603,013 | +26,600 | 0.01 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 102,439 | 128,317 | +25,878 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 25,439 | +25,439 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 1,830,061 | 1,854,566 | +24,505 | 0.02 | 0.02 | -0.00 | buy |
| Quadrature Capital Ltd | 0 | 23,157 | +23,157 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 22,943 | +22,943 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 234,915 | 256,545 | +21,630 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 955,235 | 976,512 | +21,277 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 19,050 | +19,050 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 64,171 | 81,743 | +17,572 | 0.06 | 0.07 | +0.01 | buy |
| Trexquant Investment LP | 0 | 17,042 | +17,042 | 0.00 | 0.00 | +0.00 | buy |
| MFA Wealth Services | 0 | 16,196 | +16,196 | 0.00 | 0.25 | +0.25 | buy |
| AXQ CAPITAL, LP | 0 | 16,181 | +16,181 | 0.00 | 0.05 | +0.05 | buy |
| SIT INVESTMENT ASSOCIATES INC | 12,950 | 28,900 | +15,950 | 0.01 | 0.01 | +0.01 | buy |
| Stratos Wealth Partners, LTD. | 0 | 15,821 | +15,821 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 305,972 | 320,972 | +15,000 | 1.64 | 1.57 | -0.06 | buy |
| Triumph Capital Management | 900 | 15,135 | +14,235 | 0.01 | 0.07 | +0.07 | buy |
| NAVELLIER & ASSOCIATES INC | 0 | 13,753 | +13,753 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 172,066 | 183,024 | +10,958 | 0.02 | 0.02 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 32,512 | 43,234 | +10,722 | 0.01 | 0.01 | +0.00 | buy |
| Amundi | 0 | 9,091 | +9,091 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 179,420 | 188,220 | +8,800 | 0.14 | 0.12 | -0.02 | buy |
| LPL Financial LLC | 111,874 | 119,381 | +7,507 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 11,317 | 18,434 | +7,117 | 0.04 | 0.05 | +0.02 | buy |
| Handelsbanken Fonder AB | 34,300 | 41,300 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 7,275 | 14,033 | +6,758 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 106,488 | 112,954 | +6,466 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 6,812 | 13,274 | +6,462 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 25,303 | 31,597 | +6,294 | 0.02 | 0.01 | -0.01 | buy |
| Inspire Investing, LLC | 15,836 | 21,947 | +6,111 | 0.04 | 0.05 | +0.01 | buy |
| Merit Financial Group, LLC | 13,017 | 18,852 | +5,835 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 17,184 | 23,007 | +5,823 | 0.01 | 0.02 | +0.00 | buy |
| Entropy Technologies, LP | 12,144 | 17,964 | +5,820 | 0.02 | 0.02 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 23,549 | 29,092 | +5,543 | 0.19 | 0.19 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 231,734 | 237,171 | +5,437 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 212,800 | 218,200 | +5,400 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 37,059 | 42,131 | +5,072 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 144,949 | 149,867 | +4,918 | 0.00 | 0.00 | -0.00 | buy |
| Vontobel Holding Ltd. | 30,004 | 34,610 | +4,606 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 35,229 | 39,826 | +4,597 | 0.00 | 0.00 | -0.00 | buy |
| Freestone Grove Partners LP | 0 | 4,543 | +4,543 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 13,597 | 17,597 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 98,826 | 101,674 | +2,848 | 0.00 | 0.00 | -0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 141,271 | 143,934 | +2,663 | 0.63 | 0.54 | -0.09 | buy |
| Advisors Asset Management, Inc. | 76,598 | 79,116 | +2,518 | 0.04 | 0.03 | -0.01 | buy |
| Creative Planning | 27,166 | 29,651 | +2,485 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 26,531 | 28,908 | +2,377 | 0.00 | 0.00 | -0.00 | buy |
| FISHMAN JAY A LTD/MI | 564,650 | 566,730 | +2,080 | 1.35 | 1.19 | -0.16 | buy |
| China Universal Asset Management Co., Ltd. | 19,960 | 22,011 | +2,051 | 0.04 | 0.04 | -0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 116,360 | 118,223 | +1,863 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1,689 | +1,689 | 0.00 | 0.01 | +0.01 | buy |
| XPONANCE, INC. | 9,398 | 11,085 | +1,687 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 99,247 | 100,902 | +1,655 | 0.01 | 0.01 | -0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 49,262 | 50,863 | +1,601 | 0.08 | 0.08 | -0.00 | buy |
| KBC Group NV | 3,055 | 4,376 | +1,321 | 0.00 | 0.00 | +0.00 | buy |