| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 7,510,000 | 9,816,672 | +2,306,672 | 2.20 | 2.39 | +0.19 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,877,297 | 10,004,492 | +2,127,195 | 2.90 | 3.42 | +0.52 | buy |
| ExodusPoint Capital Management, LP | 222,222 | 1,113,582 | +891,360 | 0.03 | 0.12 | 0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 750,000 | 1,558,500 | +808,500 | 0.13 | 0.35 | +0.22 | buy |
| Tejara Capital Ltd | 940,487 | 1,343,609 | +403,122 | 3.45 | 4.55 | +1.10 | buy |
| Cormorant Asset Management, LP | 2,125,000 | 2,525,000 | +400,000 | 0.92 | 1.36 | +0.43 | buy |
| FISHMAN JAY A LTD/MI | 224,300 | 14,034 | +210,266 | 0.25 | 0.34 | 0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 723,325 | 572,615 | +150,710 | 0.01 | 0.01 | 0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 484,081 | 634,441 | +150,360 | 0.01 | 0.01 | 0.00 | buy |
| FISHMAN JAY A LTD/MI | 224,300 | 346,600 | +122,300 | 0.25 | 0.34 | +0.09 | buy |
| PROFUND ADVISORS LLC | 126,283 | 48,190 | +78,093 | 0.05 | 0.02 | 0.00 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,028,008 | 2,041,108 | +13,100 | 12.92 | 14.59 | +1.68 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 148,433 | 135,948 | +12,485 | 0.01 | 0.00 | 0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 21,250 | 27,612 | +6,362 | 0.04 | 0.05 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 48,997 | 48,586 | -411 | 0.03 | 0.02 | -0.00 | sell |
| PDT Partners, LLC | 320,226 | 319,715 | -511 | 0.30 | 0.28 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 4,254 | 1,555 | -2,699 | 0.01 | 0.00 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 18,614 | 13,601 | -5,013 | 0.02 | 0.02 | -0.01 | sell |
| Polar Capital Holdings Plc | 6,885,922 | 6,879,072 | -6,850 | 0.36 | 0.38 | +0.02 | sell |
| E Fund Management Co., Ltd. | 38,866 | 15,759 | -23,107 | 0.02 | 0.01 | -0.02 | sell |
| Two Seas Capital LP | 809,332 | 762,190 | -47,142 | 1.57 | 1.16 | -0.41 | sell |
| GW&K Investment Management, LLC | 1,721,253 | 1,667,979 | -53,274 | 0.15 | 0.14 | -0.01 | sell |
| Ikarian Capital, LLC | 589,642 | 489,642 | -100,000 | 0.64 | 0.79 | +0.15 | sell |
| J. Goldman & Co LP | 1,435,318 | 1,311,549 | -123,769 | 0.46 | 0.35 | -0.11 | sell |
| AMI ASSET MANAGEMENT CORP | 345,239 | 164,194 | -181,045 | 0.17 | 0.08 | -0.09 | sell |
| Sio Capital Management, LLC | 635,969 | 159,626 | -476,343 | 1.88 | 0.40 | -1.47 | sell |
| Rafferty Asset Management, LLC | 822,461 | 259,478 | -562,983 | 0.03 | 0.01 | -0.02 | sell |
| JENNISON ASSOCIATES LLC | 12,176,315 | 11,571,694 | -604,621 | 0.08 | 0.07 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 4,234,951 | 3,616,532 | -618,419 | 0.52 | 0.42 | -0.10 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,011,687 | 1,030,703 | -980,984 | 1.60 | 1.05 | -0.55 | sell |
| STEMPOINT CAPITAL LP | 2,205,899 | 965,392 | -1,240,507 | 5.84 | 2.64 | -3.20 | sell |