| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 7,510,000 | 9,816,672 | +2,306,672 | 2.20 | 2.41 | +0.21 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,877,297 | 10,004,492 | +2,127,195 | 3.29 | 3.80 | +0.50 | buy |
| Candriam S.C.A. | 0 | 1,307,481 | +1,307,481 | 0.00 | 0.07 | +0.07 | buy |
| CITADEL ADVISORS LLC | 1,914,270 | 2,932,647 | +1,018,377 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 5,166,417 | 6,144,290 | +977,873 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 222,222 | 1,113,582 | +891,360 | 0.03 | 0.11 | +0.09 | buy |
| Eversept Partners, LP | 0 | 837,847 | +837,847 | 0.00 | 0.60 | +0.60 | buy |
| PERCEPTIVE ADVISORS LLC | 750,000 | 1,558,500 | +808,500 | 0.13 | 0.35 | +0.22 | buy |
| D. E. Shaw & Co., Inc. | 216,866 | 1,007,384 | +790,518 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,971,433 | 2,421,270 | +449,837 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 940,487 | 1,343,609 | +403,122 | 3.45 | 4.55 | +1.10 | buy |
| Cormorant Asset Management, LP | 2,125,000 | 2,525,000 | +400,000 | 0.93 | 1.37 | +0.44 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 359,997 | +359,997 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 362,869 | 667,259 | +304,390 | 0.07 | 0.09 | +0.02 | buy |
| JPMORGAN CHASE & CO | 1,000,206 | 1,285,078 | +284,872 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 273,779 | +273,779 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 31,099 | 257,357 | +226,258 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 203,600 | +203,600 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 18,135 | 221,697 | +203,562 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 200,000 | +200,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,040,946 | 1,231,700 | +190,754 | 0.01 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 175,909 | +175,909 | 0.00 | 0.01 | +0.01 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 163,561 | +163,561 | 0.00 | 0.28 | +0.28 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 160,028 | +160,028 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 330,900 | 488,600 | +157,700 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 484,081 | 634,441 | +150,360 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 379,051 | 512,696 | +133,645 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 224,300 | 346,600 | +122,300 | 0.25 | 0.34 | +0.09 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 101,289 | +101,289 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 750,724 | 851,324 | +100,600 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 8,316 | 104,391 | +96,075 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,956 | 101,302 | +93,346 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 87,830 | +87,830 | 0.00 | 0.05 | +0.05 | buy |
| Jump Financial, LLC | 67,598 | 151,385 | +83,787 | 0.02 | 0.03 | +0.01 | buy |
| SG Americas Securities, LLC | 15,709 | 99,161 | +83,452 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 310,124 | 390,202 | +80,078 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 872,344 | 937,594 | +65,250 | 0.00 | 0.00 | -0.00 | buy |
| Capital Impact Advisors, LLC | 0 | 65,147 | +65,147 | 0.00 | 1.71 | +1.71 | buy |
| Close Asset Management Ltd | 0 | 64,774 | +64,774 | 0.00 | 0.02 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 63,093 | +63,093 | 0.00 | 0.05 | +0.05 | buy |
| Legato Capital Management LLC | 0 | 56,208 | +56,208 | 0.00 | 0.07 | +0.07 | buy |
| Graham Capital Management, L.P. | 13,466 | 66,165 | +52,699 | 0.00 | 0.02 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 52,600 | +52,600 | 0.00 | 0.00 | +0.00 | buy |
| Alpha DNA Investment Management LLC | 0 | 52,244 | +52,244 | 0.00 | 0.28 | +0.28 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 45,019 | +45,019 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 125,333 | 167,289 | +41,956 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 37,730 | +37,730 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 74,700 | 111,160 | +36,460 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 28,968 | +28,968 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 28,839 | +28,839 | 0.00 | 0.05 | +0.05 | buy |
| Corton Capital Inc. | 0 | 27,899 | +27,899 | 0.00 | 0.14 | +0.14 | buy |
| Aquatic Capital Management LLC | 0 | 26,500 | +26,500 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 26,400 | +26,400 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 10,673 | 36,466 | +25,793 | 0.01 | 0.03 | +0.01 | buy |
| Teza Capital Management LLC | 0 | 22,874 | +22,874 | 0.00 | 0.03 | +0.03 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 22,727 | +22,727 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 18,762 | +18,762 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 18,557 | +18,557 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 43,801 | 61,658 | +17,857 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 17,500 | +17,500 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,388 | 18,920 | +16,532 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 16,174 | +16,174 | 0.00 | 0.00 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,028,008 | 2,041,108 | +13,100 | 12.92 | 14.59 | +1.68 | buy |
| ROYAL BANK OF CANADA | 0 | 12,653 | +12,653 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 12,426 | +12,426 | 0.00 | 0.06 | +0.06 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,695 | 43,667 | +11,972 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 11,772 | +11,772 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 47,753 | 58,902 | +11,149 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 10,415 | +10,415 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 9,692 | +9,692 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,786 | 40,323 | +9,537 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,872,605 | 1,882,025 | +9,420 | 0.01 | 0.01 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 26,156 | 35,414 | +9,258 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 27,758 | 36,565 | +8,807 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 0 | 8,233 | +8,233 | 0.00 | 0.00 | +0.00 | buy |
| Castleview Partners, LLC | 0 | 8,113 | +8,113 | 0.00 | 0.04 | +0.04 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 13,787 | 20,547 | +6,760 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 6,572 | +6,572 | 0.00 | 0.03 | +0.03 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 21,250 | 27,612 | +6,362 | 0.04 | 0.05 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 46,547 | 52,226 | +5,679 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 60 | 4,104 | +4,044 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANZ SE | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 98,505 | 102,113 | +3,608 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 748,945 | 751,850 | +2,905 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,871 | 10,408 | +2,537 | 0.00 | 0.00 | +0.00 | buy |
| Coppell Advisory Solutions LLC | 0 | 2,319 | +2,319 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 21 | 1,003 | +982 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 125 | 1,068 | +943 | 0.00 | 0.00 | +0.00 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 0 | 875 | +875 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 806,524 | 807,334 | +810 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 10 | 769 | +759 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 539 | +539 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 398 | +398 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 360 | +360 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 3,544 | 3,793 | +249 | 0.01 | 0.01 | -0.00 | buy |
| Daiwa Securities Group Inc. | 245 | 439 | +194 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 11,120 | 11,170 | +50 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 60 | +45 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,048 | 1,052 | +4 | 0.00 | 0.00 | -0.00 | buy |