| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 8,785,284 | 9,874,511 | +1,089,227 | 6.28 | 5.54 | -0.74 | buy |
| J. Goldman & Co LP | 180,521 | 860,260 | +679,739 | 0.07 | 0.29 | +0.22 | buy |
| D. E. Shaw & Co., Inc. | 1,989,508 | 2,163,001 | +173,493 | 0.04 | 0.03 | 0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 60,200 | 200,253 | +140,053 | 0.05 | 0.12 | +0.07 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,422,978 | 11,535,582 | +112,604 | 6.63 | 4.88 | -1.75 | buy |
| ROYCE & ASSOCIATES LP | 267,612 | 374,540 | +106,928 | 0.05 | 0.05 | +0.01 | buy |
| Aberdeen Group plc | 587,540 | 675,034 | +87,494 | 0.02 | 0.02 | -0.00 | buy |
| MYDA Advisors LLC | 290,000 | 370,000 | +80,000 | 0.79 | 0.91 | +0.12 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,652,492 | 1,724,307 | +71,815 | 0.02 | 0.01 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,096,051 | 4,155,763 | +59,712 | 0.84 | 0.62 | -0.22 | buy |
| Tejara Capital Ltd | 846,221 | 873,381 | +27,160 | 6.52 | 5.68 | -0.85 | buy |
| FISHMAN JAY A LTD/MI | 533,150 | 556,150 | +23,000 | 0.91 | 0.75 | -0.16 | buy |
| Jackson Creek Investment Advisors LLC | 113,536 | 135,871 | +22,335 | 0.56 | 0.51 | -0.05 | buy |
| ALGERT GLOBAL LLC | 120,880 | 98,755 | +22,125 | 0.05 | 0.03 | 0.00 | sell |
| Privium Fund Management B.V. | 325,709 | 344,472 | +18,763 | 1.33 | 1.02 | -0.31 | buy |
| Advisors Asset Management, Inc. | 28,187 | 44,295 | +16,108 | 0.01 | 0.01 | 0.00 | buy |
| Diametric Capital, LP | 24,344 | 38,858 | +14,514 | 0.45 | 0.29 | -0.16 | buy |
| LAZARD ASSET MANAGEMENT LLC | 374,083 | 386,011 | +11,928 | 0.01 | 0.01 | 0.00 | buy |
| Inspire Investing, LLC | 21,570 | 28,772 | +7,202 | 0.04 | 0.04 | +0.00 | buy |
| Quarry LP | 6,500 | 12,590 | +6,090 | 0.03 | 0.04 | 0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 593,195 | 598,900 | +5,705 | 0.01 | 0.01 | 0.00 | buy |
| GK Wealth Management LLC | 14,667 | 18,801 | +4,134 | 0.29 | 0.26 | -0.02 | buy |
| LVW Advisors, LLC | 14,466 | 17,561 | +3,095 | 0.03 | 0.03 | -0.00 | buy |
| E Fund Management Co., Ltd. | 14,987 | 17,184 | +2,197 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 23,797 | 23,941 | +144 | 0.03 | 0.03 | -0.00 | buy |
| Phocas Financial Corp. | 103,999 | 104,014 | +15 | 0.25 | 0.21 | -0.04 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 16,200 | 15,700 | -500 | 0.00 | 0.00 | -0.00 | sell |
| SYON CAPITAL LLC | 10,762 | 10,130 | -632 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 33,738 | 32,669 | -1,069 | 0.02 | 0.02 | -0.01 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 190,638 | 189,511 | -1,127 | 0.62 | 0.48 | -0.14 | sell |
| Rafferty Asset Management, LLC | 160,367 | 154,351 | -6,016 | 0.01 | 0.01 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 13,401 | 6,965 | -6,436 | 0.06 | 0.03 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,092,735 | 1,085,954 | -6,781 | 0.16 | 0.12 | -0.04 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 23,085 | 15,203 | -7,882 | 0.03 | 0.02 | -0.01 | sell |
| Bellevue Group AG | 35,700 | 24,008 | -11,692 | 0.01 | 0.01 | -0.01 | sell |
| Silverleafe Capital Partners, LLC | 26,208 | 14,500 | -11,708 | 0.14 | 0.07 | -0.07 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 29,967 | 11,267 | -18,700 | 0.07 | 0.03 | -0.05 | sell |
| AMI ASSET MANAGEMENT CORP | 208,721 | 113,882 | -94,839 | 0.19 | 0.09 | -0.10 | sell |
| PDT Partners, LLC | 317,465 | 190,983 | -126,482 | 0.35 | 0.15 | -0.20 | sell |
| GW&K Investment Management, LLC | 1,512,211 | 1,378,432 | -133,779 | 0.22 | 0.17 | -0.05 | sell |
| Woodline Partners LP | 410,000 | 205,510 | -204,490 | 0.04 | 0.02 | -0.03 | sell |
| Rubric Capital Management LP | 10,966,672 | 10,749,457 | -217,215 | 3.07 | 2.28 | -0.80 | sell |
| STEMPOINT CAPITAL LP | 440,073 | 205,672 | -234,401 | 2.20 | 0.93 | -1.27 | sell |
| Candriam S.C.A. | 1,035,576 | 790,435 | -245,141 | 0.10 | 0.06 | -0.04 | sell |
| Simplify Asset Management Inc. | 660,557 | 409,432 | -251,125 | 0.48 | 0.35 | -0.13 | sell |
| JENNISON ASSOCIATES LLC | 11,360,875 | 11,109,405 | -251,470 | 0.12 | 0.09 | -0.03 | sell |
| Cormorant Asset Management, LP | 1,350,000 | 1,000,000 | -350,000 | 1.59 | 1.04 | -0.54 | sell |
| Polar Capital Holdings Plc | 6,706,475 | 5,006,475 | -1,700,000 | 0.64 | 0.37 | -0.27 | sell |