| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 52,600 | 2,263,960 | +2,211,360 | 0.00 | 0.02 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 8,785,284 | 9,874,511 | +1,089,227 | 6.28 | 5.54 | -0.74 | buy |
| PFM Health Sciences, LP | 0 | 923,375 | +923,375 | 0.00 | 1.12 | +1.12 | buy |
| GOLDMAN SACHS GROUP INC | 1,103,413 | 1,890,246 | +786,833 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 514,951 | 1,202,513 | +687,562 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 180,521 | 860,260 | +679,739 | 0.10 | 0.38 | +0.28 | buy |
| Point72 Asset Management, L.P. | 830,478 | 1,485,425 | +654,947 | 0.04 | 0.05 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 18,466 | 520,284 | +501,818 | 0.00 | 0.06 | +0.05 | buy |
| MORGAN STANLEY | 3,838,541 | 4,314,530 | +475,989 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 473,625 | 910,841 | +437,216 | 0.01 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 412,738 | +412,738 | 0.00 | 0.05 | +0.05 | buy |
| Qube Research & Technologies Ltd | 192,219 | 577,493 | +385,274 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 0 | 268,000 | +268,000 | 0.00 | 0.75 | +0.75 | buy |
| ROYAL BANK OF CANADA | 0 | 263,809 | +263,809 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 6,818,078 | 7,049,099 | +231,021 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 194,772 | 394,041 | +199,269 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,989,508 | 2,163,001 | +173,493 | 0.04 | 0.03 | -0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 60,200 | 200,253 | +140,053 | 0.05 | 0.12 | +0.07 | buy |
| AQR CAPITAL MANAGEMENT LLC | 248,196 | 375,233 | +127,037 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 279,047 | 404,736 | +125,689 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,422,978 | 11,535,582 | +112,604 | 7.23 | 6.09 | -1.14 | buy |
| ROYCE & ASSOCIATES LP | 267,612 | 374,540 | +106,928 | 0.05 | 0.05 | +0.01 | buy |
| Squarepoint Ops LLC | 62,327 | 167,814 | +105,487 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 860,768 | 965,066 | +104,298 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 0 | 95,000 | +95,000 | 0.00 | 0.07 | +0.07 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,624 | 260,987 | +92,363 | 0.00 | 0.01 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 90,191 | +90,191 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 587,540 | 675,034 | +87,494 | 0.02 | 0.02 | -0.00 | buy |
| MYDA Advisors LLC | 290,000 | 370,000 | +80,000 | 1.61 | 1.46 | -0.15 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,652,492 | 1,724,307 | +71,815 | 0.02 | 0.01 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,096,051 | 4,155,763 | +59,712 | 0.84 | 0.62 | -0.22 | buy |
| CITIGROUP INC | 301,552 | 359,422 | +57,870 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 56,100 | +56,100 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,474,203 | 4,526,937 | +52,734 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,546,947 | 2,582,567 | +35,620 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 37,617 | 71,620 | +34,003 | 0.02 | 0.03 | +0.01 | buy |
| Engineers Gate Manager LP | 66,123 | 97,605 | +31,482 | 0.02 | 0.02 | -0.00 | buy |
| Triumph Capital Management | 0 | 29,244 | +29,244 | 0.00 | 0.12 | +0.12 | buy |
| DnB Asset Management AS | 0 | 28,171 | +28,171 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 846,221 | 873,381 | +27,160 | 6.52 | 5.68 | -0.85 | buy |
| Trek Financial, LLC | 0 | 24,970 | +24,970 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 719 | 24,929 | +24,210 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 533,150 | 556,150 | +23,000 | 0.91 | 0.75 | -0.16 | buy |
| Jackson Creek Investment Advisors LLC | 113,536 | 135,871 | +22,335 | 0.56 | 0.51 | -0.05 | buy |
| Mach-1 Financial Group, LLC | 0 | 22,254 | +22,254 | 0.00 | 0.09 | +0.09 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,607 | 31,864 | +19,257 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 325,709 | 344,472 | +18,763 | 1.33 | 1.02 | -0.31 | buy |
| UBS Group AG | 2,920,008 | 2,937,939 | +17,931 | 0.01 | 0.01 | -0.00 | buy |
| Dauntless Investment Group, LLC | 0 | 16,951 | +16,951 | 0.00 | 1.12 | +1.12 | buy |
| Corton Capital Inc. | 0 | 16,943 | +16,943 | 0.00 | 0.28 | +0.28 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 69,694 | 86,282 | +16,588 | 0.01 | 0.01 | +0.00 | buy |
| Advisors Asset Management, Inc. | 28,187 | 44,295 | +16,108 | 0.01 | 0.01 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 15,666 | +15,666 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 24,344 | 38,858 | +14,514 | 0.45 | 0.29 | -0.16 | buy |
| Bayesian Capital Management, LP | 0 | 13,900 | +13,900 | 0.00 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 1,988,389 | 2,001,439 | +13,050 | 0.06 | 0.05 | -0.01 | buy |
| CANADA LIFE ASSURANCE Co | 12,816 | 25,829 | +13,013 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 12,700 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 374,083 | 386,011 | +11,928 | 0.01 | 0.01 | -0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 11,558 | +11,558 | 0.00 | 0.05 | +0.05 | buy |
| Kestra Advisory Services, LLC | 0 | 11,550 | +11,550 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 0 | 11,312 | +11,312 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 240 | 11,190 | +10,950 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 116,476 | 127,122 | +10,646 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 10,343 | +10,343 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 10,316 | +10,316 | 0.00 | 0.00 | +0.00 | buy |
| Atlas Wealth LLC | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| Tower Research Capital LLC (TRC) | 3,279 | 12,414 | +9,135 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 21,570 | 28,772 | +7,202 | 0.04 | 0.04 | +0.00 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 14,158 | 21,282 | +7,124 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 77,940 | 84,047 | +6,107 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 6,500 | 12,590 | +6,090 | 0.03 | 0.04 | +0.02 | buy |
| AlphaQuest LLC | 5,927 | 11,921 | +5,994 | 0.01 | 0.02 | +0.01 | buy |
| LPL Financial LLC | 115,757 | 121,617 | +5,860 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 593,195 | 598,900 | +5,705 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 543,382 | 548,789 | +5,407 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 300,031 | 305,258 | +5,227 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 181,074 | 186,099 | +5,025 | 0.00 | 0.00 | -0.00 | buy |
| GK Wealth Management LLC | 14,667 | 18,801 | +4,134 | 0.29 | 0.26 | -0.02 | buy |
| Legal & General Group Plc | 107,578 | 111,603 | +4,025 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 40,618 | 43,934 | +3,316 | 0.02 | 0.01 | -0.01 | buy |
| KLP KAPITALFORVALTNING AS | 18,500 | 21,800 | +3,300 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,419 | 11,653 | +3,234 | 0.00 | 0.00 | +0.00 | buy |
| LVW Advisors, LLC | 14,466 | 17,561 | +3,095 | 0.03 | 0.03 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 18,457 | 21,094 | +2,637 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 14,987 | 17,184 | +2,197 | 0.01 | 0.01 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,071 | +2,071 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 21,324 | 23,271 | +1,947 | 0.15 | 0.11 | -0.05 | buy |
| Creative Planning | 18,098 | 19,575 | +1,477 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 1,154 | +1,154 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 501 | 1,642 | +1,141 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 1,046 | +1,046 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 30,159 | 31,117 | +958 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 0 | 916 | +916 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 8,008 | 8,828 | +820 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 63,950 | 64,706 | +756 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 1,127 | 1,789 | +662 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,010 | 4,605 | +595 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 52 | 619 | +567 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 508 | +508 | 0.00 | 0.00 | +0.00 | buy |