| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,422,978 | 11,535,582 | +112,604 | 7.23 | 6.09 | -1.14 | buy |
| JENNISON ASSOCIATES LLC | 11,360,875 | 11,109,405 | -251,470 | 0.12 | 0.09 | -0.03 | sell |
| Rubric Capital Management LP | 10,966,672 | 10,749,457 | -217,215 | 3.07 | 2.42 | -0.65 | sell |
| Frazier Life Sciences Management, L.P. | 8,785,284 | 9,874,511 | +1,089,227 | 6.28 | 5.54 | -0.74 | buy |
| BlackRock, Inc. | 8,892,337 | 8,532,761 | -359,576 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 6,818,078 | 7,049,099 | +231,021 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 6,706,475 | 5,006,475 | -1,700,000 | 0.64 | 0.37 | -0.27 | sell |
| STATE STREET CORP | 4,474,203 | 4,526,937 | +52,734 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 3,838,541 | 4,314,530 | +475,989 | 0.00 | 0.00 | -0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,096,051 | 4,155,763 | +59,712 | 0.84 | 0.62 | -0.22 | buy |
| UBS Group AG | 2,920,008 | 2,937,939 | +17,931 | 0.01 | 0.01 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 2,761,767 | 2,732,777 | -28,990 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,546,947 | 2,582,567 | +35,620 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 52,600 | 2,263,960 | +2,211,360 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 1,989,508 | 2,163,001 | +173,493 | 0.04 | 0.03 | -0.01 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,120,508 | 2,120,508 | 0 | 26.84 | 18.43 | -8.41 | hold |
| Ensign Peak Advisors, Inc | 1,988,389 | 2,001,439 | +13,050 | 0.06 | 0.05 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,103,413 | 1,890,246 | +786,833 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,652,492 | 1,724,307 | +71,815 | 0.02 | 0.01 | -0.00 | buy |
| Point72 Asset Management, L.P. | 830,478 | 1,485,425 | +654,947 | 0.04 | 0.05 | +0.01 | buy |
| GW&K Investment Management, LLC | 1,512,211 | 1,378,432 | -133,779 | 0.22 | 0.17 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 514,951 | 1,202,513 | +687,562 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,092,735 | 1,085,954 | -6,781 | 0.16 | 0.12 | -0.04 | sell |
| Cormorant Asset Management, LP | 1,350,000 | 1,000,000 | -350,000 | 1.60 | 1.04 | -0.55 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 860,768 | 965,066 | +104,298 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 976,070 | 928,688 | -47,382 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 0 | 923,375 | +923,375 | 0.00 | 1.12 | +1.12 | buy |
| MILLENNIUM MANAGEMENT LLC | 473,625 | 910,841 | +437,216 | 0.01 | 0.01 | +0.00 | buy |
| Tejara Capital Ltd | 846,221 | 873,381 | +27,160 | 6.52 | 5.68 | -0.85 | buy |
| J. Goldman & Co LP | 180,521 | 860,260 | +679,739 | 0.10 | 0.38 | +0.28 | buy |
| Candriam S.C.A. | 1,035,576 | 790,435 | -245,141 | 0.10 | 0.06 | -0.04 | sell |
| Nuveen, LLC | 815,816 | 765,579 | -50,237 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 737,555 | 737,369 | -186 | 0.02 | 0.02 | -0.01 | sell |
| Aberdeen Group plc | 587,540 | 675,034 | +87,494 | 0.02 | 0.02 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 593,195 | 598,900 | +5,705 | 0.01 | 0.01 | -0.00 | buy |
| Qube Research & Technologies Ltd | 192,219 | 577,493 | +385,274 | 0.00 | 0.01 | +0.01 | buy |
| FISHMAN JAY A LTD/MI | 533,150 | 556,150 | +23,000 | 0.91 | 0.75 | -0.16 | buy |
| JPMORGAN CHASE & CO | 543,382 | 548,789 | +5,407 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 18,466 | 520,284 | +501,818 | 0.00 | 0.06 | +0.05 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 412,738 | +412,738 | 0.00 | 0.05 | +0.05 | buy |
| Simplify Asset Management Inc. | 660,557 | 409,432 | -251,125 | 0.48 | 0.35 | -0.13 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 279,047 | 404,736 | +125,689 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 194,772 | 394,041 | +199,269 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 374,083 | 386,011 | +11,928 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 248,196 | 375,233 | +127,037 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 267,612 | 374,540 | +106,928 | 0.05 | 0.05 | +0.01 | buy |
| MYDA Advisors LLC | 290,000 | 370,000 | +80,000 | 1.61 | 1.46 | -0.15 | buy |
| DEUTSCHE BANK AG\ | 381,355 | 367,415 | -13,940 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 301,552 | 359,422 | +57,870 | 0.00 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 325,709 | 344,472 | +18,763 | 1.33 | 1.02 | -0.31 | buy |
| FIRST TRUST ADVISORS LP | 440,185 | 341,521 | -98,664 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 300,031 | 305,258 | +5,227 | 0.00 | 0.00 | -0.00 | buy |
| Avidity Partners Management LP | 0 | 268,000 | +268,000 | 0.00 | 0.75 | +0.75 | buy |
| ROYAL BANK OF CANADA | 0 | 263,809 | +263,809 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,624 | 260,987 | +92,363 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 440,073 | 205,672 | -234,401 | 2.20 | 0.93 | -1.27 | sell |
| Woodline Partners LP | 410,000 | 205,510 | -204,490 | 0.04 | 0.02 | -0.03 | sell |
| Swiss National Bank | 204,000 | 204,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| READYSTATE ASSET MANAGEMENT LP | 60,200 | 200,253 | +140,053 | 0.05 | 0.12 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 198,359 | 196,300 | -2,059 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 317,465 | 190,983 | -126,482 | 0.35 | 0.15 | -0.20 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 190,638 | 189,511 | -1,127 | 0.62 | 0.48 | -0.14 | sell |
| RHUMBLINE ADVISERS | 181,074 | 186,099 | +5,025 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 679,320 | 174,820 | -504,500 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 62,327 | 167,814 | +105,487 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 160,367 | 154,351 | -6,016 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 162,449 | 150,730 | -11,719 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 310,075 | 145,493 | -164,582 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 140,000 | 140,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jackson Creek Investment Advisors LLC | 113,536 | 135,871 | +22,335 | 0.56 | 0.51 | -0.05 | buy |
| JANE STREET GROUP, LLC | 116,476 | 127,122 | +10,646 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 115,757 | 121,617 | +5,860 | 0.00 | 0.00 | -0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 208,721 | 113,882 | -94,839 | 0.19 | 0.09 | -0.10 | sell |
| ALLIANCEBERNSTEIN L.P. | 113,360 | 113,360 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 107,578 | 111,603 | +4,025 | 0.00 | 0.00 | -0.00 | buy |
| Phocas Financial Corp. | 103,999 | 104,014 | +15 | 0.25 | 0.21 | -0.04 | buy |
| WESBANCO BANK INC | 102,700 | 102,700 | 0 | 0.06 | 0.04 | -0.01 | hold |
| Invesco Ltd. | 1,328,954 | 99,703 | -1,229,251 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 113,379 | 99,044 | -14,335 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 120,880 | 98,755 | -22,125 | 0.05 | 0.03 | -0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 97,682 | 97,682 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 66,123 | 97,605 | +31,482 | 0.02 | 0.02 | -0.00 | buy |
| Vestal Point Capital, LP | 0 | 95,000 | +95,000 | 0.00 | 0.07 | +0.07 | buy |
| STIFEL FINANCIAL CORP | 0 | 90,191 | +90,191 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 152,861 | 89,879 | -62,982 | 0.01 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 69,694 | 86,282 | +16,588 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 77,940 | 84,047 | +6,107 | 0.00 | 0.00 | -0.00 | buy |
| Erste Asset Management GmbH | 73,100 | 73,100 | 0 | 0.01 | 0.01 | -0.01 | hold |
| TWO SIGMA INVESTMENTS, LP | 151,569 | 71,681 | -79,888 | 0.01 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 37,617 | 71,620 | +34,003 | 0.02 | 0.03 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,417 | 66,236 | -5,181 | 0.00 | 0.00 | -0.00 | sell |
| Close Asset Management Ltd | 64,774 | 64,774 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Focus Partners Wealth | 63,950 | 64,706 | +756 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 64,485 | 64,485 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 58,093 | 57,948 | -145 | 0.00 | 0.00 | -0.00 | sell |
| Legato Capital Management LLC | 56,717 | 56,717 | 0 | 0.12 | 0.09 | -0.02 | hold |
| Verition Fund Management LLC | 0 | 56,100 | +56,100 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 58,046 | 53,623 | -4,423 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 48,670 | 48,670 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KEYBANK NATIONAL ASSOCIATION/OH | 46,515 | 46,515 | 0 | 0.00 | 0.00 | -0.00 | hold |