| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,327,000 | 12,437,000 | +110,000 | 7.88 | 6.85 | -1.02 | buy |
| BlackRock, Inc. | 9,200,411 | 10,545,466 | +1,345,055 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 9,874,511 | 9,874,511 | 0 | 5.99 | 5.64 | -0.35 | hold |
| Rubric Capital Management LP | 8,271,577 | 8,271,577 | 0 | 2.39 | 1.99 | -0.40 | hold |
| Polar Capital Holdings Plc | 5,666,940 | 6,606,945 | +940,005 | 0.58 | 0.49 | -0.09 | buy |
| STATE STREET CORP | 6,296,197 | 5,822,840 | -473,357 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 4,218,931 | 4,451,014 | +232,083 | 0.01 | 0.01 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 4,980,770 | 4,219,058 | -761,712 | 0.08 | 0.07 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 2,496,222 | 3,949,609 | +1,453,387 | 0.05 | 0.06 | +0.02 | buy |
| UBS Group AG | 3,329,224 | 3,333,015 | +3,791 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,221,289 | 2,987,431 | +766,142 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,045,306 | 2,982,446 | -62,860 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 2,042,000 | +2,042,000 | 0.00 | 1.01 | +1.01 | buy |
| FRANKLIN RESOURCES INC | 2,297,943 | 1,930,982 | -366,961 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,463,228 | 1,925,031 | +461,803 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,603,013 | 1,668,367 | +65,354 | 0.00 | 0.00 | -0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 1,365,941 | 1,372,941 | +7,000 | 0.95 | 0.74 | -0.21 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,304,010 | 1,313,211 | -2,990,799 | 1.22 | 0.36 | -0.86 | sell |
| GW&K Investment Management, LLC | 988,387 | 1,288,018 | +299,631 | 0.21 | 0.26 | +0.06 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,355,892 | 1,265,283 | -90,609 | 11.42 | 10.78 | -0.64 | sell |
| BAMCO INC /NY/ | 1,072,189 | 1,253,120 | +180,931 | 0.08 | 0.05 | -0.03 | buy |
| CITADEL ADVISORS LLC | 15,606 | 1,160,014 | +1,144,408 | 0.00 | 0.02 | +0.02 | buy |
| FEDERATED HERMES, INC. | 1,077,267 | 1,124,629 | +47,362 | 0.04 | 0.04 | +0.00 | buy |
| Perpetual Ltd | 909,546 | 1,109,657 | +200,111 | 0.33 | 0.42 | +0.09 | buy |
| Aberdeen Group plc | 645,066 | 1,098,411 | +453,345 | 0.02 | 0.04 | +0.02 | buy |
| NORTHERN TRUST CORP | 976,512 | 1,058,575 | +82,063 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,050,934 | +1,050,934 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,012,555 | 1,050,934 | +38,379 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 1,244,387 | 974,534 | -269,853 | 0.05 | 0.04 | -0.01 | sell |
| Candriam S.C.A. | 1,086,651 | 949,839 | -136,812 | 0.13 | 0.11 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,226,029 | 878,426 | -1,347,603 | 0.39 | 0.13 | -0.25 | sell |
| Nuveen, LLC | 902,134 | 834,261 | -67,873 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 503,856 | 811,752 | +307,896 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 234,307 | 663,877 | +429,570 | 0.00 | 0.01 | +0.01 | buy |
| FISHMAN JAY A LTD/MI | 566,730 | 595,005 | +28,275 | 1.19 | 1.24 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 49,333 | 564,072 | +514,739 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 812,146 | 547,278 | -264,868 | 0.01 | 0.01 | -0.01 | sell |
| Squarepoint Ops LLC | 1,103,490 | 537,747 | -565,743 | 0.06 | 0.03 | -0.03 | sell |
| Nearwater Capital Markets, Ltd | 607,300 | 486,700 | -120,600 | 0.34 | 0.22 | -0.12 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 366,000 | 466,000 | +100,000 | 0.01 | 0.02 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,431,778 | 446,866 | -1,984,912 | 0.06 | 0.01 | -0.05 | sell |
| Privium Fund Management B.V. | 320,972 | 399,367 | +78,395 | 1.57 | 1.92 | +0.35 | buy |
| NORGES BANK | 0 | 392,300 | +392,300 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 389,847 | 382,682 | -7,165 | 0.00 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 400,645 | 370,000 | -30,645 | 1.67 | 1.50 | -0.17 | sell |
| Point72 Asset Management, L.P. | 590,877 | 362,449 | -228,428 | 0.02 | 0.01 | -0.01 | sell |
| Qube Research & Technologies Ltd | 724,067 | 361,662 | -362,405 | 0.02 | 0.01 | -0.01 | sell |
| Longaeva Partners L.P. | 0 | 344,796 | +344,796 | 0.00 | 0.26 | +0.26 | buy |
| AQR CAPITAL MANAGEMENT LLC | 468,253 | 330,324 | -137,929 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 305,532 | 330,094 | +24,562 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 278,736 | 305,969 | +27,233 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 101,674 | 295,997 | +194,323 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 306,272 | 291,447 | -14,825 | 0.27 | 0.25 | -0.02 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 636,200 | 284,789 | -351,411 | 0.02 | 0.01 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 351,217 | 284,065 | -67,152 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 139,843 | 264,907 | +125,064 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 50,460 | 260,033 | +209,573 | 0.01 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 243,119 | +243,119 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 0 | 242,069 | +242,069 | 0.00 | 0.55 | +0.55 | buy |
| MYDA Advisors LLC | 240,000 | 240,000 | 0 | 1.33 | 1.53 | +0.20 | hold |
| Jump Financial, LLC | 49,567 | 235,471 | +185,904 | 0.02 | 0.06 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 237,171 | 231,186 | -5,985 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 100,902 | 230,905 | +130,003 | 0.01 | 0.01 | +0.01 | buy |
| Swiss National Bank | 218,200 | 224,000 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,179 | 219,815 | +107,636 | 0.00 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 217,255 | 202,515 | -14,740 | 0.03 | 0.03 | -0.00 | sell |
| Pictet Asset Management Holding SA | 138,112 | 200,275 | +62,163 | 0.00 | 0.01 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 175,870 | 199,683 | +23,813 | 0.09 | 0.11 | +0.02 | buy |
| Woodline Partners LP | 195,033 | 195,033 | 0 | 0.02 | 0.02 | -0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 168,826 | 183,662 | +14,836 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 450,000 | 175,000 | -275,000 | 0.53 | 0.24 | -0.30 | sell |
| RHUMBLINE ADVISERS | 161,131 | 170,542 | +9,411 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 163,732 | +163,732 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 448,207 | 157,778 | -290,429 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 540,511 | 157,429 | -383,082 | 0.05 | 0.02 | -0.03 | sell |
| PDT Partners, LLC | 155,075 | 155,075 | 0 | 0.22 | 0.21 | -0.00 | hold |
| Vontobel Holding Ltd. | 34,610 | 153,242 | +118,632 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 48,337 | 151,394 | +103,057 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 154,422 | 137,929 | -16,493 | 0.01 | 0.01 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 143,934 | 137,500 | -6,434 | 0.54 | 0.47 | -0.06 | sell |
| CASTLEARK MANAGEMENT LLC | 293,460 | 137,420 | -156,040 | 0.23 | 0.10 | -0.13 | sell |
| ALLIANCEBERNSTEIN L.P. | 118,223 | 136,393 | +18,170 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 576,580 | 135,355 | -441,225 | 0.90 | 0.19 | -0.70 | sell |
| LAZARD ASSET MANAGEMENT LLC | 154,566 | 133,146 | -21,420 | 0.01 | 0.01 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 131,914 | +131,914 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 128,317 | 126,258 | -2,059 | 0.00 | 0.00 | -0.00 | sell |
| 1492 Capital Management LLC | 118,156 | 116,211 | -1,945 | 1.06 | 0.90 | -0.16 | sell |
| SEI INVESTMENTS CO | 206,141 | 114,253 | -91,888 | 0.00 | 0.00 | -0.00 | sell |
| Tejara Capital Ltd | 166,191 | 113,084 | -53,107 | 1.29 | 1.22 | -0.07 | sell |
| LPL Financial LLC | 119,381 | 111,150 | -8,231 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 197,810 | 109,079 | -88,731 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 104,356 | 104,356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 84,877 | 100,808 | +15,931 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 413,792 | 98,945 | -314,847 | 1.87 | 0.45 | -1.42 | sell |
| JPMORGAN CHASE & CO | 112,954 | 97,966 | -14,988 | 0.00 | 0.00 | -0.00 | sell |
| Advisors Asset Management, Inc. | 79,116 | 95,934 | +16,818 | 0.03 | 0.04 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88,484 | 94,638 | +6,154 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 64,219 | 94,272 | +30,053 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 34,607 | 86,130 | +51,523 | 0.02 | 0.08 | +0.05 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 86,027 | +86,027 | 0.00 | 0.01 | +0.01 | buy |