| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 9,816,672 | 10,966,672 | +1,150,000 | 2.41 | 1.67 | -0.74 | buy |
| VANGUARD GROUP INC | 6,144,290 | 6,962,635 | +818,345 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 965,392 | 1,778,318 | +812,926 | 2.64 | 4.96 | +2.32 | buy |
| GOLDMAN SACHS GROUP INC | 807,334 | 1,589,882 | +782,548 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,007,384 | 1,745,024 | +737,640 | 0.01 | 0.02 | +0.01 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,004,492 | 10,721,511 | +717,019 | 3.80 | 3.58 | -0.22 | buy |
| MILLENNIUM MANAGEMENT LLC | 512,696 | 1,147,473 | +634,777 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 567,123 | 1,175,905 | +608,782 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 5,134,843 | 5,641,631 | +506,788 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 359,997 | 803,204 | +443,207 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 148,874 | 482,074 | +333,200 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 2,133,702 | 2,416,812 | +283,110 | 0.04 | 0.04 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 244,386 | +244,386 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,231,700 | 1,464,311 | +232,611 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 28,575 | 237,174 | +208,599 | 0.02 | 0.17 | +0.15 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 192,099 | +192,099 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 751,850 | 936,515 | +184,665 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 1,311,549 | 1,492,217 | +180,668 | 0.45 | 0.60 | +0.15 | buy |
| FEDERATED HERMES, INC. | 350,114 | 501,831 | +151,717 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 102,113 | 253,392 | +151,279 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 128,180 | +128,180 | 0.00 | 0.02 | +0.02 | buy |
| Candriam S.C.A. | 1,307,481 | 1,426,496 | +119,015 | 0.07 | 0.08 | +0.00 | buy |
| WESBANCO BANK INC | 0 | 102,700 | +102,700 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 2,932,647 | 3,031,073 | +98,426 | 0.03 | 0.03 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 92,019 | +92,019 | 0.00 | 0.02 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 11,571,694 | 11,663,497 | +91,803 | 0.07 | 0.07 | -0.00 | buy |
| Capula Management Ltd | 0 | 88,723 | +88,723 | 0.00 | 0.01 | +0.01 | buy |
| Stonepine Capital Management, LLC | 0 | 88,457 | +88,457 | 0.00 | 0.52 | +0.52 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,041,108 | 2,120,508 | +79,400 | 14.59 | 11.71 | -2.89 | buy |
| Squarepoint Ops LLC | 0 | 72,623 | +72,623 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 346,600 | 418,000 | +71,400 | 0.34 | 0.39 | +0.05 | buy |
| ALGERT GLOBAL LLC | 10,415 | 72,480 | +62,065 | 0.00 | 0.02 | +0.01 | buy |
| AMI ASSET MANAGEMENT CORP | 164,194 | 223,681 | +59,487 | 0.08 | 0.11 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,421,270 | 2,470,138 | +48,868 | 0.00 | 0.00 | -0.00 | buy |
| MYDA Advisors LLC | 75,000 | 120,000 | +45,000 | 0.21 | 0.32 | +0.11 | buy |
| Inspire Investing, LLC | 0 | 44,344 | +44,344 | 0.00 | 0.04 | +0.04 | buy |
| AlphaQuest LLC | 0 | 42,838 | +42,838 | 0.00 | 0.04 | +0.04 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 37,090 | +37,090 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 0 | 35,100 | +35,100 | 0.00 | 1.31 | +1.31 | buy |
| CITIGROUP INC | 54,599 | 89,622 | +35,023 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 136,335 | 171,219 | +34,884 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 17,500 | 39,500 | +22,000 | 0.00 | 0.01 | +0.00 | buy |
| Cerity Partners LLC | 0 | 21,102 | +21,102 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 20,964 | +20,964 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 12,426 | 32,907 | +20,481 | 0.06 | 0.15 | +0.09 | buy |
| Qube Research & Technologies Ltd | 0 | 20,432 | +20,432 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 0 | 19,200 | +19,200 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,444 | 69,369 | +18,925 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 259,478 | 276,818 | +17,340 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 14,938 | +14,938 | 0.00 | 0.01 | +0.01 | buy |
| ALTFEST L J & CO INC | 0 | 14,408 | +14,408 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 16,174 | 30,349 | +14,175 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 13,676 | +13,676 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 12,714 | +12,714 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 63,093 | 75,548 | +12,455 | 0.05 | 0.05 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,323 | 52,503 | +12,180 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 77,406 | 89,267 | +11,861 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,285,078 | 1,296,911 | +11,833 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 36,466 | 47,728 | +11,262 | 0.03 | 0.03 | +0.00 | buy |
| EntryPoint Capital, LLC | 6,572 | 17,774 | +11,202 | 0.03 | 0.09 | +0.07 | buy |
| CIBC Private Wealth Group LLC | 0 | 9,558 | +9,558 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 17,739 | 26,984 | +9,245 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,601 | 22,482 | +8,881 | 0.02 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 851,324 | 859,846 | +8,522 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,003 | 9,384 | +8,381 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,400 | 34,076 | +7,676 | 0.01 | 0.01 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 6,577 | +6,577 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 48,190 | 54,582 | +6,392 | 0.02 | 0.02 | +0.00 | buy |
| Polar Capital Holdings Plc | 6,879,072 | 6,884,372 | +5,300 | 0.38 | 0.31 | -0.07 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 101,289 | 106,267 | +4,978 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 104,391 | 107,976 | +3,585 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 22,727 | 26,129 | +3,402 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 273,779 | 276,691 | +2,912 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 2,669 | +2,669 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 15,759 | 17,785 | +2,026 | 0.01 | 0.01 | +0.00 | buy |
| CWM, LLC | 4,104 | 5,815 | +1,711 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,902 | 60,148 | +1,246 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,688 | 12,843 | +1,155 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 28,968 | 30,000 | +1,032 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 52,226 | 53,149 | +923 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 937,594 | 938,484 | +890 | 0.00 | 0.00 | -0.00 | buy |
| Parallax Volatility Advisers, L.P. | 49,197 | 50,000 | +803 | 0.01 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,456 | 4,228 | +772 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 728 | +728 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 11,170 | 11,770 | +600 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 427 | +427 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 163,561 | 163,964 | +403 | 0.28 | 0.27 | -0.02 | buy |
| State of Wyoming | 3,793 | 4,178 | +385 | 0.01 | 0.01 | -0.00 | buy |
| COMERICA BANK | 157 | 475 | +318 | 0.00 | 0.00 | +0.00 | buy |
| Johnson Financial Group, Inc. | 0 | 255 | +255 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 215 | +215 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,068 | 1,273 | +205 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 9,731 | 9,919 | +188 | 0.00 | 0.00 | -0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 185 | +185 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,692 | 9,867 | +175 | 0.04 | 0.04 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 60 | 135 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 30 | 44 | +14 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,052 | 1,057 | +5 | 0.00 | 0.00 | -0.00 | buy |