| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 11,109,405 | 12,254,119 | +1,144,714 | 0.09 | 0.13 | +0.04 | buy |
| Rubric Capital Management LP | 10,749,457 | 10,749,457 | 0 | 2.42 | 2.72 | +0.30 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,535,582 | 10,478,000 | -1,057,582 | 6.09 | 5.99 | -0.11 | sell |
| Frazier Life Sciences Management, L.P. | 9,874,511 | 9,874,511 | 0 | 5.54 | 5.58 | +0.04 | hold |
| BlackRock, Inc. | 8,532,761 | 8,573,995 | +41,234 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 7,049,099 | 7,146,090 | +96,991 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 5,006,475 | 5,298,754 | +292,279 | 0.37 | 0.48 | +0.11 | buy |
| STATE STREET CORP | 4,526,937 | 4,641,315 | +114,378 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,155,763 | 4,429,108 | +273,345 | 0.62 | 0.85 | +0.23 | buy |
| MORGAN STANLEY | 4,314,530 | 4,276,394 | -38,136 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 2,937,939 | 2,948,438 | +10,499 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,582,567 | 2,606,465 | +23,898 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,263,960 | 2,398,031 | +134,071 | 0.02 | 0.02 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 2,732,777 | 2,311,019 | -421,758 | 0.01 | 0.01 | +0.00 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,120,508 | 2,120,508 | 0 | 18.43 | 23.11 | +4.68 | hold |
| D. E. Shaw & Co., Inc. | 2,163,001 | 2,118,713 | -44,288 | 0.03 | 0.03 | +0.00 | sell |
| Perpetual Ltd | 26,520 | 2,024,606 | +1,998,086 | 0.00 | 0.47 | +0.47 | buy |
| Ensign Peak Advisors, Inc | 2,001,439 | 1,993,055 | -8,384 | 0.05 | 0.06 | +0.01 | sell |
| GOLDMAN SACHS GROUP INC | 1,890,246 | 1,804,988 | -85,258 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,724,307 | 1,662,470 | -61,837 | 0.01 | 0.02 | +0.00 | sell |
| Nuveen, LLC | 765,579 | 1,370,356 | +604,777 | 0.00 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,378,432 | 1,172,041 | -206,391 | 0.17 | 0.20 | +0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,085,954 | 1,097,004 | +11,050 | 0.12 | 0.15 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 965,066 | 999,434 | +34,368 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 928,688 | 940,202 | +11,514 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,202,513 | 889,285 | -313,228 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 833,490 | +833,490 | 0.00 | 0.05 | +0.05 | buy |
| Qube Research & Technologies Ltd | 577,493 | 814,567 | +237,074 | 0.01 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 790,435 | 778,044 | -12,391 | 0.06 | 0.08 | +0.01 | sell |
| Cormorant Asset Management, LP | 1,000,000 | 775,000 | -225,000 | 1.04 | 1.01 | -0.04 | sell |
| FEDERATED HERMES, INC. | 737,369 | 759,573 | +22,204 | 0.02 | 0.03 | +0.01 | buy |
| Aberdeen Group plc | 675,034 | 675,034 | 0 | 0.02 | 0.02 | +0.00 | hold |
| JUPITER ASSET MANAGEMENT LTD | 412,738 | 659,331 | +246,593 | 0.05 | 0.11 | +0.06 | buy |
| FISHMAN JAY A LTD/MI | 556,150 | 565,650 | +9,500 | 0.75 | 0.91 | +0.17 | buy |
| Tejara Capital Ltd | 873,381 | 520,503 | -352,878 | 5.68 | 5.38 | -0.30 | sell |
| MYDA Advisors LLC | 370,000 | 470,000 | +100,000 | 1.46 | 2.66 | +1.21 | buy |
| AQR CAPITAL MANAGEMENT LLC | 375,233 | 441,315 | +66,082 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 205,672 | 411,893 | +206,221 | 0.93 | 1.57 | +0.64 | buy |
| DEUTSCHE BANK AG\ | 367,415 | 377,528 | +10,113 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 127,122 | 360,770 | +233,648 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 923,375 | 360,460 | -562,915 | 1.12 | 0.58 | -0.54 | sell |
| J. Goldman & Co LP | 860,260 | 353,644 | -506,616 | 0.38 | 0.25 | -0.13 | sell |
| Jump Financial, LLC | 14,562 | 350,485 | +335,923 | 0.00 | 0.10 | +0.10 | buy |
| BARCLAYS PLC | 394,041 | 325,968 | -68,073 | 0.00 | 0.00 | +0.00 | sell |
| Simplify Asset Management Inc. | 409,432 | 317,997 | -91,435 | 0.35 | 0.12 | -0.23 | sell |
| Woodline Partners LP | 205,510 | 314,619 | +109,109 | 0.02 | 0.03 | +0.01 | buy |
| Bank of New York Mellon Corp | 305,258 | 310,620 | +5,362 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 344,472 | 305,972 | -38,500 | 1.02 | 1.04 | +0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 386,011 | 279,619 | -106,392 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 404,736 | 244,015 | -160,721 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 233,220 | +233,220 | 0.00 | 3.68 | +3.68 | buy |
| ALGERT GLOBAL LLC | 98,755 | 229,392 | +130,637 | 0.03 | 0.07 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 341,521 | 224,965 | -116,556 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 268,000 | 214,400 | -53,600 | 0.75 | 0.92 | +0.17 | sell |
| Swiss National Bank | 204,000 | 207,900 | +3,900 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 95,000 | 200,000 | +105,000 | 0.07 | 0.17 | +0.10 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 189,511 | 196,262 | +6,751 | 0.48 | 0.57 | +0.08 | buy |
| Invesco Ltd. | 99,703 | 192,952 | +93,249 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 520,284 | 189,555 | -330,729 | 0.06 | 0.02 | -0.03 | sell |
| ROYAL BANK OF CANADA | 263,809 | 188,280 | -75,529 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 186,099 | 183,129 | -2,970 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 145,493 | 177,268 | +31,775 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 150,730 | 167,974 | +17,244 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 167,814 | 159,847 | -7,967 | 0.01 | 0.01 | +0.00 | sell |
| PDT Partners, LLC | 190,983 | 154,108 | -36,875 | 0.15 | 0.18 | +0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 910,841 | 150,099 | -760,742 | 0.01 | 0.00 | -0.01 | sell |
| Rafferty Asset Management, LLC | 154,351 | 148,295 | -6,056 | 0.01 | 0.01 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 140,000 | 140,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jackson Creek Investment Advisors LLC | 135,871 | 135,819 | -52 | 0.51 | 0.74 | +0.23 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 89,879 | 123,961 | +34,082 | 0.00 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 121,617 | 116,924 | -4,693 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 113,360 | 113,360 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Eversept Partners, LP | 0 | 111,466 | +111,466 | 0.00 | 0.16 | +0.16 | buy |
| Legal & General Group Plc | 111,603 | 109,444 | -2,159 | 0.00 | 0.00 | +0.00 | sell |
| Phocas Financial Corp. | 104,014 | 106,307 | +2,293 | 0.21 | 0.26 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 196,300 | 105,257 | -91,043 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 97,682 | 104,340 | +6,658 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 548,789 | 100,794 | -447,995 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 99,044 | 99,185 | +141 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 113,882 | 96,091 | -17,791 | 0.09 | 0.10 | +0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 66,236 | 95,625 | +29,389 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 71,681 | 95,429 | +23,748 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 84,047 | 87,802 | +3,755 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 86,485 | +86,485 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 90,191 | 79,805 | -10,386 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 29,565 | 76,181 | +46,616 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 73,100 | 73,100 | 0 | 0.01 | 0.01 | +0.00 | hold |
| WESBANCO BANK INC | 102,700 | 71,700 | -31,000 | 0.04 | 0.04 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 69,980 | +69,980 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 66,080 | +66,080 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 31,864 | 66,044 | +34,180 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 260,987 | 65,596 | -195,391 | 0.01 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 64,706 | 65,196 | +490 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 64,485 | 64,485 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 30,863 | 63,025 | +32,162 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 53,623 | 60,074 | +6,451 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 56,717 | 56,717 | 0 | 0.09 | 0.12 | +0.02 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 56,542 | +56,542 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,948 | 56,023 | -1,925 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 86,282 | 50,610 | -35,672 | 0.01 | 0.01 | -0.00 | sell |