| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,135,227 | 8,473,101 | +7,337,874 | 0.33 | 1.25 | +0.93 | buy |
| MORGAN STANLEY | 222,040 | 6,083,072 | +5,861,032 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 4,432,175 | 9,066,082 | +4,633,907 | 0.02 | 0.02 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,292,353 | 4,655,544 | +3,363,191 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 3,117,944 | 6,297,688 | +3,179,744 | 0.12 | 0.13 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 308,949 | 2,558,880 | +2,249,931 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 2,879,460 | 4,896,513 | +2,017,053 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 0 | 1,960,000 | +1,960,000 | 0.00 | 1.68 | +1.68 | buy |
| Rubric Capital Management LP | 5,034,530 | 6,644,530 | +1,610,000 | 1.12 | 0.80 | -0.32 | buy |
| DEUTSCHE BANK AG\ | 30,362 | 1,394,410 | +1,364,048 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 826,095 | 2,029,957 | +1,203,862 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 1,079,580 | +1,079,580 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 978,805 | +978,805 | 0.00 | 0.01 | +0.01 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,105,309 | 1,910,009 | +804,700 | 2.34 | 1.56 | -0.78 | buy |
| Tejara Capital Ltd | 309,179 | 1,112,217 | +803,038 | 0.93 | 1.50 | +0.57 | buy |
| Qube Research & Technologies Ltd | 0 | 725,894 | +725,894 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,037,946 | 1,743,589 | +705,643 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 60,000 | 521,469 | +461,469 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 363,415 | 818,055 | +454,640 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 510,094 | 911,803 | +401,709 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 333,010 | 733,002 | +399,992 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 395,100 | +395,100 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 354,112 | +354,112 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 323,600 | +323,600 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 320,300 | +320,300 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,293 | 328,877 | +290,584 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 289,088 | +289,088 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 483,499 | 730,744 | +247,245 | 0.00 | 0.00 | -0.00 | buy |
| MYDA Advisors LLC | 0 | 220,000 | +220,000 | 0.00 | 0.30 | +0.30 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 194,461 | +194,461 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 383,813 | 571,318 | +187,505 | 0.00 | 0.00 | -0.00 | buy |
| Pennant Investors, LP | 0 | 170,900 | +170,900 | 0.00 | 0.17 | +0.17 | buy |
| J. Goldman & Co LP | 0 | 167,733 | +167,733 | 0.00 | 0.03 | +0.03 | buy |
| Aberdeen Group plc | 0 | 148,874 | +148,874 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 140,000 | +140,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 23,460 | 146,062 | +122,602 | 0.02 | 0.10 | +0.08 | buy |
| Cubist Systematic Strategies, LLC | 0 | 107,168 | +107,168 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 83,513 | 189,643 | +106,130 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 100,000 | +100,000 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 58,858 | 149,423 | +90,565 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 237,779 | 317,927 | +80,148 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 8,684,232 | 8,764,232 | +80,000 | 3.07 | 1.51 | -1.55 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 74,854 | +74,854 | 0.00 | 0.02 | +0.02 | buy |
| Graham Capital Management, L.P. | 0 | 62,417 | +62,417 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 55,818 | +55,818 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 38,282 | 93,212 | +54,930 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 51,686 | +51,686 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 51,442 | +51,442 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 123,025 | 160,601 | +37,576 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 79,430 | 106,931 | +27,501 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 24,356 | +24,356 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,947 | 46,072 | +23,125 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 13,029 | 35,224 | +22,195 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 21,268 | +21,268 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 27,203 | 43,801 | +16,598 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 15,804 | +15,804 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 25,660 | 39,311 | +13,651 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 21,042 | 33,507 | +12,465 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 0 | 12,250 | +12,250 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 11,025 | +11,025 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,419 | +10,419 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 10,114 | +10,114 | 0.00 | 0.01 | +0.01 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 10,000 | 20,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,590 | 10,920 | +9,330 | 0.00 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 10,708 | 19,120 | +8,412 | 0.00 | 0.00 | +0.00 | buy |
| Cape Investment Advisory, Inc. | 0 | 8,004 | +8,004 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,697 | 20,547 | +5,850 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 7,439 | 11,078 | +3,639 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 15,084 | 18,420 | +3,336 | 0.00 | 0.00 | -0.00 | buy |
| First Command Advisory Services, Inc. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,819 | 4,751 | +1,932 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,863 | 4,419 | +556 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 8,984 | 9,523 | +539 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 3,149 | 3,600 | +451 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| FIRST UNITED BANK & TRUST | 0 | 150 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 25,073 | 25,136 | +63 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 7 | 18 | +11 | 0.00 | 0.00 | 0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,071 | 5,071 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 11,398 | 11,398 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ASSETMARK, INC | 1,860 | 1,860 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 81,012 | 81,012 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Lee Financial Co | 2,856 | 2,856 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blackstone Inc. | 24,144 | 24,144 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 245 | 245 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sio Capital Management, LLC | 635,969 | 635,969 | 0 | 1.05 | 0.53 | -0.52 | hold |
| Colonial Trust Advisors | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| First Horizon Advisors, Inc. | 562 | 562 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 3,000,000 | 3,000,000 | 0 | 1.78 | 0.93 | -0.85 | hold |
| Byrne Asset Management LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quarry LP | 3,000 | 3,000 | 0 | 0.01 | 0.00 | -0.01 | hold |
| Erste Asset Management GmbH | 11,100 | 11,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 30 | 30 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 143,935 | 143,935 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 90 | 90 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 48 | 34 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 59 | 0 | -59 | 0.00 | 0.00 | -0.00 | sell |
| HUNTINGTON NATIONAL BANK | 1,202 | 1,127 | -75 | 0.00 | 0.00 | -0.00 | sell |