| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 11,663,497 | 12,339,792 | +676,295 | 0.07 | 0.10 | +0.04 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,721,511 | 11,399,138 | +677,627 | 3.58 | 5.88 | +2.30 | buy |
| Rubric Capital Management LP | 10,966,672 | 10,966,672 | 0 | 1.67 | 2.78 | +1.11 | hold |
| BlackRock, Inc. | 9,029,556 | 9,148,558 | +119,002 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 8,785,284 | 8,785,284 | 0 | 3.27 | 5.08 | +1.80 | hold |
| Polar Capital Holdings Plc | 6,884,372 | 7,377,381 | +493,009 | 0.31 | 0.58 | +0.27 | buy |
| VANGUARD GROUP INC | 6,962,635 | 6,440,715 | -521,920 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 5,641,631 | 4,950,725 | -690,906 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 3,781,195 | 4,243,911 | +462,716 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 3,553,838 | 3,902,991 | +349,153 | 0.40 | 0.59 | +0.19 | buy |
| FRANKLIN RESOURCES INC | 4,250,418 | 3,309,319 | -941,099 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 220,194 | 2,789,530 | +2,569,336 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,745,024 | 2,513,577 | +768,553 | 0.02 | 0.04 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,470,138 | 2,472,730 | +2,592 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 2,416,812 | 2,374,140 | -42,672 | 0.04 | 0.06 | +0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,147,473 | 2,310,163 | +1,162,690 | 0.01 | 0.03 | +0.02 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,120,508 | 2,120,508 | 0 | 11.71 | 19.95 | +8.24 | hold |
| Cormorant Asset Management, LP | 2,325,000 | 1,825,000 | -500,000 | 1.15 | 1.40 | +0.25 | sell |
| Point72 Asset Management, L.P. | 244,386 | 1,753,522 | +1,509,136 | 0.01 | 0.07 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,464,311 | 1,631,226 | +166,915 | 0.01 | 0.01 | +0.01 | buy |
| GW&K Investment Management, LLC | 1,593,630 | 1,544,084 | -49,546 | 0.13 | 0.18 | +0.06 | sell |
| GOLDMAN SACHS GROUP INC | 1,589,882 | 1,306,167 | -283,715 | 0.00 | 0.00 | +0.00 | sell |
| Cercano Management LLC | 0 | 1,255,365 | +1,255,365 | 0.00 | 0.45 | +0.45 | buy |
| JPMORGAN CHASE & CO | 1,296,911 | 1,141,505 | -155,406 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 938,484 | 1,126,668 | +188,184 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,096,769 | +1,096,769 | 0.00 | 0.13 | +0.13 | buy |
| Candriam S.C.A. | 1,426,496 | 1,042,144 | -384,352 | 0.08 | 0.08 | +0.01 | sell |
| NORTHERN TRUST CORP | 936,515 | 991,056 | +54,541 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 1,165,309 | 886,838 | -278,471 | 5.17 | 8.10 | +2.93 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 859,846 | 878,804 | +18,958 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 742,299 | +742,299 | 0.00 | 0.72 | +0.72 | buy |
| J. Goldman & Co LP | 1,492,217 | 612,644 | -879,573 | 0.60 | 0.30 | -0.30 | sell |
| PRUDENTIAL FINANCIAL INC | 572,615 | 592,565 | +19,950 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,175,905 | 536,458 | -639,447 | 0.00 | 0.00 | -0.00 | sell |
| FISHMAN JAY A LTD/MI | 418,000 | 536,400 | +118,400 | 0.39 | 0.70 | +0.31 | buy |
| NORGES BANK | 174,820 | 532,793 | +357,973 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 1,778,318 | 500,966 | -1,277,352 | 4.96 | 1.75 | -3.21 | sell |
| FEDERATED HERMES, INC. | 501,831 | 492,922 | -8,909 | 0.01 | 0.02 | +0.00 | sell |
| Aberdeen Group plc | 482,074 | 482,074 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 803,204 | 388,313 | -414,891 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 800,027 | 387,536 | -412,491 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 89,622 | 327,265 | +237,643 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 0 | 325,709 | +325,709 | 0.00 | 1.03 | +1.03 | buy |
| PDT Partners, LLC | 319,715 | 319,715 | 0 | 0.26 | 0.39 | +0.13 | hold |
| Bank of New York Mellon Corp | 311,059 | 305,007 | -6,052 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 128,443 | 290,938 | +162,495 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 276,691 | 280,100 | +3,409 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 263,137 | +263,137 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 253,392 | 237,941 | -15,451 | 0.00 | 0.00 | +0.00 | sell |
| AMI ASSET MANAGEMENT CORP | 223,681 | 215,958 | -7,723 | 0.11 | 0.16 | +0.05 | sell |
| Rafferty Asset Management, LLC | 276,818 | 210,337 | -66,481 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 203,600 | 206,900 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 252,151 | 204,480 | -47,671 | 0.00 | 0.00 | +0.00 | sell |
| MYDA Advisors LLC | 120,000 | 200,000 | +80,000 | 0.32 | 0.80 | +0.48 | buy |
| Eversept Partners, LP | 693,263 | 191,158 | -502,105 | 0.49 | 0.27 | -0.22 | sell |
| FMR LLC | 171,219 | 184,559 | +13,340 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 163,454 | 168,052 | +4,598 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 151,293 | +151,293 | 0.00 | 0.63 | +0.63 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 163,964 | 142,823 | -21,141 | 0.27 | 0.36 | +0.09 | sell |
| DekaBank Deutsche Girozentrale | 140,000 | 140,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 89,267 | 139,929 | +50,662 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 128,248 | +128,248 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 72,623 | 121,392 | +48,769 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 126,280 | 120,892 | -5,388 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 111,160 | 111,160 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 128,180 | 109,900 | -18,280 | 0.02 | 0.02 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 106,267 | 109,731 | +3,464 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 107,976 | 107,827 | -149 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 111,072 | 105,441 | -5,631 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 103,141 | +103,141 | 0.00 | 0.00 | +0.00 | buy |
| WESBANCO BANK INC | 102,700 | 102,700 | 0 | 0.03 | 0.05 | +0.02 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,654 | 98,544 | -110 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 3,031,073 | 89,168 | -2,941,905 | 0.03 | 0.00 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 173,665 | 84,844 | -88,821 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 72,480 | 80,790 | +8,310 | 0.02 | 0.03 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 79,815 | +79,815 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 92,019 | 77,555 | -14,464 | 0.02 | 0.03 | +0.01 | sell |
| Campbell & CO Investment Adviser LLC | 75,548 | 75,719 | +171 | 0.05 | 0.08 | +0.03 | buy |
| Erste Asset Management GmbH | 11,100 | 73,100 | +62,000 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,369 | 69,354 | -15 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 61,658 | 65,471 | +3,813 | 0.00 | 0.00 | +0.00 | buy |
| Close Asset Management Ltd | 64,774 | 64,774 | 0 | 0.02 | 0.03 | +0.01 | hold |
| TUDOR INVESTMENT CORP ET AL | 20,964 | 64,334 | +43,370 | 0.00 | 0.01 | +0.01 | buy |
| Focus Partners Wealth | 0 | 64,183 | +64,183 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,287 | 64,101 | +13,814 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 59,066 | +59,066 | 0.00 | 0.09 | +0.09 | buy |
| Trexquant Investment LP | 90,204 | 57,658 | -32,546 | 0.01 | 0.01 | -0.00 | sell |
| Corebridge Financial, Inc. | 56,805 | 53,442 | -3,363 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 52,600 | 52,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 35,773 | 52,455 | +16,682 | 0.00 | 0.00 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 42,524 | 52,204 | +9,680 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,503 | 50,956 | -1,547 | 0.00 | 0.00 | +0.00 | sell |
| Parallax Volatility Advisers, L.P. | 50,000 | 50,039 | +39 | 0.01 | 0.02 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 53,149 | 49,267 | -3,882 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 38,333 | 48,087 | +9,754 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 35,100 | 46,300 | +11,200 | 1.31 | 3.38 | +2.07 | buy |
| Legato Capital Management LLC | 56,208 | 42,771 | -13,437 | 0.06 | 0.08 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 60,148 | 42,349 | -17,799 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 37,090 | 42,258 | +5,168 | 0.00 | 0.01 | +0.00 | buy |