| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,478,000 | 11,964,000 | +1,486,000 | 5.99 | 8.66 | +2.67 | buy |
| Frazier Life Sciences Management, L.P. | 9,874,511 | 9,874,511 | 0 | 5.58 | 7.70 | +2.12 | hold |
| BlackRock, Inc. | 8,573,995 | 9,099,579 | +525,584 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 10,749,457 | 8,271,577 | -2,477,880 | 2.72 | 2.87 | +0.15 | sell |
| VANGUARD GROUP INC | 7,146,090 | 7,253,936 | +107,846 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 12,254,119 | 6,758,006 | -5,496,113 | 0.13 | 0.12 | -0.02 | sell |
| Polar Capital Holdings Plc | 5,298,754 | 5,556,169 | +257,415 | 0.48 | 0.74 | +0.26 | buy |
| STATE STREET CORP | 4,641,315 | 5,488,301 | +846,986 | 0.00 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,429,108 | 4,453,856 | +24,748 | 0.85 | 1.37 | +0.51 | buy |
| MORGAN STANLEY | 4,276,394 | 4,340,239 | +63,845 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 2,948,438 | 3,243,432 | +294,994 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,606,465 | 2,753,307 | +146,842 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,118,713 | 2,683,087 | +564,374 | 0.03 | 0.06 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,097,004 | 2,562,445 | +1,465,441 | 0.15 | 0.51 | +0.36 | buy |
| Ensign Peak Advisors, Inc | 1,993,055 | 1,902,390 | -90,665 | 0.06 | 0.10 | +0.04 | sell |
| FRANKLIN RESOURCES INC | 2,311,019 | 1,900,084 | -410,935 | 0.01 | 0.01 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 2,398,031 | 1,830,061 | -567,970 | 0.02 | 0.02 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 889,285 | 1,673,454 | +784,169 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,804,988 | 1,576,413 | -228,575 | 0.00 | 0.01 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,662,470 | 1,467,176 | -195,294 | 0.02 | 0.02 | +0.01 | sell |
| Nuveen, LLC | 1,370,356 | 1,382,160 | +11,804 | 0.01 | 0.01 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,120,508 | 1,366,624 | -753,884 | 23.11 | 15.34 | -7.76 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 87,802 | 1,166,348 | +1,078,546 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 999,434 | 1,014,826 | +15,392 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,172,041 | 1,008,580 | -163,461 | 0.20 | 0.25 | +0.06 | sell |
| NORTHERN TRUST CORP | 940,202 | 955,235 | +15,033 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 377,528 | 930,202 | +552,674 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 833,490 | 914,020 | +80,530 | 0.05 | 0.09 | +0.04 | buy |
| Perpetual Ltd | 2,024,606 | 910,630 | -1,113,976 | 0.47 | 0.38 | -0.09 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 900,000 | +900,000 | 0.00 | 0.04 | +0.04 | buy |
| FEDERATED HERMES, INC. | 759,573 | 891,767 | +132,194 | 0.03 | 0.04 | +0.02 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 808,400 | +808,400 | 0.00 | 0.86 | +0.86 | buy |
| Candriam S.C.A. | 778,044 | 803,138 | +25,094 | 0.08 | 0.12 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 46,146 | 699,803 | +653,657 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 814,567 | 661,415 | -153,152 | 0.02 | 0.03 | +0.01 | sell |
| Nearwater Capital Markets, Ltd | 0 | 615,000 | +615,000 | 0.00 | 0.31 | +0.31 | buy |
| Aberdeen Group plc | 675,034 | 586,397 | -88,637 | 0.02 | 0.03 | +0.01 | sell |
| FISHMAN JAY A LTD/MI | 565,650 | 564,650 | -1,000 | 0.91 | 1.35 | +0.43 | sell |
| MPM BioImpact LLC | 0 | 531,200 | +531,200 | 0.00 | 1.77 | +1.77 | buy |
| BAMCO INC /NY/ | 0 | 504,700 | +504,700 | 0.00 | 0.04 | +0.04 | buy |
| Cormorant Asset Management, LP | 775,000 | 500,000 | -275,000 | 1.01 | 0.82 | -0.18 | sell |
| AQR CAPITAL MANAGEMENT LLC | 441,315 | 499,418 | +58,103 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 159,847 | 455,876 | +296,029 | 0.01 | 0.03 | +0.02 | buy |
| MARSHALL WACE, LLP | 18,300 | 454,233 | +435,933 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 111,466 | 434,634 | +323,168 | 0.16 | 0.71 | +0.55 | buy |
| Jump Financial, LLC | 350,485 | 430,902 | +80,417 | 0.10 | 0.16 | +0.06 | buy |
| Point72 Asset Management, L.P. | 0 | 425,152 | +425,152 | 0.00 | 0.02 | +0.02 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 0 | 418,035 | +418,035 | 0.00 | 0.27 | +0.27 | buy |
| FIRST TRUST ADVISORS LP | 224,965 | 404,654 | +179,689 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 95,429 | 400,862 | +305,433 | 0.00 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 325,968 | 331,578 | +5,610 | 0.00 | 0.00 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 659,331 | 326,538 | -332,793 | 0.11 | 0.08 | -0.03 | sell |
| CASTLEARK MANAGEMENT LLC | 0 | 309,430 | +309,430 | 0.00 | 0.26 | +0.26 | buy |
| Invesco Ltd. | 192,952 | 307,382 | +114,430 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 305,972 | 305,972 | 0 | 1.04 | 1.64 | +0.60 | hold |
| Bank of New York Mellon Corp | 310,620 | 304,428 | -6,192 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 105,257 | 284,243 | +178,986 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 273,999 | +273,999 | 0.00 | 0.01 | +0.01 | buy |
| MYDA Advisors LLC | 470,000 | 265,000 | -205,000 | 2.66 | 2.17 | -0.50 | sell |
| MILLENNIUM MANAGEMENT LLC | 150,099 | 236,770 | +86,671 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 13,935 | 234,915 | +220,980 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 86,485 | 234,071 | +147,586 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 244,015 | 231,734 | -12,281 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 411,893 | 224,740 | -187,153 | 1.57 | 1.12 | -0.45 | sell |
| JANE STREET GROUP, LLC | 360,770 | 221,426 | -139,344 | 0.01 | 0.01 | -0.00 | sell |
| Informed Momentum Co LLC | 0 | 213,863 | +213,863 | 0.00 | 0.69 | +0.69 | buy |
| Swiss National Bank | 207,900 | 212,800 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 0 | 210,000 | +210,000 | 0.00 | 1.31 | +1.31 | buy |
| FMR LLC | 167,974 | 205,424 | +37,450 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 0 | 201,638 | +201,638 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 314,619 | 195,033 | -119,586 | 0.03 | 0.02 | -0.01 | sell |
| Hillsdale Investment Management Inc. | 0 | 179,420 | +179,420 | 0.00 | 0.14 | +0.14 | buy |
| Voleon Capital Management LP | 24,835 | 176,600 | +151,765 | 0.01 | 0.11 | +0.10 | buy |
| NORGES BANK | 0 | 174,820 | +174,820 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 148,295 | 172,066 | +23,771 | 0.01 | 0.02 | +0.01 | buy |
| Walleye Capital LLC | 20,702 | 168,604 | +147,902 | 0.00 | 0.03 | +0.02 | buy |
| RHUMBLINE ADVISERS | 183,129 | 161,402 | -21,727 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 15,100 | 156,100 | +141,000 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 177,268 | 155,158 | -22,110 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 154,108 | 155,075 | +967 | 0.18 | 0.29 | +0.11 | buy |
| RAYMOND JAMES FINANCIAL INC | 60,074 | 144,949 | +84,875 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 196,262 | 141,271 | -54,991 | 0.57 | 0.63 | +0.06 | sell |
| DekaBank Deutsche Girozentrale | 140,000 | 140,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,023 | 125,979 | +69,956 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 113,360 | 116,360 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 113,385 | +113,385 | 0.00 | 0.07 | +0.07 | buy |
| LPL Financial LLC | 116,924 | 111,874 | -5,050 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 100,794 | 106,488 | +5,694 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 69,980 | 106,134 | +36,154 | 0.01 | 0.02 | +0.01 | buy |
| SEI INVESTMENTS CO | 25,863 | 104,286 | +78,423 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 109,444 | 104,013 | -5,431 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 104,340 | 102,439 | -1,901 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 123,961 | 99,247 | -24,714 | 0.01 | 0.01 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 99,185 | 98,826 | -359 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 97,200 | +97,200 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 279,619 | 93,354 | -186,265 | 0.01 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 95,625 | 88,480 | -7,145 | 0.00 | 0.00 | +0.00 | sell |
| Pictet Asset Management Holding SA | 13,159 | 87,687 | +74,528 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 46,283 | 86,605 | +40,322 | 0.01 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 229,392 | 86,260 | -143,132 | 0.07 | 0.04 | -0.03 | sell |