| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,478,000 | 11,964,000 | +1,486,000 | 5.06 | 7.12 | +2.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,097,004 | 2,562,445 | +1,465,441 | 0.15 | 0.51 | +0.36 | buy |
| Eversept Partners, LP | 111,466 | 434,634 | +323,168 | 0.14 | 0.64 | +0.49 | buy |
| Polar Capital Holdings Plc | 5,298,754 | 5,556,169 | +257,415 | 0.48 | 0.74 | +0.26 | buy |
| GW&K Investment Management, LLC | 1,172,041 | 1,008,580 | +163,461 | 0.20 | 0.25 | +0.06 | sell |
| Voleon Capital Management LP | 24,835 | 176,600 | +151,765 | 0.01 | 0.11 | +0.10 | buy |
| Silverleafe Capital Partners, LLC | 16,628 | 62,994 | +46,366 | 0.10 | 0.54 | +0.45 | buy |
| PROFUND ADVISORS LLC | 32,556 | 64,171 | +31,615 | 0.02 | 0.06 | 0.00 | buy |
| Candriam S.C.A. | 778,044 | 803,138 | +25,094 | 0.08 | 0.12 | +0.04 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,429,108 | 4,453,856 | +24,748 | 0.85 | 1.37 | +0.51 | buy |
| Rafferty Asset Management, LLC | 148,295 | 172,066 | +23,771 | 0.01 | 0.02 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 27,367 | 45,758 | +18,391 | 0.02 | 0.06 | +0.04 | buy |
| Virtus Investment Advisers, LLC | 8,429 | 23,549 | +15,120 | 0.05 | 0.19 | +0.14 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 45,015 | 30,883 | +14,132 | 0.00 | 0.00 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 28,849 | 36,736 | +7,887 | 0.08 | 0.16 | +0.08 | buy |
| Independent Advisor Alliance | 20,234 | 25,303 | +5,069 | 0.01 | 0.02 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 11,155 | 13,304 | +2,149 | 0.00 | 0.00 | +0.00 | buy |
| LVW Advisors, LLC | 20,654 | 22,189 | +1,535 | 0.04 | 0.07 | +0.03 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 63,025 | 64,503 | +1,478 | 0.00 | 0.01 | 0.00 | buy |
| PDT Partners, LLC | 154,108 | 155,075 | +967 | 0.18 | 0.29 | +0.11 | buy |
| Quarry LP | 2,154 | 1,200 | +954 | 0.01 | 0.01 | 0.00 | sell |
| DnB Asset Management AS | 26,984 | 27,786 | +802 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 11,352 | 12,144 | +792 | 0.02 | 0.02 | +0.00 | buy |
| C M BIDWELL & ASSOCIATES LTD | 5,270 | 5,335 | +65 | 0.05 | 0.07 | +0.03 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,580 | 2,406 | -174 | 0.00 | 0.00 | +0.00 | sell |
| FISHMAN JAY A LTD/MI | 565,650 | 564,650 | -1,000 | 0.91 | 1.35 | +0.43 | sell |
| China Universal Asset Management Co., Ltd. | 21,018 | 19,960 | -1,058 | 0.03 | 0.04 | +0.01 | sell |
| GK Wealth Management LLC | 17,585 | 14,984 | -2,601 | 0.25 | 0.32 | +0.07 | sell |
| ALTFEST L J & CO INC | 16,712 | 12,830 | -3,882 | 0.04 | 0.04 | +0.01 | sell |
| FIDUCIARY TRUST CO | 16,156 | 10,620 | -5,536 | 0.00 | 0.00 | +0.00 | sell |
| Inspire Investing, LLC | 24,676 | 15,836 | -8,840 | 0.05 | 0.04 | -0.00 | sell |
| Legato Capital Management LLC | 56,717 | 46,028 | -10,689 | 0.12 | 0.12 | -0.00 | sell |
| Close Asset Management Ltd | 38,000 | 19,000 | -19,000 | 0.02 | 0.01 | -0.00 | sell |
| WESBANCO BANK INC | 71,700 | 48,500 | -23,200 | 0.04 | 0.04 | +0.00 | sell |
| Lion Point Capital, LP | 35,300 | 5,250 | -30,050 | 3.78 | 0.79 | -2.99 | sell |
| Phocas Financial Corp. | 106,307 | 64,499 | -41,808 | 0.26 | 0.24 | -0.02 | sell |
| AMI ASSET MANAGEMENT CORP | 96,091 | 49,262 | -46,829 | 0.10 | 0.08 | -0.02 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 196,262 | 141,271 | -54,991 | 0.57 | 0.63 | +0.06 | sell |
| Jackson Creek Investment Advisors LLC | 135,819 | 71,035 | -64,784 | 0.74 | 0.61 | -0.13 | sell |
| Aberdeen Group plc | 675,034 | 586,397 | -88,637 | 0.02 | 0.03 | +0.01 | sell |
| STEMPOINT CAPITAL LP | 411,893 | 224,740 | -187,153 | 1.57 | 1.12 | -0.45 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,662,470 | 1,467,176 | -195,294 | 0.02 | 0.02 | +0.01 | sell |
| MYDA Advisors LLC | 470,000 | 265,000 | -205,000 | 1.91 | 1.47 | -0.45 | sell |
| Cormorant Asset Management, LP | 775,000 | 500,000 | -275,000 | 1.01 | 0.67 | -0.34 | sell |
| JUPITER ASSET MANAGEMENT LTD | 659,331 | 326,538 | -332,793 | 0.11 | 0.08 | -0.03 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,120,508 | 1,366,624 | -753,884 | 23.11 | 15.34 | -7.76 | sell |
| Perpetual Ltd | 2,024,606 | 910,630 | -1,113,976 | 0.47 | 0.38 | -0.09 | sell |
| Rubric Capital Management LP | 10,749,457 | 8,271,577 | -2,477,880 | 2.29 | 2.87 | +0.59 | sell |
| JENNISON ASSOCIATES LLC | 12,254,119 | 6,758,006 | -5,496,113 | 0.13 | 0.12 | -0.02 | sell |