| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 10,478,000 | 11,964,000 | +1,486,000 | 5.99 | 8.66 | +2.67 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,097,004 | 2,562,445 | +1,465,441 | 0.15 | 0.51 | +0.36 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 87,802 | 1,166,348 | +1,078,546 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 900,000 | +900,000 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 4,641,315 | 5,488,301 | +846,986 | 0.00 | 0.01 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 808,400 | +808,400 | 0.00 | 0.86 | +0.86 | buy |
| BANK OF AMERICA CORP /DE/ | 889,285 | 1,673,454 | +784,169 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 46,146 | 699,803 | +653,657 | 0.00 | 0.01 | +0.01 | buy |
| Nearwater Capital Markets, Ltd | 0 | 615,000 | +615,000 | 0.00 | 0.31 | +0.31 | buy |
| D. E. Shaw & Co., Inc. | 2,118,713 | 2,683,087 | +564,374 | 0.03 | 0.06 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 377,528 | 930,202 | +552,674 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 0 | 531,200 | +531,200 | 0.00 | 1.77 | +1.77 | buy |
| BlackRock, Inc. | 8,573,995 | 9,099,579 | +525,584 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 0 | 504,700 | +504,700 | 0.00 | 0.04 | +0.04 | buy |
| MARSHALL WACE, LLP | 18,300 | 454,233 | +435,933 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 425,152 | +425,152 | 0.00 | 0.02 | +0.02 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 0 | 418,035 | +418,035 | 0.00 | 0.27 | +0.27 | buy |
| Eversept Partners, LP | 111,466 | 434,634 | +323,168 | 0.16 | 0.71 | +0.55 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 309,430 | +309,430 | 0.00 | 0.26 | +0.26 | buy |
| TWO SIGMA INVESTMENTS, LP | 95,429 | 400,862 | +305,433 | 0.00 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 159,847 | 455,876 | +296,029 | 0.01 | 0.03 | +0.02 | buy |
| UBS Group AG | 2,948,438 | 3,243,432 | +294,994 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 273,999 | +273,999 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 5,298,754 | 5,556,169 | +257,415 | 0.48 | 0.74 | +0.26 | buy |
| PRUDENTIAL FINANCIAL INC | 13,935 | 234,915 | +220,980 | 0.00 | 0.01 | +0.01 | buy |
| Informed Momentum Co LLC | 0 | 213,863 | +213,863 | 0.00 | 0.69 | +0.69 | buy |
| Patient Square Capital LP | 0 | 210,000 | +210,000 | 0.00 | 1.31 | +1.31 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 0 | 201,638 | +201,638 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 224,965 | 404,654 | +179,689 | 0.00 | 0.01 | +0.01 | buy |
| Hillsdale Investment Management Inc. | 0 | 179,420 | +179,420 | 0.00 | 0.14 | +0.14 | buy |
| WELLS FARGO & COMPANY/MN | 105,257 | 284,243 | +178,986 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 174,820 | +174,820 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 24,835 | 176,600 | +151,765 | 0.01 | 0.11 | +0.10 | buy |
| Walleye Capital LLC | 20,702 | 168,604 | +147,902 | 0.00 | 0.03 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 86,485 | 234,071 | +147,586 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,606,465 | 2,753,307 | +146,842 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 15,100 | 156,100 | +141,000 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 759,573 | 891,767 | +132,194 | 0.03 | 0.04 | +0.02 | buy |
| Invesco Ltd. | 192,952 | 307,382 | +114,430 | 0.00 | 0.00 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 113,385 | +113,385 | 0.00 | 0.07 | +0.07 | buy |
| VANGUARD GROUP INC | 7,146,090 | 7,253,936 | +107,846 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 97,200 | +97,200 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 150,099 | 236,770 | +86,671 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 60,074 | 144,949 | +84,875 | 0.00 | 0.00 | +0.00 | buy |
| Penserra Capital Management LLC | 0 | 82,463 | +82,463 | 0.00 | 0.03 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 833,490 | 914,020 | +80,530 | 0.05 | 0.09 | +0.04 | buy |
| Jump Financial, LLC | 350,485 | 430,902 | +80,417 | 0.10 | 0.16 | +0.06 | buy |
| SEI INVESTMENTS CO | 25,863 | 104,286 | +78,423 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 13,159 | 87,687 | +74,528 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,023 | 125,979 | +69,956 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 4,276,394 | 4,340,239 | +63,845 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 11,303 | 74,358 | +63,055 | 0.01 | 0.06 | +0.05 | buy |
| Aquatic Capital Management LLC | 0 | 60,612 | +60,612 | 0.00 | 0.05 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 441,315 | 499,418 | +58,103 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 22,096 | 78,057 | +55,961 | 0.00 | 0.00 | +0.00 | buy |
| RFG Advisory, LLC | 0 | 54,307 | +54,307 | 0.00 | 0.03 | +0.03 | buy |
| Calamos Advisors LLC | 0 | 54,165 | +54,165 | 0.00 | 0.01 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 49,025 | +49,025 | 0.00 | 0.00 | +0.00 | buy |
| Silverleafe Capital Partners, LLC | 16,628 | 62,994 | +46,366 | 0.10 | 0.54 | +0.45 | buy |
| Jain Global LLC | 0 | 44,816 | +44,816 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 46,283 | 86,605 | +40,322 | 0.01 | 0.03 | +0.02 | buy |
| FMR LLC | 167,974 | 205,424 | +37,450 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 36,833 | +36,833 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 69,980 | 106,134 | +36,154 | 0.01 | 0.02 | +0.01 | buy |
| Handelsbanken Fonder AB | 0 | 34,300 | +34,300 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 32,512 | +32,512 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 32,556 | 64,171 | +31,615 | 0.02 | 0.06 | +0.04 | buy |
| Ellsworth Advisors, LLC | 0 | 29,887 | +29,887 | 0.00 | 0.16 | +0.16 | buy |
| Advisors Asset Management, Inc. | 47,232 | 76,598 | +29,366 | 0.02 | 0.04 | +0.02 | buy |
| D.A. DAVIDSON & CO. | 0 | 28,743 | +28,743 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 26,531 | +26,531 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 778,044 | 803,138 | +25,094 | 0.08 | 0.12 | +0.04 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,429,108 | 4,453,856 | +24,748 | 0.85 | 1.37 | +0.51 | buy |
| Rafferty Asset Management, LLC | 148,295 | 172,066 | +23,771 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,264 | 39,884 | +20,620 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 20,499 | +20,499 | 0.00 | 0.11 | +0.11 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 20,112 | +20,112 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 18,856 | +18,856 | 0.00 | 0.00 | +0.00 | buy |
| Trek Financial, LLC | 0 | 18,605 | +18,605 | 0.00 | 0.03 | +0.03 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 27,367 | 45,758 | +18,391 | 0.01 | 0.06 | +0.05 | buy |
| SG Americas Securities, LLC | 17,415 | 35,229 | +17,814 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 16,837 | +16,837 | 0.00 | 0.06 | +0.06 | buy |
| Vontobel Holding Ltd. | 13,356 | 30,004 | +16,648 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 999,434 | 1,014,826 | +15,392 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,429 | 23,549 | +15,120 | 0.05 | 0.19 | +0.14 | buy |
| NORTHERN TRUST CORP | 940,202 | 955,235 | +15,033 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 14,467 | +14,467 | 0.00 | 0.01 | +0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 14,250 | +14,250 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 14,208 | +14,208 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 0 | 12,950 | +12,950 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 38,939 | 51,585 | +12,646 | 0.00 | 0.00 | +0.00 | buy |
| Financiere des Professionnels - Fonds d,investissement inc. | 0 | 12,434 | +12,434 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 1,370,356 | 1,382,160 | +11,804 | 0.01 | 0.01 | +0.00 | buy |
| Mutual Advisors, LLC | 0 | 10,828 | +10,828 | 0.00 | 0.01 | +0.01 | buy |
| Mariner, LLC | 15,466 | 26,271 | +10,805 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 10,679 | +10,679 | 0.00 | 0.00 | +0.00 | buy |
| Ballentine Partners, LLC | 0 | 10,584 | +10,584 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 10,400 | +10,400 | 0.00 | 0.01 | +0.01 | buy |
| Elo Mutual Pension Insurance Co | 0 | 10,360 | +10,360 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,736 | 14,884 | +10,148 | 0.00 | 0.01 | +0.01 | buy |