| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 7,805,129 | 10,805,129 | +3,000,000 | 0.80 | 1.49 | +0.68 | buy |
| EcoR1 Capital, LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.55 | +0.55 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 1,333,333 | 3,333,333 | +2,000,000 | 3.70 | 9.90 | +6.20 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,400,000 | 5,194,087 | +1,794,087 | 0.41 | 0.98 | +0.56 | buy |
| Cormorant Asset Management, LP | 0 | 1,350,000 | +1,350,000 | 0.00 | 0.64 | +0.64 | buy |
| AMERIPRISE FINANCIAL INC | 10,276 | 1,120,096 | +1,109,820 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 2,868,035 | 3,768,035 | +900,000 | 2.94 | 6.30 | +3.36 | buy |
| T. Rowe Price Investment Management, Inc. | 462,838 | 1,355,321 | +892,483 | 0.00 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 347,381 | 1,189,193 | +841,812 | 1.64 | 8.50 | +6.86 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 838,839 | +838,839 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 800,000 | +800,000 | 0.00 | 0.16 | +0.16 | buy |
| Woodline Partners LP | 0 | 625,129 | +625,129 | 0.00 | 0.06 | +0.06 | buy |
| Commodore Capital LP | 2,730,000 | 3,165,000 | +435,000 | 1.57 | 2.29 | +0.71 | buy |
| CITADEL ADVISORS LLC | 0 | 422,234 | +422,234 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,560,518 | 1,966,271 | +405,753 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 400,100 | +400,100 | 0.00 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,450,000 | 3,800,000 | +350,000 | 0.05 | 0.08 | +0.03 | buy |
| Soleus Capital Management, L.P. | 0 | 300,000 | +300,000 | 0.00 | 0.28 | +0.28 | buy |
| Parkman Healthcare Partners LLC | 0 | 252,028 | +252,028 | 0.00 | 0.33 | +0.33 | buy |
| Octagon Capital Advisors LP | 0 | 240,000 | +240,000 | 0.00 | 0.32 | +0.32 | buy |
| CIBC WORLD MARKETS CORP | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| CIBC WORLD MARKET INC. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 653,740 | 814,408 | +160,668 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 657,772 | 814,872 | +157,100 | 0.01 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 129,374 | +129,374 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 124,119 | +124,119 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 139,945 | 248,147 | +108,202 | 0.00 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 450,731 | 537,580 | +86,849 | 0.02 | 0.04 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 80,000 | +80,000 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 72,898 | +72,898 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 36,642 | 97,196 | +60,554 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 48,100 | +48,100 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,326 | 49,381 | +45,055 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 56,587 | 96,663 | +40,076 | 0.00 | 0.00 | +0.00 | buy |
| THOROUGHBRED FINANCIAL SERVICES, LLC | 0 | 38,340 | +38,340 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 36,410 | +36,410 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 33,540 | +33,540 | 0.00 | 0.00 | +0.00 | buy |
| DENALI ADVISORS LLC | 0 | 26,500 | +26,500 | 0.00 | 0.08 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 69,109 | 89,428 | +20,319 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,348 | 48,172 | +18,824 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 611,849 | 629,155 | +17,306 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 15,969 | +15,969 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 0 | 15,827 | +15,827 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 14,017 | +14,017 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 13,557 | +13,557 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 13,491 | +13,491 | 0.00 | 0.00 | +0.00 | buy |
| Catalina Capital Group, LLC | 0 | 13,483 | +13,483 | 0.00 | 0.06 | +0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,735 | +10,735 | 0.00 | 0.00 | +0.00 | buy |
| Compass Advisory Group LLC | 0 | 10,000 | +10,000 | 0.00 | 0.05 | +0.05 | buy |
| Bleakley Financial Group, LLC | 10,608 | 15,827 | +5,219 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,468 | 8,437 | +1,969 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 1,650 | +1,650 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,330 | 50,894 | +1,564 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,514 | 10,885 | +1,371 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,376 | 3,343 | +967 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 600 | +600 | 0.00 | 0.02 | +0.02 | buy |
| GPS Wealth Strategies Group, LLC | 0 | 424 | +424 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 1,066 | 1,373 | +307 | 0.01 | 0.01 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 37 | +37 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 69 | 94 | +25 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1 | 18 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,431 | 2,431 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 475 | 475 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 66,820 | 66,820 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 550,000 | 550,000 | 0 | 0.34 | 0.62 | +0.28 | hold |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 1.57 | 2.39 | +0.82 | hold |
| Founders Capital Management | 1,000 | 1,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 312 | 312 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 28,988 | 28,988 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAMMA Investing LLC | 238 | 238 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 7,200 | 7,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,356 | 2,356 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 13,474 | 13,418 | -56 | 0.00 | 0.00 | +0.00 | sell |
| Red Tortoise LLC | 906 | 801 | -105 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,030 | 14,901 | -129 | 0.00 | 0.00 | +0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 14,226 | 13,967 | -259 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 10,857 | 10,529 | -328 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 15,793 | 14,260 | -1,533 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 2,743 | 1,125 | -1,618 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,977 | 3,040 | -1,937 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 6,610 | 4,385 | -2,225 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,640 | 2,347 | -2,293 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 34,284 | 31,515 | -2,769 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 320,749 | 317,227 | -3,522 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 4,414 | 0 | -4,414 | 0.00 | 0.00 | -0.00 | sell |
| BOURGEON CAPITAL MANAGEMENT LLC | 4,500 | 0 | -4,500 | 0.01 | 0.00 | -0.01 | sell |
| UPTICK PARTNERS, LLC | 21,200 | 15,200 | -6,000 | 0.12 | 0.13 | +0.01 | sell |
| HSBC HOLDINGS PLC | 18,837 | 12,746 | -6,091 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 23,411 | 13,673 | -9,738 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 105,972 | 95,550 | -10,422 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 10,700 | 0 | -10,700 | 0.00 | 0.00 | -0.00 | sell |
| SIERRA SUMMIT ADVISORS LLC | 11,801 | 0 | -11,801 | 0.02 | 0.00 | -0.02 | sell |
| JPMORGAN CHASE & CO | 357,213 | 345,159 | -12,054 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 32,195 | 20,005 | -12,190 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 12,320 | 0 | -12,320 | 0.04 | 0.00 | -0.04 | sell |