| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 2,293,719 | 7,055,576 | +4,761,857 | 0.38 | 0.72 | +0.34 | buy |
| Monaco Asset Management SAM | 0 | 813,116 | +813,116 | 0.00 | 0.76 | +0.76 | buy |
| Alyeska Investment Group, L.P. | 1,334,696 | 2,064,956 | +730,260 | 0.01 | 0.02 | +0.00 | buy |
| AWM Investment Company, Inc. | 400,000 | 1,000,000 | +600,000 | 0.12 | 0.25 | +0.13 | buy |
| Peapod Lane Capital LLC | 0 | 598,245 | +598,245 | 0.00 | 1.24 | +1.24 | buy |
| AQR CAPITAL MANAGEMENT LLC | 167,806 | 672,078 | +504,272 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 380,444 | 809,366 | +428,922 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 491,043 | 747,044 | +256,001 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 82,240 | +82,240 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 600,857 | 681,068 | +80,211 | 0.00 | 0.00 | -0.00 | buy |
| Samalin Investment Counsel, LLC | 84,575 | 153,425 | +68,850 | 0.09 | 0.11 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 20,000 | 87,800 | +67,800 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 63,764 | +63,764 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,997 | 69,396 | +57,399 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 757,075 | 811,572 | +54,497 | 0.00 | 0.00 | -0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 41,353 | +41,353 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 37,386 | +37,386 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 29,770 | +29,770 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 796 | 28,157 | +27,361 | 0.00 | 0.00 | +0.00 | buy |
| Keel Point, LLC | 0 | 26,403 | +26,403 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 90,811 | 115,999 | +25,188 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 23,925 | +23,925 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,013 | 147,551 | +22,538 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 20,189 | +20,189 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 203,595 | 222,113 | +18,518 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 22,023 | 40,363 | +18,340 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 17,365 | +17,365 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,181,357 | 1,198,313 | +16,956 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 103,500 | 120,300 | +16,800 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 43,157 | 58,812 | +15,655 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 0 | 13,141 | +13,141 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 203,763 | 216,438 | +12,675 | 0.00 | 0.00 | -0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 11,741 | +11,741 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 90,952 | 96,838 | +5,886 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 5,366 | +5,366 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 330 | 4,877 | +4,547 | 0.00 | 0.01 | +0.01 | buy |
| Founders Capital Management | 1,000 | 5,000 | +4,000 | 0.00 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 25,518 | 28,792 | +3,274 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,071 | 10,286 | +3,215 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 600,142 | 603,042 | +2,900 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 469,160 | 471,823 | +2,663 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 2,019 | +2,019 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,379 | 31,705 | +1,326 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,236 | 21,151 | +915 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 312 | 1,062 | +750 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 31,056 | 31,759 | +703 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,125 | 1,826 | +701 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 667 | +667 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 12,386 | 12,861 | +475 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,482 | 1,751 | +269 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 290 | 506 | +216 | 0.00 | 0.00 | +0.00 | buy |
| Banque Transatlantique SA | 0 | 168 | +168 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 500,000 | 500,166 | +166 | 0.01 | 0.01 | -0.00 | buy |
| True Wealth Design, LLC | 3 | 8 | +5 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 821,400 | 821,400 | 0 | 0.04 | 0.04 | -0.01 | hold |
| Ameritas Investment Partners, Inc. | 5,184 | 5,184 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,834 | 3,834 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 80,690 | 80,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | 10,805,129 | 0 | 0.36 | 0.33 | -0.03 | hold |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 0.50 | 0.51 | +0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 28,988 | 28,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 3,768,035 | 3,768,035 | 0 | 1.29 | 1.24 | -0.05 | hold |
| Affinity Asset Advisors, LLC | 800,000 | 800,000 | 0 | 0.31 | 0.23 | -0.08 | hold |
| SBI Securities Co., Ltd. | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 3,333,333 | 3,333,333 | 0 | 2.02 | 1.58 | -0.45 | hold |
| Red Tortoise LLC | 801 | 801 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fortitude Family Office, LLC | 5,408 | 5,408 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UPTICK PARTNERS, LLC | 10,450 | 10,450 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 10,638 | 10,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 103,551 | 103,551 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 22,788 | 22,788 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,567 | 4,567 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,958 | 23,958 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,455 | 8,455 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 299 | 299 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,352 | 2,330 | -22 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 73,845 | 73,805 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 119 | 0 | -119 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 129 | 0 | -129 | 0.00 | 0.00 | 0.00 | sell |
| Bank of New York Mellon Corp | 130,472 | 130,313 | -159 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 26,306 | 25,922 | -384 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 24,413 | 23,731 | -682 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 14,963 | 14,155 | -808 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 1,797 | 951 | -846 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 30,046 | 29,191 | -855 | 0.03 | 0.06 | +0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 16,497 | 15,606 | -891 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 81,191 | 78,185 | -3,006 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 40,880 | 37,824 | -3,056 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 18,244 | 14,637 | -3,607 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 5,300 | 0 | -5,300 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,530,780 | 2,525,107 | -5,673 | 0.00 | 0.00 | -0.00 | sell |
| Bleakley Financial Group, LLC | 11,158 | 0 | -11,158 | 0.00 | 0.00 | -0.00 | sell |
| Sequoia Financial Advisors, LLC | 12,427 | 0 | -12,427 | 0.00 | 0.00 | -0.00 | sell |
| Catalina Capital Group, LLC | 18,818 | 0 | -18,818 | 0.02 | 0.00 | -0.02 | sell |