| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CITADEL ADVISORS LLC | 422,234 | 3,125,434 | +2,703,200 | 0.00 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 1,966,271 | 2,956,374 | +990,103 | 0.00 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 3,165,000 | 4,151,034 | +986,034 | 2.29 | 1.67 | -0.61 | buy |
| STATE STREET CORP | 629,155 | 1,082,493 | +453,338 | 0.00 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 537,580 | 915,382 | +377,802 | 0.04 | 0.03 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 814,408 | 1,137,099 | +322,691 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,694 | 303,461 | +300,767 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 185,869 | 439,973 | +254,104 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 251,914 | +251,914 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 36,426 | 281,677 | +245,251 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 236,190 | +236,190 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 1,168,492 | 1,392,555 | +224,063 | 0.07 | 0.04 | -0.02 | buy |
| Affinity Asset Advisors, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.19 | +0.19 | buy |
| Jefferies Financial Group Inc. | 50,000 | 250,000 | +200,000 | 0.01 | 0.03 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 248,147 | 441,667 | +193,520 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 52,608 | 221,404 | +168,796 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 158,736 | +158,736 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 475 | 135,749 | +135,274 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 177,595 | 301,899 | +124,304 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 117,070 | +117,070 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 814,872 | 912,872 | +98,000 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,100 | 139,975 | +91,875 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 97,196 | 179,194 | +81,998 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 95,550 | 172,162 | +76,612 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 40,372 | 115,009 | +74,637 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,120,096 | 1,191,203 | +71,107 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 67,205 | +67,205 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 89,428 | 145,332 | +55,904 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 39,126 | 88,958 | +49,832 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 44,150 | +44,150 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 129,374 | 173,306 | +43,932 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 31,515 | 72,903 | +41,388 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 96,663 | 132,306 | +35,643 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 35,298 | +35,298 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 50,894 | 84,011 | +33,117 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 317,227 | 343,322 | +26,095 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 48,172 | 72,205 | +24,033 | 0.00 | 0.00 | -0.00 | buy |
| Alpine Global Management, LLC | 0 | 23,161 | +23,161 | 0.00 | 0.02 | +0.02 | buy |
| Simplicity Wealth,LLC | 15,827 | 37,486 | +21,659 | 0.00 | 0.01 | +0.00 | buy |
| Bleakley Financial Group, LLC | 15,827 | 37,486 | +21,659 | 0.00 | 0.01 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 20,872 | +20,872 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 17,994 | +17,994 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 16,928 | +16,928 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 15,969 | 31,197 | +15,228 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 0 | 14,979 | +14,979 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 14,600 | +14,600 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 66,820 | 80,690 | +13,870 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,885 | 23,448 | +12,563 | 0.00 | 0.00 | +0.00 | buy |
| LEVEL FOUR ADVISORY SERVICES, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 0 | 11,833 | +11,833 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,735 | 20,710 | +9,975 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 7,653 | +7,653 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 238 | 4,729 | +4,491 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 4,465 | +4,465 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 49,381 | 52,634 | +3,253 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 625,129 | 628,129 | +3,000 | 0.06 | 0.04 | -0.03 | buy |
| Ameritas Investment Partners, Inc. | 2,431 | 5,184 | +2,753 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 64,948 | 67,549 | +2,601 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 37 | 2,423 | +2,386 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,356 | 4,567 | +2,211 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 3,343 | 4,621 | +1,278 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,040 | 3,834 | +794 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,347 | 3,019 | +672 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 13,967 | 14,392 | +425 | 0.00 | 0.00 | -0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 344 | +344 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 204 | +204 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 47 | 228 | +181 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 13,418 | 13,578 | +160 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,437 | 8,455 | +18 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 800,000 | 800,000 | 0 | 0.16 | 0.09 | -0.06 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 169,467 | 169,467 | 0 | 0.04 | 0.02 | -0.01 | hold |
| TANG CAPITAL MANAGEMENT LLC | 550,000 | 550,000 | 0 | 0.62 | 0.33 | -0.29 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | 10,805,129 | 0 | 1.49 | 0.84 | -0.64 | hold |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 2.39 | 1.59 | -0.81 | hold |
| Founders Capital Management | 1,000 | 1,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 312 | 312 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 28,988 | 28,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 3,768,035 | 3,768,035 | 0 | 6.30 | 4.66 | -1.64 | hold |
| Octagon Capital Advisors LP | 240,000 | 240,000 | 0 | 0.32 | 0.23 | -0.08 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 3,333,333 | 3,333,333 | 0 | 9.90 | 6.17 | -3.73 | hold |
| Red Tortoise LLC | 801 | 801 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UPTICK PARTNERS, LLC | 15,200 | 15,200 | 0 | 0.13 | 0.13 | +0.00 | hold |
| Erste Asset Management GmbH | 7,200 | 7,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,125 | 1,125 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 94 | 88 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 18 | 1 | -17 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 23 | 0 | -23 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 1,373 | 1,066 | -307 | 0.01 | 0.00 | -0.01 | sell |
| GPS Wealth Strategies Group, LLC | 424 | 0 | -424 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 600 | 0 | -600 | 0.02 | 0.00 | -0.02 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,650 | 0 | -1,650 | 0.00 | 0.00 | -0.00 | sell |
| Catalina Capital Group, LLC | 13,483 | 11,622 | -1,861 | 0.06 | 0.03 | -0.04 | sell |
| DEUTSCHE BANK AG\ | 20,005 | 17,463 | -2,542 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 4,385 | 315 | -4,070 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 4,500 | 0 | -4,500 | 0.01 | 0.00 | -0.01 | sell |
| Compass Advisory Group LLC | 10,000 | 0 | -10,000 | 0.05 | 0.00 | -0.05 | sell |