| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 800,000 | 1,480,600 | +680,600 | 0.09 | 0.12 | +0.03 | buy |
| Commodore Capital LP | 4,151,034 | 4,662,073 | +511,039 | 1.67 | 1.32 | -0.36 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 650,000 | +450,000 | 0.14 | 0.40 | +0.26 | buy |
| WASATCH ADVISORS LP | 1,392,555 | 1,834,680 | +442,125 | 0.04 | 0.04 | -0.00 | buy |
| Blackstone Inc. | 236,190 | 491,043 | +254,853 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 915,382 | 1,084,696 | +169,314 | 0.03 | 0.03 | -0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 550,000 | 650,000 | +100,000 | 0.33 | 0.21 | -0.12 | buy |
| Forefront Analytics, LLC | 11,833 | 17,646 | +5,813 | 0.03 | 0.04 | +0.00 | buy |
| Woodline Partners LP | 628,129 | 629,358 | +1,229 | 0.04 | 0.02 | -0.01 | buy |
| Catalina Capital Group, LLC | 11,622 | 11,951 | +329 | 0.03 | 0.02 | -0.01 | buy |
| UPTICK PARTNERS, LLC | 15,200 | 10,450 | -4,750 | 0.13 | 0.02 | -0.11 | sell |
| T. Rowe Price Investment Management, Inc. | 808,566 | 792,809 | -15,757 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 240,000 | 120,000 | -120,000 | 0.23 | 0.09 | -0.15 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 875,999 | 740,294 | -135,705 | 6.53 | 2.99 | -3.53 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,799,143 | 2,155,000 | -1,644,143 | 0.37 | 0.15 | -0.23 | sell |