| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 302,013 | 1,063,362 | +761,349 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 800,000 | 1,480,600 | +680,600 | 0.09 | 0.12 | +0.03 | buy |
| Commodore Capital LP | 4,151,034 | 4,662,073 | +511,039 | 1.67 | 1.32 | -0.36 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 650,000 | +450,000 | 0.19 | 0.46 | +0.27 | buy |
| WASATCH ADVISORS LP | 1,392,555 | 1,834,680 | +442,125 | 0.04 | 0.04 | -0.00 | buy |
| Blackstone Inc. | 236,190 | 491,043 | +254,853 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 221,404 | 423,233 | +201,829 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 915,382 | 1,084,696 | +169,314 | 0.03 | 0.03 | -0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 158,736 | 314,350 | +155,614 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 132,306 | 283,176 | +150,870 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 44,150 | 194,350 | +150,200 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 88,958 | 232,566 | +143,608 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 303,461 | 432,783 | +129,322 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 343,322 | 466,303 | +122,981 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 550,000 | 650,000 | +100,000 | 0.33 | 0.21 | -0.12 | buy |
| AMERIPRISE FINANCIAL INC | 1,191,203 | 1,268,476 | +77,273 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 301,899 | 374,396 | +72,497 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 115,009 | 181,099 | +66,090 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 67,549 | 133,149 | +65,600 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,956,374 | 3,009,940 | +53,566 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 49,283 | +49,283 | 0.00 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 173,306 | 216,341 | +43,035 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 36,412 | +36,412 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,137,099 | 1,171,026 | +33,927 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 33,345 | +33,345 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 23,480 | +23,480 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 0 | 20,597 | +20,597 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 72,903 | 93,366 | +20,463 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 17,463 | 34,211 | +16,748 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 16,274 | +16,274 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,082,493 | 1,098,062 | +15,569 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,643 | 29,087 | +14,444 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 3,125,434 | 3,139,235 | +13,801 | 0.02 | 0.01 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 72,205 | 83,574 | +11,369 | 0.00 | 0.00 | -0.00 | buy |
| Forefront Analytics, LLC | 11,833 | 17,646 | +5,813 | 0.03 | 0.04 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 5,300 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 4,729 | 9,972 | +5,243 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 4,450 | +4,450 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 78,401 | 81,452 | +3,051 | 0.00 | 0.00 | -0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,019 | 4,415 | +1,396 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 628,129 | 629,358 | +1,229 | 0.04 | 0.02 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 23,448 | 24,293 | +845 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 538 | +538 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 228 | 573 | +345 | 0.00 | 0.00 | +0.00 | buy |
| Catalina Capital Group, LLC | 11,622 | 11,951 | +329 | 0.03 | 0.02 | -0.01 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 121 | +121 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 119 | +119 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 88 | 180 | +92 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 4,621 | 4,664 | +43 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,184 | 5,184 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,834 | 3,834 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 169,467 | 169,467 | 0 | 0.02 | 0.02 | -0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 80,690 | 80,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,600,000 | 3,600,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| CIBC Private Wealth Group LLC | 344 | 344 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | 10,805,129 | 0 | 0.84 | 0.56 | -0.28 | hold |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 1.59 | 0.88 | -0.71 | hold |
| MetLife Investment Management, LLC | 31,197 | 31,197 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 204 | 204 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Founders Capital Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 312 | 312 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 28,988 | 28,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 3,768,035 | 3,768,035 | 0 | 4.66 | 3.27 | -1.39 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 3,333,333 | 3,333,333 | 0 | 6.17 | 3.02 | -3.15 | hold |
| Red Tortoise LLC | 801 | 801 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fortitude Family Office, LLC | 1,066 | 1,066 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 7,200 | 7,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,567 | 4,567 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,928 | 16,928 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MEEDER ASSET MANAGEMENT INC | 4,465 | 4,465 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,455 | 8,455 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 145,332 | 145,332 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,125 | 1,125 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jefferies Financial Group Inc. | 250,000 | 250,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| NATIONAL BANK OF CANADA /FI/ | 300 | 299 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 28,466 | 28,292 | -174 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 315 | 129 | -186 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 14,392 | 14,051 | -341 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 17,994 | 17,507 | -487 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,710 | 20,087 | -623 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 13,578 | 12,529 | -1,049 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 2,423 | 0 | -2,423 | 0.00 | 0.00 | -0.00 | sell |
| UPTICK PARTNERS, LLC | 15,200 | 10,450 | -4,750 | 0.13 | 0.02 | -0.11 | sell |
| RHUMBLINE ADVISERS | 84,011 | 79,056 | -4,955 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 7,653 | 2,533 | -5,120 | 0.00 | 0.00 | -0.00 | sell |
| LEVEL FOUR ADVISORY SERVICES, LLC | 12,000 | 0 | -12,000 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 52,634 | 40,451 | -12,183 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 14,600 | 0 | -14,600 | 0.00 | 0.00 | -0.00 | sell |
| Bayesian Capital Management, LP | 14,979 | 0 | -14,979 | 0.01 | 0.00 | -0.01 | sell |