| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | 10,805,129 | 0 | 0.30 | 0.28 | -0.03 | hold |
| TANG CAPITAL MANAGEMENT LLC | 7,055,576 | 7,055,576 | 0 | 0.59 | 0.56 | -0.03 | hold |
| Samsara BioCapital, LLC | 3,768,035 | 3,768,035 | 0 | 1.28 | 1.02 | -0.26 | hold |
| BlackRock, Inc. | 4,153,845 | 3,698,537 | -455,308 | 0.00 | 0.00 | +0.00 | sell |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 0.45 | 0.41 | -0.04 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 3,333,333 | 3,333,333 | 0 | 1.20 | 1.00 | -0.20 | hold |
| CITADEL ADVISORS LLC | 3,297,824 | 2,899,758 | -398,066 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 2,554,282 | 2,491,717 | -62,565 | 0.00 | 0.00 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 2,084,696 | 2,084,696 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Monaco Asset Management SAM | 1,583,372 | 1,970,910 | +387,538 | 1.00 | 1.52 | +0.52 | buy |
| WASATCH ADVISORS LP | 1,786,214 | 1,637,737 | -148,477 | 0.02 | 0.02 | +0.00 | sell |
| STATE STREET CORP | 1,137,942 | 1,148,115 | +10,173 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 696,372 | 1,145,077 | +448,705 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,208,378 | 1,068,105 | -140,273 | 0.00 | 0.00 | +0.00 | sell |
| AWM Investment Company, Inc. | 700,000 | 800,000 | +100,000 | 0.13 | 0.16 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 748,494 | +748,494 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 747,044 | 747,044 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Peapod Lane Capital LLC | 663,850 | 671,266 | +7,416 | 1.10 | 1.24 | +0.14 | buy |
| JPMORGAN CHASE & CO | 578,012 | 558,840 | -19,172 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 271,962 | 520,172 | +248,210 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 475,887 | 510,696 | +34,809 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 742,718 | 442,493 | -300,225 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 406,072 | 406,634 | +562 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 449,518 | 392,565 | -56,953 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 462,169 | 376,916 | -85,253 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 500,166 | 375,166 | -125,000 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 593,799 | 280,783 | -313,016 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 364,218 | 234,740 | -129,478 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 88,400 | 192,900 | +104,500 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 114,266 | 181,600 | +67,334 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 161,778 | +161,778 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 280,312 | 144,147 | -136,165 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 149,530 | 143,293 | -6,237 | 0.00 | 0.00 | +0.00 | sell |
| Samalin Investment Counsel, LLC | 156,425 | 140,165 | -16,260 | 0.10 | 0.10 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161,776 | 129,175 | -32,601 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 132,496 | 128,419 | -4,077 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 122,834 | 128,041 | +5,207 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 116,138 | 117,904 | +1,766 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 99,297 | 116,844 | +17,547 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 26,755 | 107,320 | +80,565 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 130,739 | 95,563 | -35,176 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 98,097 | 95,205 | -2,892 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 67,193 | 94,955 | +27,762 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 89,870 | 89,870 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 87,800 | 87,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 0 | 84,914 | +84,914 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 78,522 | 70,759 | -7,763 | 0.00 | 0.00 | +0.00 | sell |
| IEQ CAPITAL, LLC | 81,917 | 67,339 | -14,578 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 231,081 | 54,335 | -176,746 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 49,274 | +49,274 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 48,512 | +48,512 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 43,628 | +43,628 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 43,300 | +43,300 | 0.00 | 0.01 | +0.01 | buy |
| Forefront Analytics, LLC | 27,979 | 39,452 | +11,473 | 0.02 | 0.08 | +0.06 | buy |
| Forefront Wealth Partners, LLC | 0 | 39,452 | +39,452 | 0.00 | 0.02 | +0.02 | buy |
| Quadrature Capital Ltd | 0 | 37,289 | +37,289 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 35,701 | +35,701 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 34,340 | +34,340 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 33,676 | 33,240 | -436 | 0.00 | 0.00 | +0.00 | sell |
| Graham Capital Management, L.P. | 0 | 32,400 | +32,400 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 28,030 | 30,338 | +2,308 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 29,600 | +29,600 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,196 | 28,922 | +3,726 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 34,758 | 28,512 | -6,246 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 27,843 | 27,843 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 32,197 | 26,427 | -5,770 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 0 | 26,290 | +26,290 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 58,812 | 25,736 | -33,076 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 17,522 | 23,663 | +6,141 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 22,898 | 22,898 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Savant Capital, LLC | 21,986 | 21,365 | -621 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,379 | 19,763 | -10,616 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 21,620 | 19,293 | -2,327 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 16,874 | +16,874 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 13,104 | 13,609 | +505 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,252 | 12,450 | -1,802 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 20,359 | 11,974 | -8,385 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 11,320 | 11,320 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Pallas Capital Advisors LLC | 12,836 | 10,738 | -2,098 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 10,638 | 10,638 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLVERINE TRADING, LLC | 0 | 10,188 | +10,188 | 0.00 | 0.00 | +0.00 | buy |
| Merit Financial Group, LLC | 10,668 | 10,085 | -583 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,455 | 8,455 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 435 | 7,231 | +6,796 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,064 | 6,977 | +1,913 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 6,270 | +6,270 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 6,094 | +6,094 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 3,805 | 5,615 | +1,810 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,184 | 5,184 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Founders Capital Management | 5,000 | 5,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Legal & General Group Plc | 4,567 | 4,567 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 0 | 4,166 | +4,166 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 3,896 | +3,896 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 2,320 | 3,420 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 3,330 | +3,330 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,418 | 2,935 | +1,517 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,741 | 2,746 | +5 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,826 | 1,826 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 1,768 | 1,771 | +3 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,751 | 1,463 | -288 | 0.00 | 0.00 | -0.00 | sell |