| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 3,400,000 | +3,400,000 | 0.00 | 0.41 | +0.41 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 139,300 | 3,450,000 | +3,310,700 | 0.00 | 0.05 | +0.05 | buy |
| Commodore Capital LP | 0 | 2,730,000 | +2,730,000 | 0.00 | 1.57 | +1.57 | buy |
| WASATCH ADVISORS LP | 1,847,904 | 2,099,699 | +251,795 | 0.02 | 0.08 | +0.06 | buy |
| MARSHALL WACE, LLP | 0 | 250,667 | +250,667 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 215,013 | +215,013 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 201,752 | +201,752 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 146,231 | +146,231 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 512,572 | 657,772 | +145,200 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 139,945 | +139,945 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,358 | 138,713 | +134,355 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 122,145 | +122,145 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,162 | 105,869 | +91,707 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,498,740 | 1,560,518 | +61,778 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 36,642 | +36,642 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 45,142 | 81,139 | +35,997 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 34,284 | +34,284 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 32,469 | +32,469 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 24,415 | 56,587 | +32,172 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 14,431 | 45,426 | +30,995 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 28,988 | +28,988 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 64,549 | 90,669 | +26,120 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,794 | 32,195 | +25,401 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 632,727 | 653,740 | +21,013 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 16,113 | +16,113 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 10,857 | +10,857 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 10,608 | +10,608 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 9,514 | +9,514 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 71,498 | 79,168 | +7,670 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,817 | 29,348 | +7,531 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 11,275 | 17,877 | +6,602 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 607,304 | 611,849 | +4,545 | 0.00 | 0.00 | +0.00 | buy |
| BOURGEON CAPITAL MANAGEMENT LLC | 0 | 4,500 | +4,500 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 1,615 | 4,414 | +2,799 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 11,613 | 14,226 | +2,613 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 14,505 | 15,793 | +1,288 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 18,813 | 18,837 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,431 | 2,431 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 49,330 | 49,330 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,805,129 | 7,805,129 | 0 | 0.21 | 0.80 | +0.59 | hold |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 0.38 | 1.57 | +1.19 | hold |
| Founders Capital Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 312 | 312 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 2,868,035 | 2,868,035 | 0 | 1.22 | 2.94 | +1.72 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 1,333,333 | 1,333,333 | 0 | 0.95 | 3.70 | +2.75 | hold |
| Red Tortoise LLC | 906 | 906 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Erste Asset Management GmbH | 7,200 | 7,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 69,109 | 69,109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 69 | 69 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 250,000 | 250,000 | 0 | 0.01 | 0.03 | +0.02 | hold |
| LAZARD ASSET MANAGEMENT LLC | 6,635 | 6,610 | -25 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,515 | 6,468 | -47 | 0.00 | 0.00 | +0.00 | sell |
| Steward Partners Investment Advisory, LLC | 57 | 0 | -57 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,091 | 15,030 | -61 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 10,403 | 10,276 | -127 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 180 | 0 | -180 | 0.00 | 0.00 | 0.00 | sell |
| AMALGAMATED BANK | 3,078 | 2,743 | -335 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 3,078 | 2,356 | -722 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 5,242 | 4,326 | -916 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 996 | 0 | -996 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 107,065 | 105,972 | -1,093 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 3,499 | 2,376 | -1,123 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,265 | 0 | -1,265 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,672 | 4,977 | -1,695 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 322,632 | 320,749 | -1,883 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 2,087 | 0 | -2,087 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 100,294 | 97,660 | -2,634 | 0.00 | 0.01 | +0.01 | sell |
| Quantbot Technologies LP | 3,900 | 0 | -3,900 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 70,820 | 66,820 | -4,000 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 5,012 | 475 | -4,537 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 10,754 | 4,640 | -6,114 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 366,577 | 357,213 | -9,364 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 14,929 | 0 | -14,929 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 16,419 | 0 | -16,419 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 30,948 | 13,474 | -17,474 | 0.00 | 0.00 | +0.00 | sell |
| Forefront Analytics, LLC | 39,657 | 20,767 | -18,890 | 0.03 | 0.07 | +0.04 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 38,645 | 0 | -38,645 | 0.01 | 0.00 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 107,780 | 63,280 | -44,500 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 63,384 | 0 | -63,384 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 78,100 | 10,700 | -67,400 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 605,167 | 379,467 | -225,700 | 0.02 | 0.05 | +0.03 | sell |
| Monaco Asset Management SAM | 235,236 | 0 | -235,236 | 0.16 | 0.00 | -0.16 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 255,123 | 0 | -255,123 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 263,274 | 0 | -263,274 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 526,626 | 207,264 | -319,362 | 0.00 | 0.00 | +0.00 | sell |
| Rock Springs Capital Management LP | 331,571 | 0 | -331,571 | 0.01 | 0.00 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 1,000,000 | 450,731 | -549,269 | 0.01 | 0.02 | +0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,103,638 | 550,000 | -553,638 | 0.22 | 0.34 | +0.12 | sell |
| Laurion Capital Management LP | 1,197,060 | 0 | -1,197,060 | 0.04 | 0.00 | -0.04 | sell |
| T. Rowe Price Investment Management, Inc. | 4,501,485 | 462,838 | -4,038,647 | 0.00 | 0.00 | -0.00 | sell |