| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | 10,805,129 | 0 | 0.56 | 0.36 | -0.21 | hold |
| BlackRock, Inc. | 4,222,380 | 4,650,498 | +428,118 | 0.00 | 0.00 | -0.00 | buy |
| Samsara BioCapital, LLC | 3,768,035 | 3,768,035 | 0 | 3.27 | 1.29 | -1.99 | hold |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 0.88 | 0.50 | -0.38 | hold |
| CITADEL ADVISORS LLC | 3,139,235 | 3,564,568 | +425,333 | 0.01 | 0.01 | -0.01 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 3,333,333 | 3,333,333 | 0 | 3.02 | 2.02 | -1.00 | hold |
| JPMORGAN CHASE & CO | 1,063,362 | 2,537,922 | +1,474,560 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,009,940 | 2,530,780 | -479,160 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 1,834,680 | 2,520,909 | +686,229 | 0.04 | 0.03 | -0.01 | buy |
| Jefferies Financial Group Inc. | 250,000 | 2,504,219 | +2,254,219 | 0.02 | 0.07 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 650,000 | 2,293,719 | +1,643,719 | 0.21 | 0.38 | +0.17 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,155,000 | 2,155,000 | 0 | 0.15 | 0.10 | -0.04 | hold |
| MORGAN STANLEY | 374,396 | 1,754,344 | +1,379,948 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 1,084,696 | 1,334,696 | +250,000 | 0.03 | 0.01 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,171,026 | 1,181,357 | +10,331 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,098,062 | 1,137,002 | +38,940 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 432,783 | 849,801 | +417,018 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,480,600 | 821,400 | -659,200 | 0.12 | 0.04 | -0.08 | sell |
| Affinity Asset Advisors, LLC | 650,000 | 800,000 | +150,000 | 0.46 | 0.31 | -0.14 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 884,272 | 757,075 | -127,197 | 0.01 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 676,519 | +676,519 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 423,233 | 600,857 | +177,624 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 235,725 | 600,142 | +364,417 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 283,176 | 569,357 | +286,181 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 629,358 | 500,000 | -129,358 | 0.02 | 0.01 | -0.02 | sell |
| Blackstone Inc. | 491,043 | 491,043 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHERN TRUST CORP | 466,303 | 469,160 | +2,857 | 0.00 | 0.00 | -0.00 | buy |
| AWM Investment Company, Inc. | 0 | 400,000 | +400,000 | 0.00 | 0.12 | +0.12 | buy |
| BANK OF AMERICA CORP /DE/ | 181,099 | 380,444 | +199,345 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 4,662,073 | 351,848 | -4,310,225 | 1.32 | 0.06 | -1.25 | sell |
| UBS Group AG | 93,366 | 281,668 | +188,302 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 232,566 | 270,857 | +38,291 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 247,227 | +247,227 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 216,341 | 225,224 | +8,883 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 2,533 | 204,994 | +202,461 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 326,984 | 203,763 | -123,221 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 203,595 | +203,595 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 314,350 | 167,806 | -146,544 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 133,149 | 145,311 | +12,162 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 194,350 | 144,850 | -49,500 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 130,471 | 130,472 | +1 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 145,332 | 125,013 | -20,319 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 116,128 | 109,906 | -6,222 | 0.01 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 103,551 | +103,551 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 103,500 | +103,500 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 83,574 | 90,952 | +7,378 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 81,452 | 90,811 | +9,359 | 0.00 | 0.00 | -0.00 | buy |
| Samalin Investment Counsel, LLC | 0 | 84,575 | +84,575 | 0.00 | 0.09 | +0.09 | buy |
| Aristides Capital LLC | 0 | 84,400 | +84,400 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 79,056 | 81,191 | +2,135 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 80,690 | 80,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 36,412 | 73,845 | +37,433 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 73,387 | +73,387 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 122,902 | 70,600 | -52,302 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 34,211 | 43,157 | +8,946 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 40,451 | 40,880 | +429 | 0.00 | 0.00 | -0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 33,426 | +33,426 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 24,293 | 31,056 | +6,763 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,087 | 30,379 | +1,292 | 0.00 | 0.00 | -0.00 | buy |
| Forefront Analytics, LLC | 17,646 | 30,046 | +12,400 | 0.04 | 0.03 | -0.00 | buy |
| Aberdeen Group plc | 28,988 | 28,988 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corebridge Financial, Inc. | 28,292 | 26,306 | -1,986 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 16,274 | 25,518 | +9,244 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 20,597 | 24,413 | +3,816 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,928 | 23,958 | +7,030 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 0 | 22,788 | +22,788 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 14,051 | 22,023 | +7,972 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,087 | 20,236 | +149 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 169,467 | 20,000 | -149,467 | 0.02 | 0.00 | -0.02 | sell |
| Catalina Capital Group, LLC | 11,951 | 18,818 | +6,867 | 0.02 | 0.02 | -0.00 | buy |
| ProShare Advisors LLC | 0 | 18,244 | +18,244 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 17,507 | 16,497 | -1,010 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 0 | 14,963 | +14,963 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 0 | 12,427 | +12,427 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 12,529 | 12,386 | -143 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 0 | 11,997 | +11,997 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 15,284 | 11,158 | -4,126 | 0.00 | 0.00 | -0.00 | sell |
| UPTICK PARTNERS, LLC | 10,450 | 10,450 | 0 | 0.02 | 0.01 | -0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,455 | 8,455 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 4,415 | 7,071 | +2,656 | 0.00 | 0.00 | -0.00 | buy |
| Fortitude Family Office, LLC | 1,066 | 5,408 | +4,342 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 5,300 | 5,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,184 | 5,184 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,567 | 4,567 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,834 | 3,834 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,352 | +2,352 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 168 | 1,797 | +1,629 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,125 | 1,125 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Founders Capital Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Red Tortoise LLC | 801 | 801 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 4,664 | 796 | -3,868 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 312 | 312 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 299 | 299 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 180 | 290 | +110 | 0.00 | 0.00 | -0.00 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 129 | 129 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Avior Wealth Management, LLC | 119 | 119 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MAI Capital Management | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| True Wealth Design, LLC | 100 | 3 | -97 | 0.00 | 0.00 | -0.00 | sell |