| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,805,129 | 10,805,129 | 0 | 0.28 | 0.20 | -0.07 | hold |
| BlackRock, Inc. | 3,698,537 | 4,115,138 | +416,601 | 0.00 | 0.00 | -0.00 | buy |
| NEA Management Company, LLC | 3,568,781 | 3,568,781 | 0 | 0.41 | 0.34 | -0.07 | hold |
| Samsara BioCapital, LLC | 3,768,035 | 3,507,666 | -260,369 | 1.02 | 0.67 | -0.35 | sell |
| SR ONE CAPITAL MANAGEMENT, LP | 3,333,333 | 3,333,333 | 0 | 1.00 | 0.87 | -0.12 | hold |
| VANGUARD GROUP INC | 2,491,717 | 2,597,370 | +105,653 | 0.00 | 0.00 | -0.00 | buy |
| Monaco Asset Management SAM | 1,970,910 | 2,546,932 | +576,022 | 1.52 | 1.40 | -0.12 | buy |
| Alyeska Investment Group, L.P. | 2,084,696 | 2,084,840 | +144 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,145,077 | 1,702,022 | +556,945 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 1,637,737 | 1,576,282 | -61,455 | 0.02 | 0.02 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 7,055,576 | 1,480,823 | -5,574,753 | 0.56 | 0.14 | -0.43 | sell |
| CITADEL ADVISORS LLC | 2,899,758 | 1,345,233 | -1,554,525 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,148,115 | 1,169,356 | +21,241 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,068,105 | 1,154,323 | +86,218 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 520,172 | 971,982 | +451,810 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 800,000 | 906,000 | +106,000 | 0.16 | 0.16 | +0.01 | buy |
| Blackstone Inc. | 747,044 | 747,044 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 510,696 | 692,087 | +181,391 | 0.00 | 0.00 | +0.00 | buy |
| Peapod Lane Capital LLC | 671,266 | 676,199 | +4,933 | 1.24 | 1.06 | -0.18 | buy |
| TWO SIGMA ADVISERS, LP | 192,900 | 647,200 | +454,300 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 558,840 | 598,985 | +40,145 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 376,916 | 359,626 | -17,290 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 280,783 | 340,241 | +59,458 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 392,565 | 318,992 | -73,573 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 181,600 | 284,210 | +102,610 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 375,166 | 250,848 | -124,318 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 161,778 | 243,704 | +81,926 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 206,682 | +206,682 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 234,740 | 198,699 | -36,041 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 95,563 | 190,683 | +95,120 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 144,147 | 183,923 | +39,776 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 183,369 | +183,369 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 94,955 | 161,434 | +66,479 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 84,914 | 155,036 | +70,122 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 116,844 | 150,476 | +33,632 | 0.00 | 0.00 | -0.00 | buy |
| Samalin Investment Counsel, LLC | 140,165 | 150,235 | +10,070 | 0.10 | 0.10 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 143,293 | 142,835 | -458 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 16,874 | 134,730 | +117,856 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129,175 | 129,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 117,904 | 119,618 | +1,714 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 128,419 | 117,228 | -11,191 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 128,041 | 110,033 | -18,008 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 87,800 | 107,800 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 748,494 | 104,652 | -643,842 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 95,205 | 95,205 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 89,870 | 89,870 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Man Group plc | 43,628 | 88,438 | +44,810 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 43,300 | 73,300 | +30,000 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 70,759 | 66,988 | -3,771 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 29,600 | 63,400 | +33,800 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 67,339 | 59,821 | -7,518 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 55,168 | +55,168 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 39,452 | 40,702 | +1,250 | 0.08 | 0.07 | -0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 54,335 | 40,017 | -14,318 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 107,320 | 37,275 | -70,045 | 0.00 | 0.00 | -0.00 | sell |
| Rangeley Capital, LLC | 0 | 32,078 | +32,078 | 0.00 | 0.05 | +0.05 | buy |
| Graham Capital Management, L.P. | 32,400 | 31,751 | -649 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,922 | 28,922 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF MONTREAL /CAN/ | 27,843 | 27,843 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cerity Partners LLC | 33,240 | 23,394 | -9,846 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 28,512 | 23,274 | -5,238 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 22,898 | 22,898 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 37,289 | 22,111 | -15,178 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 23,663 | 21,218 | -2,445 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 30,338 | 20,895 | -9,443 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,763 | 20,379 | +616 | 0.00 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 19,970 | +19,970 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 26,427 | 19,232 | -7,195 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 48,512 | 17,562 | -30,950 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 19,293 | 14,998 | -4,295 | 0.00 | 0.00 | -0.00 | sell |
| Abel Hall, LLC | 0 | 14,578 | +14,578 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 14,200 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 13,609 | 13,151 | -458 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 11,320 | 11,320 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 0 | 10,994 | +10,994 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 10,638 | 10,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOURGEON CAPITAL MANAGEMENT LLC | 0 | 10,400 | +10,400 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 10,279 | +10,279 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 6,977 | 9,761 | +2,784 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 11,974 | 9,458 | -2,516 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,455 | 8,455 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 5,615 | 5,615 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,184 | 5,184 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 7,231 | 4,885 | -2,346 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 4,567 | 4,567 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 3,420 | 4,420 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 4,166 | 4,166 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 2,935 | 2,935 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,330 | 2,614 | -716 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 25,736 | 2,115 | -23,621 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 1,771 | 1,462 | -309 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,826 | 1,336 | -490 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 808 | 808 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Red Tortoise LLC | 801 | 801 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Physician Wealth Advisors, Inc. | 667 | 667 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Optiver Holding B.V. | 606 | 606 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 0 | 192 | +192 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |