| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Velan Capital Investment Management LP | 0 | 1,471,904 | +1,471,904 | 0.00 | 22.76 | +22.76 | buy |
| Soleus Capital Management, L.P. | 0 | 1,187,096 | +1,187,096 | 0.00 | 3.06 | +3.06 | buy |
| Carlyle Group Inc. | 0 | 1,066,189 | +1,066,189 | 0.00 | 1.97 | +1.97 | buy |
| Qiming U.S. Ventures Management, LLC | 0 | 928,964 | +928,964 | 0.00 | 30.41 | +30.41 | buy |
| Avidity Partners Management LP | 0 | 760,000 | +760,000 | 0.00 | 0.79 | +0.79 | buy |
| FRANKLIN RESOURCES INC | 0 | 722,074 | +722,074 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 0 | 612,745 | +612,745 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 0 | 525,000 | +525,000 | 0.00 | 2.38 | +2.38 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 505,242 | +505,242 | 0.00 | 2.40 | +2.40 | buy |
| Octagon Capital Advisors LP | 0 | 500,811 | +500,811 | 0.00 | 1.79 | +1.79 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 497,000 | +497,000 | 0.00 | 1.93 | +1.93 | buy |
| Opaleye Management Inc. | 0 | 435,573 | +435,573 | 0.00 | 2.79 | +2.79 | buy |
| GREAT POINT PARTNERS LLC | 0 | 407,550 | +407,550 | 0.00 | 1.86 | +1.86 | buy |
| Rock Springs Capital Management LP | 0 | 404,335 | +404,335 | 0.00 | 0.30 | +0.30 | buy |
| Woodline Partners LP | 0 | 379,246 | +379,246 | 0.00 | 0.10 | +0.10 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 319,787 | +319,787 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 0 | 289,943 | +289,943 | 0.00 | 4.73 | +4.73 | buy |
| MORGAN STANLEY | 0 | 176,417 | +176,417 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 129,211 | +129,211 | 0.00 | 1.01 | +1.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 127,991 | +127,991 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 111,366 | +111,366 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 109,892 | +109,892 | 0.00 | 0.90 | +0.90 | buy |
| Ikarian Capital, LLC | 0 | 105,175 | +105,175 | 0.00 | 0.84 | +0.84 | buy |
| Russell Investments Group, Ltd. | 0 | 79,811 | +79,811 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 69,100 | +69,100 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 52,826 | +52,826 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 43,945 | +43,945 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 41,894 | +41,894 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 39,999 | +39,999 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 35,000 | +35,000 | 0.00 | 0.25 | +0.25 | buy |
| Lion Point Capital, LP | 0 | 32,000 | +32,000 | 0.00 | 1.80 | +1.80 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 23,324 | +23,324 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 23,271 | +23,271 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 22,697 | +22,697 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 21,525 | +21,525 | 0.00 | 0.10 | +0.10 | buy |
| Concurrent Investment Advisors, LLC | 0 | 20,409 | +20,409 | 0.00 | 0.02 | +0.02 | buy |
| Man Group plc | 0 | 20,357 | +20,357 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 16,210 | +16,210 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 13,449 | +13,449 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 11,397 | +11,397 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 11,172 | +11,172 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 10,410 | +10,410 | 0.00 | 0.02 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 0 | 10,250 | +10,250 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 8,417 | +8,417 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 8,378 | +8,378 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 8,084 | +8,084 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 8,002 | +8,002 | 0.00 | 0.06 | +0.06 | buy |
| Atom Investors LP | 0 | 7,373 | +7,373 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 0 | 7,363 | +7,363 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 3,758 | +3,758 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 2,406 | +2,406 | 0.00 | 0.02 | +0.02 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 744 | +744 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 697 | +697 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| TENOR CAPITAL MANAGEMENT Co., L.P. | 250,000 | 250,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Trading LLC | 14,095 | 14,095 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 26 | 0 | -26 | 0.00 | 0.00 | 0.00 | sell |
| Tower Research Capital LLC (TRC) | 11,144 | 0 | -11,144 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 11,500 | 0 | -11,500 | 0.00 | 0.00 | -0.00 | sell |
| GRIES FINANCIAL LLC | 23,845 | 0 | -23,845 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 36,899 | 0 | -36,899 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 43,593 | 0 | -43,593 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 54,168 | 0 | -54,168 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 54,500 | 0 | -54,500 | 0.00 | 0.00 | -0.00 | sell |
| Summit Trail Advisors, LLC | 65,000 | 0 | -65,000 | 0.00 | 0.00 | -0.00 | sell |
| ZAZOVE ASSOCIATES LLC | 65,456 | 0 | -65,456 | 0.00 | 0.00 | -0.00 | sell |
| CSS LLC/IL | 81,957 | 0 | -81,957 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 695,014 | 596,014 | -99,000 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 129,883 | 0 | -129,883 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 154,909 | 0 | -154,909 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 191,155 | 0 | -191,155 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 229,994 | 0 | -229,994 | 0.00 | 0.00 | -0.00 | sell |
| Monaco Asset Management SAM | 249,563 | 0 | -249,563 | 0.08 | 0.00 | -0.08 | sell |
| BANK OF MONTREAL /CAN/ | 348,300 | 0 | -348,300 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 514,324 | 0 | -514,324 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 590,510 | 0 | -590,510 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 713,063 | 0 | -713,063 | 1.04 | 0.00 | -1.04 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 789,331 | 0 | -789,331 | 0.06 | 0.00 | -0.06 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 904,477 | 0 | -904,477 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 1,386,215 | 0 | -1,386,215 | 0.42 | 0.00 | -0.42 | sell |
| MORGAN STANLEY | 1,699,550 | 0 | -1,699,550 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 1,732,993 | 0 | -1,732,993 | 0.01 | 0.00 | -0.01 | sell |
| Nantahala Capital Management, LLC | 2,228,265 | 0 | -2,228,265 | 0.18 | 0.00 | -0.18 | sell |
| BANK OF AMERICA CORP /DE/ | 3,180,059 | 0 | -3,180,059 | 0.00 | 0.00 | -0.00 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,540,000 | 0 | -3,540,000 | 0.53 | 0.00 | -0.53 | sell |
| Ally Bridge Group (NY) LLC | 3,659,255 | 0 | -3,659,255 | 17.20 | 0.00 | -17.20 | sell |
| Opaleye Management Inc. | 3,985,340 | 0 | -3,985,340 | 0.84 | 0.00 | -0.84 | sell |
| VANGUARD GROUP INC | 4,092,958 | 0 | -4,092,958 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 4,468,114 | 0 | -4,468,114 | 0.56 | 0.00 | -0.56 | sell |
| Qiming U.S. Ventures Management, LLC | 8,519,648 | 0 | -8,519,648 | 6.16 | 0.00 | -6.16 | sell |
| Carlyle Group Inc. | 8,761,891 | 0 | -8,761,891 | 0.32 | 0.00 | -0.32 | sell |
| Soleus Capital Management, L.P. | 9,870,980 | 0 | -9,870,980 | 0.86 | 0.00 | -0.86 | sell |
| Velan Capital Investment Management LP | 11,219,036 | 0 | -11,219,036 | 6.06 | 0.00 | -6.06 | sell |