| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 0 | 483,300 | +483,300 | 0.00 | 0.26 | +0.26 | buy |
| Integral Health Asset Management, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.78 | +0.78 | buy |
| MORGAN STANLEY | 309,419 | 565,722 | +256,303 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 218,614 | 399,466 | +180,852 | 2.96 | 4.02 | +1.07 | buy |
| CITADEL ADVISORS LLC | 0 | 141,564 | +141,564 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 413,940 | 495,104 | +81,164 | 0.09 | 0.08 | -0.01 | buy |
| NORTHERN TRUST CORP | 29,299 | 106,940 | +77,641 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 141,487 | 211,526 | +70,039 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,276,190 | 1,343,665 | +67,475 | 2.55 | 2.10 | -0.45 | buy |
| MARSHALL WACE, LLP | 0 | 66,325 | +66,325 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 525,000 | 584,642 | +59,642 | 2.49 | 2.11 | -0.38 | buy |
| Rock Springs Capital Management LP | 404,335 | 459,088 | +54,753 | 0.28 | 0.28 | +0.00 | buy |
| FMR LLC | 0 | 38,361 | +38,361 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 36,925 | +36,925 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 25,353 | +25,353 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 23,759 | +23,759 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 191,319 | 214,883 | +23,564 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 20,520 | +20,520 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 36,201 | 55,765 | +19,564 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 16,391 | +16,391 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 15,816 | +15,816 | 0.00 | 0.05 | +0.05 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 14,743 | +14,743 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,838 | 16,146 | +12,308 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 11,219 | +11,219 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 6,212 | +6,212 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,463 | 8,165 | +5,702 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 690,059 | 694,425 | +4,366 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 3,001 | 6,874 | +3,873 | 0.00 | 0.00 | +0.00 | buy |
| WOLFF WIESE MAGANA LLC | 0 | 3,146 | +3,146 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 14,204 | 16,806 | +2,602 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 814 | 2,512 | +1,698 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 930 | +930 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 695 | +695 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 325,324 | 325,881 | +557 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 512 | +512 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 15 | +15 | 0.00 | 0.00 | 0.00 | buy |
| SIGNATUREFD, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 497,000 | 497,000 | 0 | 1.74 | 1.37 | -0.37 | hold |
| ZAZOVE ASSOCIATES LLC | 65,456 | 65,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,109 | 1,109 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 820 | 820 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TENOR CAPITAL MANAGEMENT Co., L.P. | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Trading LLC | 14,095 | 14,095 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Carlyle Group Inc. | 1,066,189 | 1,066,189 | 0 | 2.30 | 2.08 | -0.21 | hold |
| Lion Point Capital, LP | 32,000 | 32,000 | 0 | 2.27 | 2.41 | +0.14 | hold |
| Walleye Capital LLC | 596,014 | 596,014 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Polar Capital Holdings Plc | 581,538 | 581,538 | 0 | 0.08 | 0.05 | -0.03 | hold |
| Qiming U.S. Ventures Management, LLC | 928,964 | 928,964 | 0 | 40.07 | 34.02 | -6.05 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,600 | 4,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 2,100 | 2,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,407 | 32,407 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 392 | 392 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 48 | 17 | -31 | 0.00 | 0.00 | 0.00 | sell |
| Corebridge Financial, Inc. | 6,090 | 6,053 | -37 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 1,255 | 1,213 | -42 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 100 | 1 | -99 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 13,231 | 13,109 | -122 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 3,725 | 3,587 | -138 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 1,000 | 0 | -1,000 | 0.01 | 0.00 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 259,754 | 257,416 | -2,338 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 5,821 | 1,354 | -4,467 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 47,328 | 42,206 | -5,122 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 16,357 | 10,000 | -6,357 | 0.10 | 0.06 | -0.05 | sell |
| Bank of New York Mellon Corp | 32,579 | 24,030 | -8,549 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 10,719 | 0 | -10,719 | 0.04 | 0.00 | -0.04 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 23,324 | 12,236 | -11,088 | 0.02 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 19,121 | 0 | -19,121 | 0.00 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 21,525 | 0 | -21,525 | 0.08 | 0.00 | -0.08 | sell |
| MILLENNIUM MANAGEMENT LLC | 22,990 | 0 | -22,990 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 39,828 | 5,274 | -34,554 | 0.02 | 0.00 | -0.02 | sell |
| Velan Capital Investment Management LP | 1,471,904 | 1,433,828 | -38,076 | 18.65 | 29.28 | +10.63 | sell |
| Opaleye Management Inc. | 392,000 | 353,500 | -38,500 | 2.03 | 1.11 | -0.92 | sell |
| Ikarian Capital, LLC | 105,175 | 55,175 | -50,000 | 0.74 | 0.32 | -0.42 | sell |
| Walleye Capital LLC | 52,669 | 0 | -52,669 | 0.01 | 0.00 | -0.01 | sell |
| CANTOR FITZGERALD, L. P. | 61,603 | 0 | -61,603 | 0.28 | 0.00 | -0.28 | sell |
| DEUTSCHE BANK AG\ | 194,435 | 131,259 | -63,176 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 402,015 | 322,380 | -79,635 | 1.75 | 1.83 | +0.08 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 109,892 | 0 | -109,892 | 0.62 | 0.00 | -0.62 | sell |
| FRANKLIN RESOURCES INC | 698,536 | 579,636 | -118,900 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 143,775 | 0 | -143,775 | 0.96 | 0.00 | -0.96 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 454,227 | 189,270 | -264,957 | 1.68 | 0.58 | -1.10 | sell |
| Octagon Capital Advisors LP | 287,500 | 0 | -287,500 | 1.08 | 0.00 | -1.08 | sell |
| Avidity Partners Management LP | 782,000 | 0 | -782,000 | 0.75 | 0.00 | -0.75 | sell |