| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 8,300,980 | 9,870,980 | +1,570,000 | 0.59 | 0.86 | +0.28 | buy |
| Ally Bridge Group (NY) LLC | 3,144,164 | 3,659,255 | +515,091 | 2.58 | 17.20 | +14.62 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,040,000 | 3,540,000 | +500,000 | 0.39 | 0.53 | +0.14 | buy |
| Saturn V Capital Management LP | 1,387,015 | 1,386,215 | -800 | 0.41 | 0.42 | +0.01 | sell |
| Nantahala Capital Management, LLC | 2,402,904 | 2,228,265 | -174,639 | 0.14 | 0.11 | -0.04 | sell |
| Woodline Partners LP | 3,000,000 | 1,732,993 | -1,267,007 | 0.02 | 0.01 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 5,687,134 | 713,063 | -4,974,071 | 0.73 | 0.91 | +0.18 | sell |