| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 38,361 | 388,523 | +350,162 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 350,000 | 650,000 | +300,000 | 0.78 | 1.23 | +0.45 | buy |
| CITADEL ADVISORS LLC | 141,564 | 423,610 | +282,046 | 0.00 | 0.01 | +0.01 | buy |
| BRAIDWELL LP | 483,300 | 714,658 | +231,358 | 0.26 | 0.45 | +0.20 | buy |
| UBS Group AG | 0 | 164,315 | +164,315 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 55,765 | 210,305 | +154,540 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,343,665 | 1,494,420 | +150,755 | 2.10 | 2.42 | +0.32 | buy |
| STEMPOINT CAPITAL LP | 0 | 135,244 | +135,244 | 0.00 | 0.73 | +0.73 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 82,165 | +82,165 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 59,034 | +59,034 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 353,500 | 400,000 | +46,500 | 1.11 | 1.50 | +0.39 | buy |
| DEUTSCHE BANK AG\ | 131,259 | 170,695 | +39,436 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 565,722 | 604,792 | +39,070 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 211,526 | 247,272 | +35,746 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 31,250 | +31,250 | 0.00 | 0.01 | +0.01 | buy |
| Palo Alto Investors LP | 0 | 30,651 | +30,651 | 0.00 | 0.10 | +0.10 | buy |
| Sowell Financial Services LLC | 0 | 28,043 | +28,043 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Trading LLC | 14,095 | 35,138 | +21,043 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 20,000 | +20,000 | 0.00 | 0.03 | +0.03 | buy |
| Propel Bio Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.42 | +0.42 | buy |
| STATE STREET CORP | 214,883 | 230,306 | +15,423 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 694,425 | 709,484 | +15,059 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 13,724 | +13,724 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 66,325 | 77,722 | +11,397 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 10,852 | +10,852 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 10,431 | +10,431 | 0.00 | 0.09 | +0.09 | buy |
| BlackRock, Inc. | 800,028 | 808,086 | +8,058 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 459,088 | 463,088 | +4,000 | 0.28 | 0.38 | +0.10 | buy |
| WELLS FARGO & COMPANY/MN | 3,587 | 7,415 | +3,828 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 23,759 | 27,069 | +3,310 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,520 | 22,814 | +2,294 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 16,146 | 18,334 | +2,188 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,109 | 14,761 | +1,652 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 12,236 | 13,853 | +1,617 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 16,806 | 17,979 | +1,173 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 24,030 | 25,078 | +1,048 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 1,032 | +1,032 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,165 | 9,060 | +895 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 695 | 1,555 | +860 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 36,925 | 37,705 | +780 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,512 | 2,888 | +376 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,212 | 6,516 | +304 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 257,416 | 257,687 | +271 | 0.00 | 0.00 | +0.00 | buy |
| Greenline Partners, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5 | 53 | +48 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 15 | 20 | +5 | 0.00 | 0.00 | 0.00 | buy |
| ZAZOVE ASSOCIATES LLC | 65,456 | 65,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,109 | 1,109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 820 | 820 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 17 | 17 | 0 | 0.00 | 0.00 | 0.00 | hold |
| GREAT POINT PARTNERS LLC | 322,380 | 322,380 | 0 | 1.83 | 3.25 | +1.42 | hold |
| Sterling Capital Management LLC | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TENOR CAPITAL MANAGEMENT Co., L.P. | 250,000 | 250,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Carlyle Group Inc. | 1,066,189 | 1,066,189 | 0 | 2.08 | 0.55 | -1.54 | hold |
| MetLife Investment Management, LLC | 6,874 | 6,874 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lion Point Capital, LP | 32,000 | 32,000 | 0 | 2.41 | 3.58 | +1.17 | hold |
| Samsara BioCapital, LLC | 584,642 | 584,642 | 0 | 2.11 | 1.72 | -0.40 | hold |
| Velan Capital Investment Management LP | 1,433,828 | 1,433,828 | 0 | 29.28 | 26.45 | -2.82 | hold |
| Qiming U.S. Ventures Management, LLC | 928,964 | 928,964 | 0 | 34.02 | 38.83 | +4.81 | hold |
| FRANKLIN RESOURCES INC | 579,636 | 579,636 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,213 | 1,213 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,600 | 4,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 392 | 392 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 512 | 511 | -1 | 0.00 | 0.00 | +0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 55,175 | 55,107 | -68 | 0.32 | 0.34 | +0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 32,407 | 32,337 | -70 | 0.00 | 0.00 | +0.00 | sell |
| WOLFF WIESE MAGANA LLC | 3,146 | 2,887 | -259 | 0.04 | 0.04 | +0.00 | sell |
| Corebridge Financial, Inc. | 6,053 | 5,628 | -425 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 930 | 0 | -930 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,354 | 0 | -1,354 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 2,100 | 0 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 106,940 | 104,367 | -2,573 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 5,274 | 0 | -5,274 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 42,206 | 36,794 | -5,412 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 10,000 | 0 | -10,000 | 0.06 | 0.00 | -0.06 | sell |
| Verition Fund Management LLC | 25,353 | 15,050 | -10,303 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 11,219 | 0 | -11,219 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 16,391 | 5,165 | -11,226 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 14,743 | 0 | -14,743 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 15,816 | 0 | -15,816 | 0.05 | 0.00 | -0.05 | sell |
| Walleye Capital LLC | 596,014 | 573,640 | -22,374 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 325,881 | 287,204 | -38,677 | 0.00 | 0.00 | +0.00 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 497,000 | 447,000 | -50,000 | 1.37 | 1.63 | +0.26 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 189,270 | 135,720 | -53,550 | 0.58 | 0.54 | -0.05 | sell |
| Woodline Partners LP | 495,104 | 245,676 | -249,428 | 0.08 | 0.04 | -0.04 | sell |
| Ally Bridge Group (NY) LLC | 399,466 | 122,424 | -277,042 | 4.02 | 2.24 | -1.78 | sell |
| Polar Capital Holdings Plc | 581,538 | 0 | -581,538 | 0.05 | 0.00 | -0.05 | sell |