| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Integral Health Asset Management, LLC | 350,000 | 650,000 | +300,000 | 0.78 | 1.23 | +0.45 | buy |
| BRAIDWELL LP | 483,300 | 714,658 | +231,358 | 0.26 | 0.45 | +0.20 | buy |
| Soleus Capital Management, L.P. | 1,343,665 | 1,494,420 | +150,755 | 2.10 | 2.42 | +0.32 | buy |
| Opaleye Management Inc. | 353,500 | 400,000 | +46,500 | 1.11 | 1.50 | +0.39 | buy |
| Rock Springs Capital Management LP | 459,088 | 463,088 | +4,000 | 0.28 | 0.38 | +0.10 | buy |
| Ikarian Capital, LLC | 55,175 | 55,107 | -68 | 0.32 | 0.34 | +0.01 | sell |
| WOLFF WIESE MAGANA LLC | 3,146 | 2,887 | -259 | 0.04 | 0.04 | +0.00 | sell |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 497,000 | 447,000 | -50,000 | 1.37 | 1.63 | +0.26 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 189,270 | 135,720 | -53,550 | 0.57 | 0.52 | -0.04 | sell |
| Woodline Partners LP | 495,104 | 245,676 | -249,428 | 0.08 | 0.04 | -0.04 | sell |
| Ally Bridge Group (NY) LLC | 399,466 | 122,424 | -277,042 | 4.02 | 2.24 | -1.78 | sell |