| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 61,633 | 317,324 | +255,691 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 53,253 | 212,244 | +158,991 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 69,000 | +69,000 | 0.00 | 1.23 | +1.23 | buy |
| DIMENSIONAL FUND ADVISORS LP | 57,942 | 77,349 | +19,407 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 18,700 | +18,700 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 151,190 | 168,098 | +16,908 | 0.00 | 0.00 | +0.00 | buy |
| BML Capital Management, LLC | 400,000 | 416,720 | +16,720 | 4.74 | 5.85 | +1.11 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 13,864 | +13,864 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 13,490 | +13,490 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,827 | 14,826 | +11,999 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 192,433 | 203,933 | +11,500 | 0.16 | 0.20 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 126,927 | 132,431 | +5,504 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 5,397 | +5,397 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 14,795 | 17,595 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 41,735 | 43,215 | +1,480 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,076 | 3,232 | +156 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 0 | 79 | +79 | 0.00 | 0.00 | +0.00 | buy |
| EQ WEALTH ADVISORS, LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 116,785 | 116,785 | 0 | 0.05 | 0.05 | +0.00 | hold |
| RHUMBLINE ADVISERS | 114 | 114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 11,165 | 11,165 | 0 | 0.03 | 0.04 | +0.00 | hold |
| CPMG Inc | 410,922 | 410,922 | 0 | 25.82 | 43.55 | +17.73 | hold |
| VR Adviser, LLC | 33,177 | 33,177 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Vivo Capital, LLC | 585,485 | 585,485 | 0 | 1.25 | 1.35 | +0.09 | hold |
| Curative Ventures V LLC | 1,899,004 | 1,899,004 | 0 | 100.00 | 100.00 | 0.00 | hold |
| Frazier Financial Advisors, LLC | 15 | 15 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRED ALGER MANAGEMENT, LLC | 31,314 | 31,314 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOKF, NA | 454 | 454 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,410 | 1,392 | -18 | 0.00 | 0.00 | +0.00 | sell |
| R Squared Ltd | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| Militia Capital Partners, LP | 416 | 0 | -416 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 23,698 | 22,298 | -1,400 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 59,767 | 57,971 | -1,796 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,843 | 2 | -2,841 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 31,708 | 24,328 | -7,380 | 0.12 | 0.08 | -0.04 | sell |
| Assenagon Asset Management S.A. | 62,558 | 53,097 | -9,461 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 50,000 | 40,000 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 12,533 | 0 | -12,533 | 0.02 | 0.00 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 133,755 | 104,943 | -28,812 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 34,557 | 0 | -34,557 | 0.06 | 0.00 | -0.06 | sell |
| UBS Group AG | 91,086 | 0 | -91,086 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 148,017 | 0 | -148,017 | 2.48 | 0.00 | -2.48 | sell |
| Boxer Capital Management, LLC | 355,500 | 80,125 | -275,375 | 0.58 | 0.42 | -0.16 | sell |