| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Curative Ventures V LLC | 1,899,004 | 1,899,004 | 0 | 100.00 | 100.00 | 0.00 | hold |
| BML Capital Management, LLC | 416,720 | 534,899 | +118,179 | 5.85 | 8.54 | +2.68 | buy |
| CPMG Inc | 410,922 | 410,922 | 0 | 43.55 | 38.82 | -4.73 | hold |
| Vivo Capital, LLC | 585,485 | 292,743 | -292,742 | 1.35 | 0.62 | -0.72 | sell |
| Siren, L.L.C. | 203,933 | 203,933 | 0 | 0.20 | 0.22 | +0.02 | hold |
| VANGUARD GROUP INC | 168,098 | 168,098 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GOLDMAN SACHS GROUP INC | 132,431 | 163,261 | +30,830 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 212,244 | 108,097 | -104,147 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 0 | 96,308 | +96,308 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 317,324 | 88,796 | -228,528 | 0.01 | 0.00 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 0 | 86,220 | +86,220 | 0.00 | 1.19 | +1.19 | buy |
| DIMENSIONAL FUND ADVISORS LP | 77,349 | 82,822 | +5,473 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 80,125 | 70,700 | -9,425 | 0.42 | 0.74 | +0.32 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 104,943 | 70,655 | -34,288 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 0 | 64,413 | +64,413 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 53,097 | 57,497 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 57,971 | 50,733 | -7,238 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 43,215 | 43,094 | -121 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 17,595 | 17,595 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Trexquant Investment LP | 0 | 17,369 | +17,369 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 16,200 | +16,200 | 0.00 | 0.28 | +0.28 | buy |
| Americana Partners, LLC | 0 | 12,926 | +12,926 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 14,826 | 10,400 | -4,426 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 5,397 | 7,987 | +2,590 | 0.01 | 0.02 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,232 | 2,727 | -505 | 0.00 | 0.00 | +0.00 | sell |
| BOKF, NA | 454 | 454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,392 | 215 | -1,177 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 114 | 114 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EQ WEALTH ADVISORS, LLC | 40 | 40 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Financial Advisors, LLC | 15 | 15 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 2 | 1 | -1 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 18,700 | 0 | -18,700 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 116,785 | 0 | -116,785 | 0.05 | 0.00 | -0.05 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 11,165 | 0 | -11,165 | 0.04 | 0.00 | -0.04 | sell |
| MARSHALL WACE, LLP | 22,298 | 0 | -22,298 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 33,177 | 0 | -33,177 | 0.05 | 0.00 | -0.05 | sell |
| Schonfeld Strategic Advisors LLC | 13,864 | 0 | -13,864 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 69,000 | 0 | -69,000 | 1.23 | 0.00 | -1.23 | sell |
| ADAR1 Capital Management, LLC | 24,328 | 0 | -24,328 | 0.08 | 0.00 | -0.08 | sell |
| FMR LLC | 79 | 0 | -79 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 31,314 | 0 | -31,314 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 13,490 | 0 | -13,490 | 0.00 | 0.00 | -0.00 | sell |