| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 0 | 345,545 | +345,545 | 0.00 | 0.50 | +0.50 | buy |
| Commodore Capital LP | 0 | 150,929 | +150,929 | 0.00 | 0.63 | +0.63 | buy |
| Invesco Ltd. | 0 | 145,118 | +145,118 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 107,545 | +107,545 | 0.00 | 6.47 | +6.47 | buy |
| Point72 Asset Management, L.P. | 0 | 95,450 | +95,450 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 0 | 33,700 | +33,700 | 0.00 | 0.04 | +0.04 | buy |
| VR Adviser, LLC | 0 | 33,177 | +33,177 | 0.00 | 0.12 | +0.12 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 31,332 | +31,332 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 0 | 29,100 | +29,100 | 0.00 | 0.10 | +0.10 | buy |
| ADAR1 Capital Management, LLC | 0 | 23,707 | +23,707 | 0.00 | 0.27 | +0.27 | buy |
| VANGUARD GROUP INC | 129,278 | 151,190 | +21,912 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 17,222 | +17,222 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 11,165 | +11,165 | 0.00 | 0.10 | +0.10 | buy |
| HRT FINANCIAL LP | 0 | 10,902 | +10,902 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 10,517 | +10,517 | 0.00 | 0.16 | +0.16 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 9,953 | +9,953 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 7,103 | +7,103 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 115 | 5,730 | +5,615 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 5,374 | +5,374 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Pointe Advisors, LLC | 0 | 4,849 | +4,849 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 3,800 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 36,393 | 40,131 | +3,738 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 3,605 | +3,605 | 0.00 | 0.02 | +0.02 | buy |
| Virtu Financial LLC | 0 | 3,335 | +3,335 | 0.00 | 0.01 | +0.01 | buy |
| FORA Capital, LLC | 0 | 3,085 | +3,085 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 2,981 | +2,981 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 2,332 | +2,332 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 963 | +963 | 0.00 | 0.00 | +0.00 | buy |
| BOKF, NA | 0 | 354 | +354 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 114 | 114 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CPMG Inc | 410,922 | 410,922 | 0 | 6.32 | 24.17 | +17.85 | hold |
| Vivo Capital, LLC | 624,339 | 624,339 | 0 | 0.59 | 3.48 | +2.88 | hold |
| Curative Ventures V LLC | 1,899,004 | 1,899,004 | 0 | 100.00 | 100.00 | 0.00 | hold |
| Frazier Financial Advisors, LLC | 15 | 15 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 12,182 | 12,182 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 106 | 65 | -41 | 0.00 | 0.00 | +0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 500 | 125 | -375 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 479 | 60 | -419 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 625 | 0 | -625 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 10,244 | 0 | -10,244 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 116,255 | 96,855 | -19,400 | 0.00 | 0.01 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 23,790 | 0 | -23,790 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 28,089 | 0 | -28,089 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 31,631 | 0 | -31,631 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 60,626 | 23,426 | -37,200 | 0.00 | 0.00 | +0.00 | sell |
| BML Capital Management, LLC | 391,103 | 335,000 | -56,103 | 2.95 | 13.27 | +10.32 | sell |
| Nantahala Capital Management, LLC | 127,292 | 20,276 | -107,016 | 0.13 | 0.11 | -0.02 | sell |
| Cable Car Capital, LP | 258,097 | 0 | -258,097 | 2.80 | 0.00 | -2.80 | sell |