| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Curative Ventures V LLC | 1,899,004 | 1,899,004 | 0 | 100.00 | 100.00 | 0.00 | hold |
| BML Capital Management, LLC | 534,899 | 645,600 | +110,701 | 8.54 | 10.61 | +2.07 | buy |
| CPMG Inc | 410,922 | 410,922 | 0 | 38.82 | 35.99 | -2.83 | hold |
| Vivo Capital, LLC | 292,743 | 292,743 | 0 | 0.62 | 0.42 | -0.20 | hold |
| Siren, L.L.C. | 203,933 | 203,933 | 0 | 0.22 | 0.14 | -0.08 | hold |
| MILLENNIUM MANAGEMENT LLC | 108,097 | 196,742 | +88,645 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 168,098 | 167,810 | -288 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 86,220 | 161,380 | +75,160 | 1.19 | 1.78 | +0.59 | buy |
| MORGAN STANLEY | 96,308 | 102,938 | +6,630 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 82,822 | 80,816 | -2,006 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 50,733 | 61,682 | +10,949 | 0.00 | 0.00 | -0.00 | buy |
| Boxer Capital Management, LLC | 70,700 | 60,700 | -10,000 | 0.74 | 0.35 | -0.40 | sell |
| MACQUARIE GROUP LTD | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 0 | 44,878 | +44,878 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 43,094 | 42,339 | -755 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 0 | 33,687 | +33,687 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 20,802 | +20,802 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 17,595 | 17,595 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 64,413 | 15,684 | -48,729 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 7,987 | 14,747 | +6,760 | 0.02 | 0.02 | +0.00 | buy |
| Americana Partners, LLC | 12,926 | 10,676 | -2,250 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 10,400 | 6,150 | -4,250 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 215 | 3,134 | +2,919 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,727 | 3,104 | +377 | 0.00 | 0.00 | -0.00 | buy |
| BOKF, NA | 454 | 454 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 114 | 114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Financial Advisors, LLC | 15 | 15 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 70,655 | 0 | -70,655 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 88,796 | 0 | -88,796 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 57,497 | 0 | -57,497 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 17,369 | 0 | -17,369 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 16,200 | 0 | -16,200 | 0.28 | 0.00 | -0.28 | sell |
| EQ WEALTH ADVISORS, LLC | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 3,000 | 0 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 163,261 | 0 | -163,261 | 0.00 | 0.00 | -0.00 | sell |