| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 624,340 | +624,340 | 0.00 | 0.39 | +0.39 | buy |
| CPMG Inc | 0 | 410,923 | +410,923 | 0.00 | 1.36 | +1.36 | buy |
| VANGUARD GROUP INC | 0 | 130,102 | +130,102 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 127,292 | +127,292 | 0.00 | 0.10 | +0.10 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 113,614 | +113,614 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 60,626 | +60,626 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 50,800 | +50,800 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 49,737 | +49,737 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 36,789 | +36,789 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 31,426 | +31,426 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 28,298 | +28,298 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 27,836 | +27,836 | 0.00 | 0.00 | +0.00 | buy |
| Anson Funds Management LP | 0 | 17,344 | +17,344 | 0.00 | 0.03 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 14,014 | +14,014 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 12,582 | +12,582 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 114 | +114 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 18 | +18 | 0.00 | 0.00 | 0.00 | buy |
| CITIGROUP INC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Covestor Ltd | 88 | 0 | -88 | 0.00 | 0.00 | 0.00 | sell |
| Daiwa Securities Group Inc. | 376 | 0 | -376 | 0.00 | 0.00 | 0.00 | sell |
| CITIGROUP INC | 1,741 | 0 | -1,741 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 2,290 | 0 | -2,290 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,346 | 0 | -3,346 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 6,197 | 0 | -6,197 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 10,545 | 0 | -10,545 | 0.00 | 0.00 | -0.00 | sell |
| FIDELIS CAPITAL PARTNERS, LLC | 11,288 | 0 | -11,288 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 12,413 | 0 | -12,413 | 0.00 | 0.00 | -0.00 | sell |
| COMMERCE BANK | 13,463 | 0 | -13,463 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 14,924 | 0 | -14,924 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 16,500 | 0 | -16,500 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 25,998 | 0 | -25,998 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 26,055 | 0 | -26,055 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 29,857 | 0 | -29,857 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 31,721 | 0 | -31,721 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 38,245 | 0 | -38,245 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 39,739 | 0 | -39,739 | 0.00 | 0.00 | -0.00 | sell |
| HCR Wealth Advisors | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 41,696 | 0 | -41,696 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 50,493 | 0 | -50,493 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 59,500 | 0 | -59,500 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 59,627 | 0 | -59,627 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 63,864 | 0 | -63,864 | 0.00 | 0.00 | -0.00 | sell |
| Beacon Pointe Advisors, LLC | 96,999 | 0 | -96,999 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 98,080 | 0 | -98,080 | 0.00 | 0.00 | -0.00 | sell |
| Long Focus Capital Management, LLC | 100,000 | 0 | -100,000 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 106,295 | 0 | -106,295 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 120,000 | 0 | -120,000 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 251,650 | 0 | -251,650 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 282,938 | 0 | -282,938 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 353,036 | 0 | -353,036 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 504,268 | 0 | -504,268 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 662,038 | 0 | -662,038 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 742,287 | 0 | -742,287 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 867,279 | 0 | -867,279 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 1,000,000 | 0 | -1,000,000 | 0.05 | 0.00 | -0.05 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,045,426 | 0 | -1,045,426 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,063,249 | 0 | -1,063,249 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 1,212,524 | 0 | -1,212,524 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,782,328 | 0 | -1,782,328 | 0.00 | 0.00 | -0.00 | sell |
| Western Standard LLC | 1,796,987 | 0 | -1,796,987 | 0.69 | 0.00 | -0.69 | sell |
| VANGUARD GROUP INC | 2,672,610 | 0 | -2,672,610 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 4,704,395 | 0 | -4,704,395 | 0.01 | 0.00 | -0.01 | sell |
| CPMG Inc | 8,218,467 | 0 | -8,218,467 | 1.92 | 0.00 | -1.92 | sell |
| Vivo Capital, LLC | 12,486,787 | 0 | -12,486,787 | 0.59 | 0.00 | -0.59 | sell |
| Curative Ventures V LLC | 37,980,073 | 1,899,004 | -36,081,069 | 100.00 | 100.00 | 0.00 | sell |